U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing T Okeyo-Owuor, BS White, R Chatrikhi, DR Mohan, S Kim, M Griffith, ... Leukemia 29 (4), 909-917, 2015 | 145 | 2015 |
Wild-type U2AF1 antagonizes the splicing program characteristic of U2AF1-mutant tumors and is required for cell survival DL Fei, H Motowski, R Chatrikhi, S Prasad, J Yu, S Gao, CL Kielkopf, ... PLoS Genetics 12 (10), e1006384, 2016 | 100 | 2016 |
An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal AA Agrawal, E Salsi, R Chatrikhi, S Henderson, JL Jenkins, MR Green, ... Nature communications 7 (1), 10950, 2016 | 73 | 2016 |
RNA binding protein CELF2 regulates signal-induced alternative polyadenylation by competing with enhancers of the polyadenylation machinery R Chatrikhi, MJ Mallory, MR Gazzara, LM Agosto, WS Zhu, AJ Litterman, ... Cell reports 28 (11), 2795-2806. e3, 2019 | 39 | 2019 |
Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia OD Rivera, MJ Mallory, M Quesnel-Vallières, R Chatrikhi, DC Schultz, ... Proceedings of the National Academy of Sciences 118 (15), e2014967118, 2021 | 35 | 2021 |
A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex R Chatrikhi, Feeney CF, Pulvino MJ, Alachouzos G, MacRae AJ, Falls Z, Rai S ... Cell Chemical Biology, 2021 | 30 | 2021 |
Reciprocal regulation of hnRNP C and CELF2 through translation and transcription tunes splicing activity in T cells MJ Mallory, SP McClory, R Chatrikhi, MR Gazzara, RJ Ontiveros, ... Nucleic acids research 48 (10), 5710-5719, 2020 | 24 | 2020 |
SF1 phosphorylation enhances specific binding to U2AF65 and reduces binding to 3′-splice-site RNA R Chatrikhi, W Wang, A Gupta, S Loerch, A Maucuer, CL Kielkopf Biophysical Journal 111 (12), 2570-2586, 2016 | 18 | 2016 |
A synthetic molecule stalls pre-mRNA splicing by enhancing cancer-relevant U2AF2–RNA complexes C. L. Kielkopf, C. F. Feeney, R. Chatrikhi, A. MacRae, G. Alachouzos, Z ... Acta Cryst. 75 (103), 2019 | | 2019 |
Understanding and Modulating RNA Recognition of Myelodysplasia-Relevant Pre-mRNA Splicing Factor U2AF35 R Chatrikhi University of Rochester School of Medicine and Dentistry (http://hdl.handle …, 2016 | | 2016 |