Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity GM Pagnotti, M Styner, G Uzer, VS Patel, LE Wright, KK Ness, TA Guise, ... Nature Reviews Endocrinology 15 (6), 339-355, 2019 | 190 | 2019 |
Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the loading regimen B Sen, Z Xie, N Case, M Styner, CT Rubin, J Rubin Journal of biomechanics 44 (4), 593-599, 2011 | 180 | 2011 |
Cell mechanosensitivity to extremely lowmagnitude signals is enabled by a LINCed nucleus G Uzer, WR Thompson, B Sen, Z Xie, SS Yen, S Miller, G Bas, M Styner, ... Stem cells 33 (6), 2063-2076, 2015 | 161 | 2015 |
mTORC2 regulates mechanically induced cytoskeletal reorganization and lineage selection in marrowderived mesenchymal stem cells B Sen, Z Xie, N Case, WR Thompson, G Uzer, M Styner, J Rubin Journal of Bone and Mineral Research 29 (1), 78-89, 2014 | 158 | 2014 |
Mechanical loading regulates NFATc1 and β-catenin signaling through a GSK3β control node B Sen, M Styner, Z Xie, N Case, CT Rubin, J Rubin Journal of Biological Chemistry 284 (50), 34607-34617, 2009 | 156 | 2009 |
Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise M Styner, WR Thompson, K Galior, G Uzer, X Wu, S Kadari, N Case, Z Xie, ... Bone 64, 39-46, 2014 | 151 | 2014 |
Endothelial dysfunction: associations with exposure to ambient fine particles in diabetic individuals A Schneider, L Neas, MC Herbst, M Case, RW Williams, W Cascio, ... Environmental health perspectives 116 (12), 1666-1674, 2008 | 148 | 2008 |
Intranuclear actin regulates osteogenesis B Sen, Z Xie, G Uzer, WR Thompson, M Styner, X Wu, J Rubin Stem cells 33 (10), 3065-3076, 2015 | 139 | 2015 |
Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein N Case, J Thomas, B Sen, M Styner, Z Xie, K Galior, J Rubin Journal of Biological Chemistry 286 (45), 39450-39456, 2011 | 106 | 2011 |
Exercise decreases marrow adipose tissue through ßoxidation in obese running mice M Styner, GM Pagnotti, C McGrath, X Wu, B Sen, G Uzer, Z Xie, X Zong, ... Journal of Bone and Mineral Research 32 (8), 1692-1702, 2017 | 97 | 2017 |
Indomethacin promotes adipogenesis of mesenchymal stem cells through a cyclooxygenase independent mechanism M Styner, B Sen, Z Xie, N Case, J Rubin Journal of cellular biochemistry 111 (4), 1042-1050, 2010 | 95 | 2010 |
Mechanically induced focal adhesion assembly amplifies anti-adipogenic pathways in mesenchymal stem cells B Sen, C Guilluy, Z Xie, N Case, M Styner, J Thomas, I Oguz, C Rubin, ... Stem cells 29 (11), 1829-1836, 2011 | 93 | 2011 |
Mechanical activation of βcatenin regulates phenotype in adult murine marrowderived mesenchymal stem cells N Case, Z Xie, B Sen, M Styner, M Zou, C O'Conor, M Horowitz, J Rubin Journal of Orthopaedic Research 28 (11), 1531-1538, 2010 | 83 | 2010 |
Intranuclear actin structure modulates mesenchymal stem cell differentiation B Sen, G Uzer, RM Samsonraj, Z Xie, C McGrath, M Styner, A Dudakovic, ... Stem Cells 35 (6), 1624-1635, 2017 | 75 | 2017 |
Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells WR Thompson, C Guilluy, Z Xie, B Sen, KE Brobst, SS Yen, G Uzer, ... Stem cells 31 (11), 2528-2537, 2013 | 73 | 2013 |
Sun-mediated mechanical LINC between nucleus and cytoskeleton regulates βcatenin nuclear access G Uzer, G Bas, B Sen, Z Xie, S Birks, M Olcum, C McGrath, M Styner, ... Journal of biomechanics 74, 32-40, 2018 | 64 | 2018 |
Exercise regulation of marrow fat in the setting of PPARγ agonist treatment in female C57BL/6 mice M Styner, GM Pagnotti, K Galior, X Wu, WR Thompson, G Uzer, B Sen, ... Endocrinology 156 (8), 2753-2761, 2015 | 64 | 2015 |
Immune sensitization to yeast antigens in ASCA-positive patients with Crohn’s disease A Konrad, C Rütten, B Flogerzi, M Styner, B Göke, F Seibold Inflammatory bowel diseases 10 (2), 97-105, 2004 | 58 | 2004 |
Mechanical input restrains PPARγ2 expression and action to preserve mesenchymal stem cell multipotentiality N Case, J Thomas, Z Xie, B Sen, M Styner, D Rowe, J Rubin Bone 52 (1), 454-464, 2013 | 57 | 2013 |
βcatenin preserves the stem state of murine bone marrow stromal cells through activation of EZH2 B Sen, CR Paradise, Z Xie, J Sankaran, G Uzer, M Styner, M Meyer, ... Journal of Bone and Mineral Research 35 (6), 1149-1162, 2020 | 54 | 2020 |