Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel SG Brohawn, J Del Mármol, R MacKinnon Science 335 (6067), 436-441, 2012 | 469 | 2012 |
Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels SG Brohawn, Z Su, R MacKinnon Proceedings of the National Academy of Sciences 111 (9), 3614-3619, 2014 | 398 | 2014 |
Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel SG Brohawn, EB Campbell, R MacKinnon Nature 516 (7529), 126-130, 2014 | 323 | 2014 |
New water-soluble phosphines as reductants of peptide and protein disulfide bonds: reactivity and membrane permeability DJ Cline, SE Redding, SG Brohawn, JN Psathas, JP Schneider, C Thorpe Biochemistry 43 (48), 15195-15203, 2004 | 258 | 2004 |
Precise multimodal optical control of neural ensemble activity AR Mardinly, IA Oldenburg, NC Pégard, S Sridharan, EH Lyall, ... Nature neuroscience 21 (6), 881-893, 2018 | 253 | 2018 |
Structural evidence for common ancestry of the nuclear pore complex and vesicle coats SG Brohawn, NC Leksa, ED Spear, KR Rajashankar, TU Schwartz Science 322 (5906), 1369-1373, 2008 | 227 | 2008 |
The nuclear pore complex has entered the atomic age SG Brohawn, JR Partridge, JRR Whittle, TU Schwartz Structure 17 (9), 1156-1168, 2009 | 217 | 2009 |
Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs DM Kern, B Sorum, SS Mali, CM Hoel, S Sridharan, JP Remis, DB Toso, ... Nature structural & molecular biology 28 (7), 573-582, 2021 | 205 | 2021 |
Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel SG Brohawn, EB Campbell, R MacKinnon Proceedings of the National Academy of Sciences 110 (6), 2129-2134, 2013 | 130 | 2013 |
A global benchmark study using affinity-based biosensors RL Rich, GA Papalia, PJ Flynn, J Furneisen, J Quinn, JS Klein, ... Analytical biochemistry 386 (2), 194-216, 2009 | 124 | 2009 |
How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2 SG Brohawn Annals of the New York Academy of Sciences 1352 (1), 20-32, 2015 | 119 | 2015 |
Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs DM Kern, B Sorum, SS Mali, CM Hoel, S Sridharan, JP Remis, DB Toso, ... BioRxiv, 2020 | 103 | 2020 |
Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs DM Kern, SC Oh, RK Hite, SG Brohawn Elife 8, e42636, 2019 | 102 | 2019 |
Molecular architecture of the Nup84–Nup145C–Sec13 edge element in the nuclear pore complex lattice SG Brohawn, TU Schwartz Nature structural & molecular biology 16 (11), 1173-1177, 2009 | 96 | 2009 |
The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier SG Brohawn, W Wang, A Handler, EB Campbell, JR Schwarz, ... Elife 8, e50403, 2019 | 91 | 2019 |
Ultrasound activates mechanosensitive TRAAK K+ channels through the lipid membrane B Sorum, RA Rietmeijer, K Gopakumar, H Adesnik, SG Brohawn Proceedings of the National Academy of Sciences 118 (6), e2006980118, 2021 | 90 | 2021 |
High-performance microbial opsins for spatially and temporally precise perturbations of large neuronal networks S Sridharan, MA Gajowa, MB Ogando, UK Jagadisan, L Abdeladim, ... Neuron 110 (7), 1139-1155. e6, 2022 | 68 | 2022 |
The structure of the scaffold nucleoporin Nup120 reveals a new and unexpected domain architecture NC Leksa, SG Brohawn, TU Schwartz Structure 17 (8), 1082-1091, 2009 | 67 | 2009 |
Structural basis for pH gating of the two-pore domain K+ channel TASK2 B Li, RA Rietmeijer, SG Brohawn Nature 586 (7829), 457-462, 2020 | 57 | 2020 |
Structure of SARS-CoV-2 M protein in lipid nanodiscs KA Dolan, M Dutta, DM Kern, A Kotecha, GA Voth, SG Brohawn Elife 11, e81702, 2022 | 47 | 2022 |