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Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system T Serafini, SA Colamarino, ED Leonardo, H Wang, R Beddington, ... Cell 87 (6), 1001-1014, 1996 | 1525 | 1996 |
An LDL-receptor-related protein mediates Wnt signalling in mice KI Pinson, J Brennan, S Monkley, BJ Avery, WC Skarnes Nature 407 (6803), 535-538, 2000 | 1470 | 2000 |
High-throughput discovery of novel developmental phenotypes ME Dickinson, AM Flenniken, X Ji, L Teboul, MD Wong, JK White, ... Nature 537 (7621), 508-514, 2016 | 1080 | 2016 |
Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects B Shen, W Zhang, J Zhang, J Zhou, J Wang, L Chen, L Wang, A Hodgkins, ... Nature methods 11 (4), 399-402, 2014 | 978 | 2014 |
The knockout mouse project Nature genetics 36 (9), 921-924, 2004 | 762 | 2004 |
Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes A Gossler, AL Joyner, J Rossant, WC Skarnes Science 244 (4903), 463-465, 1989 | 658 | 1989 |
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes JK White, AK Gerdin, NA Karp, E Ryder, M Buljan, JN Bussell, J Salisbury, ... Cell 154 (2), 452-464, 2013 | 528 | 2013 |
Functional analysis of secreted and transmembrane proteins critical to mouse development KJ Mitchell, KI Pinson, OG Kelly, J Brennan, J Zupicich, P Scherz, ... Nature genetics 28 (3), 241-249, 2001 | 474 | 2001 |
Defining brain wiring patterns and mechanisms through gene trapping in mice PA Leighton, KJ Mitchell, LV Goodrich, X Lu, K Pinson, P Scherz, ... Nature 410 (6825), 174-179, 2001 | 464 | 2001 |
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Capturing genes encoding membrane and secreted proteins important for mouse development. WC Skarnes, JE Moss, SM Hurtley, RS Beddington Proceedings of the National Academy of Sciences 92 (14), 6592-6596, 1995 | 418 | 1995 |
A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. WC Skarnes, BA Auerbach, AL Joyner Genes & development 6 (6), 903-918, 1992 | 380 | 1992 |
ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a X Gao, P Tate, P Hu, R Tjian, WC Skarnes, Z Wang Proceedings of the National Academy of Sciences 105 (18), 6656-6661, 2008 | 378 | 2008 |
The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice OG Kelly, KI Pinson, WC Skarnes Oxford University Press for The Company of Biologists Limited 131 (12), 2803 …, 2004 | 360 | 2004 |
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators D Landeira, S Sauer, R Poot, M Dvorkina, L Mazzarella, HF Jørgensen, ... Nature cell biology 12 (6), 618-624, 2010 | 343 | 2010 |
Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform C Denning, V Borgdorff, J Crutchley, KSA Firth, V George, S Kalra, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1863 (7), 1728-1748, 2016 | 335 | 2016 |
The mammalian gene function resource: the International Knockout Mouse Consortium A Bradley, K Anastassiadis, A Ayadi, JF Battey, C Bell, MC Birling, ... Mammalian genome 23, 580-586, 2012 | 324 | 2012 |
The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse P Tate, W Skarnes, A Bird Nature genetics 12 (2), 205-208, 1996 | 307 | 1996 |