Cell culture media for recombinant protein expression in Chinese hamster ovary (CHO) cells: History, key components, and optimization strategies FV Ritacco, Y Wu, A Khetan Biotechnology progress 34 (6), 1407-1426, 2018 | 272 | 2018 |
Control of misincorporation of serine for asparagine during antibody production using CHO cells A Khetan, Y Huang, J Dolnikova, NE Pederson, D Wen, ... Biotechnology and bioengineering 107 (1), 116-123, 2010 | 72 | 2010 |
Method of supplementing culture media to prevent undesirable amino acid substitutions A Khetan, YM Huang, J Dolnikova, N Pederson, H Yusuf-Makagiansar, ... US Patent 9,096,879, 2015 | 48 | 2015 |
Precursor and Cofactor as a Check Valve for Cephamycin Biosynthesis in Streptomycesclavuligerus A Khetan, LH Malmberg, YS Kyung, DH Sherman, WS Hu Biotechnology progress 15 (6), 1020-1027, 1999 | 24 | 1999 |
Advancement in bioprocess technology: parallels between microbial natural products and cell culture biologics AA Bandyopadhyay, A Khetan, LH Malmberg, W Zhou, WS Hu Journal of Industrial Microbiology and Biotechnology 44 (4-5), 785-797, 2017 | 20 | 2017 |
Enabling speed to clinic for monoclonal antibody programs using a pool of clones for IND-enabling toxicity studies P Bolisetty, G Tremml, S Xu, A Khetan MAbs 12 (1), 1763727, 2020 | 18 | 2020 |
Gradient elution behavior of proteins in hydrophobic interaction chromatography with U-shaped retention factor curves A Creasy, J Lomino, G Barker, A Khetan, G Carta Journal of Chromatography A 1547, 53-61, 2018 | 18 | 2018 |
Metabolic engineering of cephalosporin biosynthesis in Streptomyces clavuligerus. A Khetan, LH Malmberg, DH Sherman, WS Hu Annals of the New York Academy of Sciences 782, 17-24, 1996 | 18 | 1996 |
Heterogeneous distribution of lysine 6-aminotransferase during cephamycin C biosynthesis in Streptomyces clavuligerus demonstrated using green fluorescent … A Khetan, WS Hu, DH Sherman Microbiology 146 (8), 1869-1880, 2000 | 17 | 2000 |
N-1 perfusion platform development using a capacitance probe for biomanufacturing ESC Rittershaus, MS Rehmann, J Xu, Q He, C Hill, J Swanberg, ... Bioengineering 9 (4), 128, 2022 | 16 | 2022 |
Understanding the effect of high gas entrance velocity on Chinese hamster ovary (CHO) cell culture performance and its implications on bioreactor scale‐up and sparger design G Chaudhary, R Luo, M George, L Tescione, A Khetan, H Lin Biotechnology and Bioengineering 117 (6), 1684-1695, 2020 | 16 | 2020 |
Upstream cell culture process characterization and in-process control strategy development at pandemic speed J Xu, J Ou, KP McHugh, MC Borys, A Khetan MAbs 14 (1), 2060724, 2022 | 14 | 2022 |
Time‐lapsed confocal microscopy reveals temporal and spatial expression of the lysine ɛ‐aminotransferase gene in Streptomyces clavuligerus L Han, A Khetan, WS Hu, DH Sherman Molecular Microbiology 34 (5), 878-886, 1999 | 13 | 1999 |
Applications of small molecules in modulating productivity and product quality of recombinant proteins produced using cell cultures P Xu, S Xu, C He, A Khetan Biotechnology Advances 43, 107577, 2020 | 12 | 2020 |
Process modeling of recombinant adeno-associated virus production in HEK293 cells J Joiner, Z Huang, K McHugh, M Stebbins, K Aron, M Borys, A Khetan Current Opinion in Chemical Engineering 36, 100823, 2022 | 11 | 2022 |
Metabolic engineering of antibiotic biosynthetic pathways A Khetan Manual of industrial microbiology and biotechnology, 717-724, 1999 | 10 | 1999 |
New insights into genetic instability of an industrial CHO cell line by orthogonal omics Y Qian, SW Sowa, KL Aron, P Xu, E Langsdorf, B Warrack, N Aranibar, ... Biochemical Engineering Journal 164, 107799, 2020 | 9 | 2020 |
Suitability of a generic virus safety evaluation for monoclonal antibody investigational new drug applications P Sipple, T Nguyen, K Patel, N Jaffe, Y Chen, A Khetan Biotechnology Progress 35 (5), e2850, 2019 | 9 | 2019 |
Metabolic engineering of antibiotic biosynthesis for process improvement A Khetan, WS Hu Bioprocess technology 24, 177-202, 1997 | 8 | 1997 |
Recent advances in upstream process development for production of recombinant adeno‐associated virus J Ou, Y Tang, J Xu, J Tucci, MC Borys, A Khetan Biotechnology and Bioengineering 121 (1), 53-70, 2024 | 6 | 2024 |