| The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism G Hoxhaj, BD Manning Nature Reviews Cancer 20 (2), 74-88, 2020 | 1432 | 2020 |
| Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome S Menon, CC Dibble, G Talbott, G Hoxhaj, AJ Valvezan, H Takahashi, ... Cell 156 (4), 771-785, 2014 | 853 | 2014 |
| mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle I Ben-Sahra, G Hoxhaj, SJH Ricoult, JM Asara, BD Manning Science 351 (6274), 728-733, 2016 | 772 | 2016 |
| Metformin inhibits hepatic mTORC1 signaling via dose-dependent mechanisms involving AMPK and the TSC complex JJ Howell, K Hellberg, M Turner, G Talbott, MJ Kolar, DS Ross, G Hoxhaj, ... Cell metabolism 25 (2), 463-471, 2017 | 368 | 2017 |
| Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans C Heintz, TK Doktor, A Lanjuin, CC Escoubas, Y Zhang, HJ Weir, S Dutta, ... Nature 541 (7635), 102-106, 2017 | 187 | 2017 |
| The mTORC1 signaling network senses changes in cellular purine nucleotide levels G Hoxhaj, J Hughes-Hallett, RC Timson, E Ilagan, M Yuan, JM Asara, ... Cell reports 21 (5), 1331-1346, 2017 | 179 | 2017 |
| Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase G Hoxhaj, I Ben-Sahra, SE Lockwood, RC Timson, V Byles, GT Henning, ... Science 363 (6431), 1088-1092, 2019 | 111 | 2019 |
| Mitochondrial NADP+ is essential for proline biosynthesis during cell growth DH Tran, R Kesavan, H Rion, MH Soflaee, A Solmonson, D Bezwada, ... Nature metabolism 3 (4), 571-585, 2021 | 75 | 2021 |
| ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome M Tinti, F Madeira, G Murugesan, G Hoxhaj, R Toth, C MacKintosh Database 2014, bat085, 2014 | 66 | 2014 |
| Effect of IRS4 levels on PI 3-kinase signalling G Hoxhaj, K Dissanayake, C MacKintosh PloS one 8 (9), e73327, 2013 | 47 | 2013 |
| An erythropoietin autocrine/paracrine axis modulates the growth and survival of human prostate cancer cells JY Jeong, G Hoxhaj, AL Socha, AJ Sytkowski, L Feldman Molecular Cancer Research 7 (7), 1150-1157, 2009 | 43 | 2009 |
| Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway MH Soflaee, R Kesavan, U Sahu, A Tasdogan, E Villa, Z Djabari, F Cai, ... Nature communications 13 (1), 2698, 2022 | 37 | 2022 |
| ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase G Hoxhaj, A Najafov, R Toth, DG Campbell, AR Prescott, C MacKintosh Journal of cell science 125 (19), 4662-4675, 2012 | 34 | 2012 |
| The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids G Hoxhaj, E Caddye, A Najafov, VP Houde, C Johnson, K Dissanayake, ... elife 5, e12278, 2016 | 27 | 2016 |
| Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets E Kavak, A Najafov, N Ozturk, T Seker, K Cavusoglu, T Aslan, AD Duru, ... Cellular signalling 22 (10), 1523-1535, 2010 | 25 | 2010 |
| Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin V Byles, Y Cormerais, K Kalafut, V Barrera, JEH Hallett, SH Sui, JM Asara, ... Molecular metabolism 53, 101309, 2021 | 21 | 2021 |
| MENA is a transcriptional target of the Wnt/beta-catenin pathway A Najafov, T Şeker, I Even, G Hoxhaj, O Selvi, DE Özel, A Koman, ... PLoS One 7 (5), e37013, 2012 | 21 | 2012 |
| PCR guru A Najafov, G Hoxhaj Amsterdam: Academic Press, Elsevier, 2017 | 12* | 2017 |
| Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation C Mary, MH Soflaee, R Kesavan, M Gelin, H Brown, G Zacharias, ... Molecular cell 82 (17), 3299-3311. e8, 2022 | 11 | 2022 |
| GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing DM Yu, J Zhao, EE Lee, D Kim, R Mahapatra, EK Rose, Z Zhou, C Hosler, ... The Journal of clinical investigation 133 (21), 2023 | 8 | 2023 |
