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Yudao Shen
Yudao Shen
SJTU/MSSM/UNC/SIOC/AHU
在 sjtu.edu.cn 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases
MS Eram, Y Shen, MM Szewczyk, H Wu, G Senisterra, F Li, KV Butler, ...
ACS chemical biology 11 (3), 772-781, 2016
2432016
Therapeutic targeting of RNA splicing catalysis through inhibition of protein arginine methylation
JY Fong, L Pignata, PA Goy, KC Kawabata, SCW Lee, CM Koh, D Musiani, ...
Cancer cell 36 (2), 194-209. e9, 2019
2172019
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
SX Lu, E De Neef, JD Thomas, E Sabio, B Rousseau, M Gigoux, DA Knorr, ...
Cell 184 (15), 4032-4047. e31, 2021
1642021
Cancer selective target degradation by folate-caged PROTACs
J Liu, H Chen, Y Liu, Y Shen, F Meng, HU Kaniskan, J Jin, W Wei
Journal of the American Chemical Society 143 (19), 7380-7387, 2021
1402021
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling
S Scheer, S Ackloo, TS Medina, M Schapira, F Li, JA Ward, AM Lewis, ...
Nature communications 10 (1), 19, 2019
1112019
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis
J Wang, X Yu, W Gong, X Liu, KS Park, A Ma, YH Tsai, Y Shen, T Onikubo, ...
Nature cell biology 24 (3), 384-399, 2022
1032022
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
X Yu, D Li, J Kottur, Y Shen, HS Kim, KS Park, YH Tsai, W Gong, J Wang, ...
Science translational medicine 13 (613), eabj1578, 2021
812021
Discovery of a potent, selective, and cell-active dual inhibitor of protein arginine methyltransferase 4 and protein arginine methyltransferase 6
Y Shen, MM Szewczyk, MS Eram, D Smil, HU Kaniskan, ...
Journal of medicinal chemistry 59 (19), 9124-9139, 2016
802016
Harnessing the E3 ligase KEAP1 for targeted protein degradation
J Wei, F Meng, KS Park, H Yim, J Velez, P Kumar, L Wang, L Xie, H Chen, ...
Journal of the American Chemical Society 143 (37), 15073-15083, 2021
792021
Discovery of First-in-class Protein Arginine Methyltransferase 5 (PRMT5) Degraders
Y Shen, G Gao, X Yu, HS Kim, L Wang, L Xie, M Schwarz, X Chen, ...
Journal of Medicinal Chemistry, 63 (17), 9977-9989, 2020
702020
PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia
X He, Y Zhu, YC Lin, M Li, J Du, H Dong, J Sun, L Zhu, H Wang, Z Ding, ...
Blood, The Journal of the American Society of Hematology 134 (6), 548-560, 2019
662019
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer
Q Wu, DY Nie, W Ba-Alawi, YS Ji, ZW Zhang, J Cruickshank, J Haight, ...
Nature chemical biology 18 (8), 821-830, 2022
522022
Discovery of G protein-biased D2 dopamine receptor partial agonists
X Chen, JD McCorvy, MG Fischer, KV Butler, Y Shen, BL Roth, J Jin
Journal of medicinal chemistry 59 (23), 10601-10618, 2016
522016
Smad6 methylation represses NFκB activation and periodontal inflammation
T Zhang, J Wu, N Ungvijanpunya, O Jackson-Weaver, Y Gou, J Feng, ...
Journal of Dental Research 97 (7), 810-819, 2018
442018
AKT degradation selectively inhibits the growth of PI3K/PTEN pathway–mutant cancers with wild-type KRAS and BRAF by destabilizing aurora kinase B
J Xu, X Yu, TC Martin, A Bansal, K Cheung, A Lubin, E Stratikopoulos, ...
Cancer discovery 11 (12), 3064-3089, 2021
402021
Design, synthesis, and evaluation of potent, selective, and bioavailable AKT kinase degraders
X Yu, J Xu, L Xie, L Wang, Y Shen, KM Cahuzac, X Chen, J Liu, ...
Journal of medicinal chemistry 64 (24), 18054-18081, 2021
322021
Discovery of a First-in-class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor
Y Shen, F Li, MM Szewczyk, L Halabelian, K Park, I Chau, A Dong, ...
Journal of Medicinal Chemistry 63 (10), 5477–5487, 2020
312020
Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia
Y Zhu, X He, YC Lin, H Dong, L Zhang, X Chen, Z Wang, Y Shen, M Li, ...
Blood, The Journal of the American Society of Hematology 134 (15), 1257-1268, 2019
312019
Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
D Li, X Yu, J Kottur, W Gong, Z Zhang, AJ Storey, YH Tsai, H Uryu, Y Shen, ...
Oncogene 41 (24), 3328-3340, 2022
302022
Targeting triple-negative breast cancer by a novel proteolysis targeting chimera degrader of enhancer of zeste homolog 2
B Dale, C Anderson, KS Park, HU Kaniskan, A Ma, Y Shen, C Zhang, ...
ACS Pharmacology & Translational Science 5 (7), 491-507, 2022
282022
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