| Telaprevir and peginterferon with or without ribavirin for chronic HCV infection C Hézode, N Forestier, G Dusheiko, P Ferenci, S Pol, T Goeser, ... New England Journal of Medicine 360 (18), 1839-1850, 2009 | 1340 | 2009 |
| Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir C Sarrazin, TL Kieffer, D Bartels, B Hanzelka, U Müh, M Welker, ... Gastroenterology 132 (5), 1767-1777, 2007 | 770 | 2007 |
| Structure of the hepatitis C virus RNA helicase domain N Yao, T Hesson, M Cable, Z Hong, AD Kwong, HV Le, PC Weber Nature structural biology 4 (6), 463-467, 1997 | 574 | 1997 |
| Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease RB Perni, SJ Almquist, RA Byrn, G Chandorkar, PR Chaturvedi, ... Antimicrobial agents and chemotherapy 50 (3), 899-909, 2006 | 473 | 2006 |
| Telaprevir and pegylated interferon–alpha‐2a inhibit wild‐type and resistant genotype 1 hepatitis C virus replication in patients TL Kieffer, C Sarrazin, JS Miller, MW Welker, N Forestier, HW Reesink, ... Hepatology 46 (3), 631-639, 2007 | 471 | 2007 |
| In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms C Lin, K Lin, YP Luong, BG Rao, YY Wei, DL Brennan, JR Fulghum, ... Journal of Biological Chemistry 279 (17), 17508-17514, 2004 | 409 | 2004 |
| Herpes simplex virus-infected cells contain a function (s) that destabilizes both host and viral mRNAs. AD Kwong, N Frenkel Proceedings of the National Academy of Sciences 84 (7), 1926-1930, 1987 | 401 | 1987 |
| Herpes simplex virus virion host shutoff function AD Kwong, JA Kruper, N Frenkel Journal of virology 62 (3), 912-921, 1988 | 366 | 1988 |
| Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3. 4A serine protease C Lin, AD Kwong, RB Perni Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious …, 2006 | 338 | 2006 |
| Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon W Markland, TJ McQuaid, J Jain, AD Kwong Antimicrobial agents and chemotherapy 44 (4), 859-866, 2000 | 333 | 2000 |
| The in vitro replication of DNA containing the SV40 origin. J Hurwitz, FB Dean, AD Kwong, SH Lee Journal of Biological Chemistry 265 (30), 18043-18046, 1990 | 321 | 1990 |
| Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus AD Kwong, RS Kauffman, P Hurter, P Mueller Nature biotechnology 29 (11), 993-1003, 2011 | 314 | 2011 |
| Studies on the activator 1 protein complex, an accessory factor for proliferating cell nuclear antigen-dependent DNA polymerase delta. SH Lee, AD Kwong, ZQ Pan, J Hurwitz Journal of Biological Chemistry 266 (1), 594-602, 1991 | 295 | 1991 |
| In vitro studies of cross-resistance mutations against two hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061 C Lin, CA Gates, BG Rao, DL Brennan, JR Fulghum, YP Luong, JD Frantz, ... Journal of Biological Chemistry 280 (44), 36784-36791, 2005 | 274 | 2005 |
| Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3· 4A protease inhibitors in treatment-naive subjects DJ Bartels, Y Zhou, EZ Zhang, M Marcial, RA Byrn, T Pfeiffer, AM Tigges, ... The Journal of infectious diseases 198 (6), 800-807, 2008 | 265 | 2008 |
| VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCV replicon cells K Lin, RB Perni, AD Kwong, C Lin Antimicrobial agents and chemotherapy 50 (5), 1813-1822, 2006 | 262 | 2006 |
| Synthesis of DNA by DNA polymerase epsilon in vitro. SH Lee, ZQ Pan, AD Kwong, PM Burgers, J Hurwitz Journal of Biological Chemistry 266 (33), 22707-22717, 1991 | 257 | 1991 |
| Viral and cellular RNA helicases as antiviral targets AD Kwong, BG Rao, KT Jeang Nature reviews Drug discovery 4 (10), 845-853, 2005 | 242 | 2005 |
| Site-specific cleavage/packaging of herpes simplex virus DNA and the selective maturation of nucleocapsids containing full-length viral DNA DA Vlazny, A Kwong, N Frenkel Proceedings of the National Academy of Sciences 79 (5), 1423-1427, 1982 | 224 | 1982 |
| The herpes simplex virus virion host shutoff function AD Kwong, N Frenkel Journal of virology 63 (11), 4834-4839, 1989 | 206 | 1989 |
