The molecular details of cytokine signaling via the JAK/STAT pathway R Morris, NJ Kershaw, JJ Babon Protein Science 27 (12), 1984-2009, 2018 | 671 | 2018 |
Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins IJ Clifton, MA McDonough, D Ehrismann, NJ Kershaw, N Granatino, ... Journal of inorganic biochemistry 100 (4), 644-669, 2006 | 525 | 2006 |
The molecular basis of JAK/STAT inhibition by SOCS1 NPD Liau, A Laktyushin, IS Lucet, JM Murphy, S Yao, E Whitlock, ... Nature communications 9 (1), 1558, 2018 | 373 | 2018 |
Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity JJ Babon, NJ Kershaw, JM Murphy, LN Varghese, A Laktyushin, ... Immunity 36 (2), 239-250, 2012 | 317 | 2012 |
SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition NJ Kershaw, JM Murphy, NPD Liau, LN Varghese, A Laktyushin, ... Nature structural & molecular biology 20 (4), 469-476, 2013 | 307 | 2013 |
α/β-Peptide foldamers targeting intracellular protein–protein interactions with activity in living cells JW Checco, EF Lee, M Evangelista, NJ Sleebs, K Rogers, ... Journal of the American Chemical Society 137 (35), 11365-11375, 2015 | 133 | 2015 |
Ribosomal oxygenases are structurally conserved from prokaryotes to humans R Chowdhury, R Sekirnik, NC Brissett, T Krojer, C Ho, SS Ng, IJ Clifton, ... Nature 510 (7505), 422-426, 2014 | 122 | 2014 |
RIPLET, and not TRIM25, is required for endogenous RIG‐I‐dependent antiviral responses TJ Hayman, AC Hsu, TB Kolesnik, LF Dagley, J Willemsen, MD Tate, ... Immunology and cell biology 97 (9), 840-852, 2019 | 92 | 2019 |
Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes Y Xu, NJ Kershaw, CS Luo, P Soo, MJ Pocock, PE Czabotar, DJ Hilton, ... Journal of Biological Chemistry 285 (28), 21214-21218, 2010 | 91 | 2010 |
Structure–function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum’s disease M Mukherji, W Chien, NJ Kershaw, IJ Clifton, CJ Schofield, AS Wierzbicki, ... Human molecular genetics 10 (18), 1971-1982, 2001 | 88 | 2001 |
Regulation of Janus kinases by SOCS proteins NJ Kershaw, JM Murphy, IS Lucet, NA Nicola, JJ Babon Biochemical Society Transactions 41 (4), 1042-1047, 2013 | 83 | 2013 |
Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis M Srivastava, G Duan, NJ Kershaw, V Athanasopoulos, JHC Yeo, T Ose, ... Nature communications 6 (1), 6253, 2015 | 74 | 2015 |
Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal α oxidation of phytanic acid M Mukherji, NJ Kershaw, CJ Schofield, AS Wierzbicki, MD Lloyd Chemistry & biology 9 (5), 597-605, 2002 | 72 | 2002 |
Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation JS Scotti, IKH Leung, W Ge, MA Bentley, J Paps, HB Kramer, J Lee, ... Proceedings of the National Academy of Sciences 111 (37), 13331-13336, 2014 | 69 | 2014 |
Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation RR Ramiscal, IA Parish, RS Lee-Young, JJ Babon, J Blagih, A Pratama, ... Elife 4, e08698, 2015 | 59 | 2015 |
Crystal structure of the TRIM25 B30. 2 (PRYSPRY) domain: a key component of antiviral signalling AA D’Cruz, NJ Kershaw, JJ Chiang, MK Wang, NA Nicola, JJ Babon, ... Biochemical journal 456 (2), 231-240, 2013 | 57 | 2013 |
Independent interactions of phosphorylated β-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions MC Faux, JL Coates, NJ Kershaw, MJ Layton, AW Burgess PloS one 5 (11), e14127, 2010 | 55 | 2010 |
The enzymology of clavam and carbapenem biosynthesis NJ Kershaw, MEC Caines, MC Sleeman, CJ Schofield Chemical communications, 4251-4263, 2005 | 53 | 2005 |
ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid H Arulanantham, NJ Kershaw, KS Hewitson, CE Hughes, JE Thirkettle, ... Journal of Biological Chemistry 281 (1), 279-287, 2006 | 51 | 2006 |
Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates NJ Kershaw, A Laktyushin, NA Nicola, JJ Babon Growth Factors 32 (1), 1-10, 2014 | 47 | 2014 |