A novel multiple-stage antimalarial agent that inhibits protein synthesis B Baragaña, I Hallyburton, MCS Lee, NR Norcross, R Grimaldi, TD Otto, ... Nature 522 (7556), 315-320, 2015 | 445 | 2015 |
Challenges and recent progress in drug discovery for tropical diseases M De Rycker, B Baragaña, SL Duce, IH Gilbert Nature 559 (7715), 498-506, 2018 | 200 | 2018 |
High Diastereoselective Synthesis of Threo or Erythro Aminoalkyl Epoxides from. alpha.-Amino Acids J Barluenga, B Baragana, JM Concellon The Journal of Organic Chemistry 60 (21), 6696-6699, 1995 | 154 | 1995 |
Protease-catalyzed peptide synthesis on solid support RV Ulijn, B Baragaña, PJ Halling, SL Flitsch Journal of the American Chemical Society 124 (37), 10988-10989, 2002 | 134 | 2002 |
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis B Baragaña, B Forte, R Choi, S Nakazawa Hewitt, JA Bueren-Calabuig, ... Proceedings of the National Academy of Sciences 116 (14), 7015-7020, 2019 | 109 | 2019 |
Enantioselective transport by a steroidal guanidinium receptor B Baragaña, AG Blackburn, P Breccia, AP Davis, J De Mendoza, ... Chemistry–A European Journal 8 (13), 2931-2936, 2002 | 86 | 2002 |
Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy B Baragaña, NR Norcross, C Wilson, A Porzelle, I Hallyburton, R Grimaldi, ... Journal of medicinal chemistry 59 (21), 9672-9685, 2016 | 81 | 2016 |
Differentially-protected steroidal triamines; scaffolds with potential for medicinal, supramolecular, and combinatorial chemistry V Del Amo, L Siracusa, T Markidis, B Baragaña, KM Bhattarai, ... Organic & biomolecular chemistry 2 (22), 3320-3328, 2004 | 74 | 2004 |
MalDA, accelerating malaria drug discovery T Yang, S Ottilie, ES Istvan, KP Godinez-Macias, AK Lukens, B Baragaña, ... Trends in parasitology 37 (6), 493-507, 2021 | 63 | 2021 |
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase SN Hewitt, DM Dranow, BG Horst, JA Abendroth, B Forte, I Hallyburton, ... ACS infectious diseases 3 (1), 34-44, 2017 | 56 | 2017 |
Prioritization of molecular targets for antimalarial drug discovery B Forte, S Ottilie, A Plater, B Campo, KJ Dechering, FJ Gamo, ... ACS infectious diseases 7 (10), 2764-2776, 2021 | 47 | 2021 |
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention RL Summers, CFA Pasaje, JP Pisco, J Striepen, MR Luth, K Kumpornsin, ... Cell chemical biology 29 (2), 191-201. e8, 2022 | 45 | 2022 |
Design, Synthesis, and Evaluation of 5′‐Diphenyl Nucleoside Analogues as Inhibitors of the Plasmodium falciparum dUTPase SE Hampton, B Baragaña, A Schipani, C Bosch‐Navarrete, ... ChemMedChem 6 (10), 1816-1831, 2011 | 40 | 2011 |
The first direct preparation of chiral functionalised ketones and their synthetic uses J Barluenga, B BaragañA, A Alonso, JM Concellón Journal of the Chemical Society, Chemical Communications, 969-970, 1994 | 36 | 1994 |
β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase B Baragaña, O McCarthy, P Sánchez, C Bosch-Navarrete, M Kaiser, ... Bioorganic & medicinal chemistry 19 (7), 2378-2391, 2011 | 29 | 2011 |
Preparation and Synthetic Applications of Enantiopure (2S,3S)- or (2R,3S)-2-Halomethyl-1,2-epoxyalkan-3-amines J Barluenga, B Baragana, JM Concellón The Journal of Organic Chemistry 64 (8), 2843-2846, 1999 | 27 | 1999 |
Synthetic applications of 1-aminoalkyl chloromethyl ketones. Synthesis of enantiopure 3-azetidinols and aminoalkyl epoxides J Barluenga, B Baragaña, JM Concellón The Journal of Organic Chemistry 62 (17), 5974-5977, 1997 | 27 | 1997 |
Synthesis of Enantiopure α ‘-Amino α, β-Epoxy Ketones from α ‘-Amino Bromomethyl Ketones J Barluenga, B Baragana, JM Concellón, A Piñera-Nicolás, MR Díaz, ... The Journal of Organic Chemistry 64 (14), 5048-5052, 1999 | 25 | 1999 |
Screening a protein kinase inhibitor library against Plasmodium falciparum I Hallyburton, R Grimaldi, A Woodland, B Baragaña, T Luksch, D Spinks, ... Malaria journal 16, 1-11, 2017 | 23 | 2017 |
Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif N Klee, PE Wong, B Baragaña, F El Mazouni, MA Phillips, MP Barrett, ... Bioorganic & medicinal chemistry letters 20 (15), 4364-4366, 2010 | 20 | 2010 |