Low affinity binding site clusters confer hox specificity and regulatory robustness J Crocker, N Abe, L Rinaldi, AP McGregor, N Frankel, S Wang, ... Cell 160 (1), 191-203, 2015 | 380 | 2015 |
The Soft Touch: Low-Affinity Transcription Factor Binding Sites in Development and Evolution J Crocker, EPB Noon, DL Stern Current topics in developmental biology 117, 455-469, 2016 | 143 | 2016 |
Nuclear microenvironments modulate transcription from low-affinity enhancers A Tsai, AK Muthusamy, MRP Alves, LD Lavis, RH Singer, DL Stern, ... Elife 6, e28975, 2017 | 125 | 2017 |
Evolution acts on enhancer organization to fine-tune gradient threshold readouts J Crocker, Y Tamori, A Erives PLoS biology 6 (11), e263, 2008 | 107 | 2008 |
Accurate and sensitive quantification of protein-DNA binding affinity C Rastogi, HT Rube, JF Kribelbauer, J Crocker, RE Loker, GD Martini, ... Proceedings of the National Academy of Sciences 115 (16), E3692-E3701, 2018 | 99 | 2018 |
TALE-mediated modulation of transcriptional enhancers in vivo J Crocker, DL Stern Nature methods, 2013 | 89 | 2013 |
Multi-enhancer transcriptional hubs confer phenotypic robustness A Tsai, MRP Alves, J Crocker eLife, 8:e45325, 2019 | 80 | 2019 |
Genetic and Transgenic Reagents for Drosophila simulans, D. mauritiana, D. yakuba, D. santomea, and D. virilis DL Stern, J Crocker, Y Ding, N Frankel, G Kappes, E Kim, R Kuzmickas, ... G3: Genes, Genomes, Genetics 7 (4), 1339-1347, 2017 | 65 | 2017 |
Dense and pleiotropic regulatory information in a developmental enhancer T Fuqua, J Jordan, ME van Breugel, A Halavatyi, C Tischer, P Polidoro, ... Nature 587 (7833), 235-239, 2020 | 59 | 2020 |
Dynamic evolution of precise regulatory encodings creates the clustered site signature of enhancers J Crocker, N Potter, A Erives Nature communications 1 (1), 99, 2010 | 40 | 2010 |
A fully synthetic transcriptional platform for a multicellular eukaryote J Crocker, A Tsai, DL Stern Cell Reports 18 (1), 287-296, 2017 | 37 | 2017 |
Quantitatively predictable control of Drosophila transcriptional enhancers in vivo with engineered transcription factors J Crocker, GR Ilsley, DL Stern Nature genetics 48 (3), 292-298, 2016 | 37 | 2016 |
Using synthetic biology to study gene regulatory evolution J Crocker, GR Ilsley Current opinion in genetics & development 47, 91-101, 2017 | 32 | 2017 |
A Schnurri/Mad/Medea complex attenuates the Dorsal-Twist gradient readout at vnd J Crocker, A Erives Developmental biology, 2013 | 28 | 2013 |
A Closer Look at the eve Stripe 2 Enhancers of Drosophila and Themira J Crocker, A Erives PLoS genetics 4 (11), e1000276, 2008 | 27 | 2008 |
Enhancer architecture and chromatin accessibility constrain phenotypic space during Drosophila development R Galupa, G Alvarez-Canales, NO Borst, T Fuqua, L Gandara, N Misunou, ... Developmental Cell 58 (1), 51-62. e4, 2023 | 22 | 2023 |
Functional regulatory evolution outside of the minimal even-skipped stripe 2 enhancer J Crocker, DL Stern Development 144 (17), 3095-3101, 2017 | 17 | 2017 |
An open-source semi-automated robotics pipeline for embryo immunohistochemistry T Fuqua, J Jordan, A Halavatyi, C Tischer, K Richter, J Crocker Scientific Reports 11 (1), 10314, 2021 | 13 | 2021 |
Robust and efficient gene regulation through localized nuclear microenvironments A Tsai, R Galupa, J Crocker Development 147 (19), dev161430, 2020 | 13 | 2020 |
Developmental phenomics suggests that H3K4 monomethylation confers multi-level phenotypic robustness L Gandara, A Tsai, M Ekelöf, R Galupa, EPB Noon, T Alexandrov, ... Cell Reports 41 (11), 2022 | 9* | 2022 |