Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression LS Qi, MH Larson, LA Gilbert, JA Doudna, JS Weissman, AP Arkin, ... Cell 152 (5), 1173-1183, 2013 | 5675 | 2013 |
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes LA Gilbert, MH Larson, L Morsut, Z Liu, GA Brar, SE Torres, ... Cell 154 (2), 442-451, 2013 | 4244 | 2013 |
Genome-scale CRISPR-mediated control of gene repression and activation LA Gilbert, MA Horlbeck, B Adamson, JE Villalta, Y Chen, EH Whitehead, ... Cell 159 (3), 647-661, 2014 | 2776 | 2014 |
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system B Chen, LA Gilbert, BA Cimini, J Schnitzbauer, W Zhang, GW Li, J Park, ... Cell 155 (7), 1479-1491, 2013 | 2226 | 2013 |
A protein-tagging system for signal amplification in gene expression and fluorescence imaging ME Tanenbaum, LA Gilbert, LS Qi, JS Weissman, RD Vale Cell 159 (3), 635-646, 2014 | 1594 | 2014 |
CRISPR interference (CRISPRi) for sequence-specific control of gene expression MH Larson, LA Gilbert, X Wang, WA Lim, JS Weissman, LS Qi Nature protocols 8 (11), 2180-2196, 2013 | 1391 | 2013 |
CRISPR/Cas9 in genome editing and beyond H Wang, M La Russa, LS Qi Annual review of biochemistry 85, 227-264, 2016 | 1267 | 2016 |
Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds JG Zalatan, ME Lee, R Almeida, LA Gilbert, EH Whitehead, M La Russa, ... Cell 160 (1), 339-350, 2015 | 1079 | 2015 |
Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation AA Dominguez, WA Lim, LS Qi Nature reviews Molecular cell biology 17 (1), 5-15, 2016 | 1025 | 2016 |
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription JA Doudna, M Jinek, E Charpentier, K Chylinski US Patent 10,266,850, 2019 | 946 | 2019 |
A comprehensive, CRISPR-based functional analysis of essential genes in bacteria JM Peters, A Colavin, H Shi, TL Czarny, MH Larson, S Wong, JS Hawkins, ... Cell 165 (6), 1493-1506, 2016 | 680 | 2016 |
CRISPR interference efficiently induces specific and reversible gene silencing in human iPSCs MA Mandegar, N Huebsch, EB Frolov, E Shin, A Truong, MP Olvera, ... Cell stem cell 18 (4), 541-553, 2016 | 529 | 2016 |
Small molecules enhance CRISPR genome editing in pluripotent stem cells C Yu, Y Liu, T Ma, K Liu, S Xu, Y Zhang, H Liu, M La Russa, M Xie, S Ding, ... Cell stem cell 16 (2), 142-147, 2015 | 492 | 2015 |
Development of CRISPR as an antiviral strategy to combat SARS-CoV-2 and influenza TR Abbott, G Dhamdhere, Y Liu, X Lin, L Goudy, L Zeng, A Chemparathy, ... Cell 181 (4), 865-876. e12, 2020 | 449 | 2020 |
Combinatorial CRISPR–Cas9 screens for de novo mapping of genetic interactions JP Shen, D Zhao, R Sasik, J Luebeck, A Birmingham, ... Nature methods 14 (6), 573-576, 2017 | 365 | 2017 |
Complex transcriptional modulation with orthogonal and inducible dCas9 regulators Y Gao, X Xiong, S Wong, EJ Charles, WA Lim, LS Qi Nature methods 13 (12), 1043-1049, 2016 | 331 | 2016 |
High-content CRISPR screening C Bock, P Datlinger, F Chardon, MA Coelho, MB Dong, KA Lawson, T Lu, ... Nature Reviews Methods Primers 2 (1), 1-23, 2022 | 321 | 2022 |
Versatile RNA-sensing transcriptional regulators for engineering genetic networks JB Lucks, L Qi, VK Mutalik, D Wang, AP Arkin Proceedings of the National Academy of Sciences 108 (21), 8617-8622, 2011 | 286 | 2011 |
The new state of the art: Cas9 for gene activation and repression MF La Russa, LS Qi Molecular and cellular biology 35 (22), 3800-3809, 2015 | 275 | 2015 |
A CRISPR–dCas toolbox for genetic engineering and synthetic biology X Xu, LS Qi Journal of molecular biology 431 (1), 34-47, 2019 | 271 | 2019 |