A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum S Varadarajan, ETW Bampton, JL Smalley, K Tanaka, RE Caves, ... Cell Death & Differentiation 19 (12), 1896-1907, 2012 | 69 | 2012 |
Adaptive and behavioral changes in kynurenine 3-monooxygenase knockout mice: relevance to psychotic disorders S Erhardt, A Pocivavsek, M Repici, XC Liu, S Imbeault, DC Maddison, ... Biological psychiatry 82 (10), 756-765, 2017 | 64 | 2017 |
Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase L Miller-Fleming, P Antas, TF Pais, JL Smalley, F Giorgini, TF Outeiro Proceedings of the National Academy of Sciences 111 (19), 7012-7017, 2014 | 61 | 2014 |
Application of connectivity mapping in predictive toxicology based on gene-expression similarity JL Smalley, TW Gant, SD Zhang Toxicology 268 (3), 143-146, 2010 | 61 | 2010 |
Locally reducing KCC2 activity in the hippocampus is sufficient to induce temporal lobe epilepsy MR Kelley, RA Cardarelli, JL Smalley, TA Ollerhead, PM Andrew, ... EBioMedicine 32, 62-71, 2018 | 58 | 2018 |
Neuroinflammation and ER-stress are key mechanisms of acute bilirubin toxicity and hearing loss in a mouse model E Schiavon, JL Smalley, S Newton, NH Greig, ID Forsythe PLoS One 13 (8), e0201022, 2018 | 51 | 2018 |
Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse SJ Lucas, CB Michel, V Marra, JL Smalley, MH Hennig, BP Graham, ... The Journal of physiology 596 (9), 1699-1721, 2018 | 35 | 2018 |
Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis S Varadarajan, K Tanaka, JL Smalley, ETW Bampton, M Pellecchia, ... PLoS One 8 (2), e56603, 2013 | 34 | 2013 |
Isolation and characterization of multi-protein complexes enriched in the K-Cl Co-transporter 2 from brain plasma membranes JL Smalley, G Kontou, C Choi, Q Ren, D Albrecht, K Abiraman, ... Frontiers in Molecular Neuroscience 13, 563091, 2020 | 25 | 2020 |
Identification of a core amino acid motif within the α subunit of GABAARs that promotes inhibitory synaptogenesis and resilience to seizures AJ Nathanson, Y Zhang, JL Smalley, TA Ollerhead, MAR Santos, ... Cell reports 28 (3), 670-681. e8, 2019 | 23 | 2019 |
Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice R Jarvis, SFJ Ng, AJ Nathanson, RA Cardarelli, K Abiraman, F Wade, ... Cell Reports Medicine 4 (3), 2023 | 21 | 2023 |
The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration S Varadarajan, C Breda, JL Smalley, M Butterworth, SN Farrow, F Giorgini, ... Cell Death & Differentiation 22 (8), 1388-1396, 2015 | 21 | 2015 |
KCC2 is required for the survival of mature neurons but not for their development G Kontou, SFJ Ng, RA Cardarelli, JH Howden, C Choi, Q Ren, ... Journal of Biological Chemistry 296, 2021 | 19 | 2021 |
Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington’s disease models JL Smalley, C Breda, RP Mason, G Kooner, R Luthi-Carter, TW Gant, ... Journal of Molecular Medicine 94, 235-245, 2016 | 19 | 2016 |
Nanoengineered disruption of heat shock protein 90 targets drug-induced resistance and relieves natural killer cell suppression in breast cancer M Smalley, SK Natarajan, J Mondal, D Best, D Goldman, B Shanthappa, ... Cancer research 80 (23), 5355-5366, 2020 | 15 | 2020 |
Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr128Ala variant (rs2257020) in Xenopus oocytes N Madjroh, PA Davies, JL Smalley, U Kristiansen, PC Söderhielm, ... Pharmacological research 169, 105653, 2021 | 7 | 2021 |
The K-Cl co-transporter 2 is a point of convergence for multiple autism spectrum disorder and epilepsy risk gene products JL Smalley, G Kontou, C Choi, Q Ren, D Albrecht, K Abiraman, ... bioRxiv, 2020.03. 02.973859, 2020 | 5 | 2020 |
Analyzing the mechanisms that facilitate the subtype-specific assembly of γ-aminobutyric acid type A receptors C Choi, JL Smalley, AHS Lemons, Q Ren, CE Bope, JS Dengler, ... Frontiers in Molecular Neuroscience 15, 1017404, 2022 | 4 | 2022 |
A computationally inspired in-vivo approach identifies a link between amygdalar transcriptional heterogeneity, socialization and anxiety A Goldman, JL Smalley, M Mistry, H Krenzlin, H Zhang, A Dhawan, ... Translational Psychiatry 9 (1), 336, 2019 | 4 | 2019 |
Spectrin-beta 2 facilitates the selective accumulation of GABAA receptors at somatodendritic synapses JL Smalley, N Cho, SFJ Ng, C Choi, AHS Lemons, S Chaudry, CE Bope, ... Communications Biology 6 (1), 11, 2023 | 3 | 2023 |