| Direct observation of the interconversion of normal and toxic forms of α-synuclein N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, ... Cell 149 (5), 1048-1059, 2012 | 969 | 2012 |
| Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, ... Proceedings of the National Academy of Sciences 112 (16), E1994-E2003, 2015 | 553 | 2015 |
| The CamSol method of rational design of protein mutants with enhanced solubility P Sormanni, FA Aprile, M Vendruscolo Journal of molecular biology 427 (2), 478-490, 2015 | 415 | 2015 |
| A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ... Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017 | 308 | 2017 |
| Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, ... Nature communications 10 (1), 1541, 2019 | 175 | 2019 |
| Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, ... Science advances 3 (6), e1700488, 2017 | 146 | 2017 |
| Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins P Sormanni, FA Aprile, M Vendruscolo Proceedings of the National Academy of Sciences 112 (32), 9902-9907, 2015 | 143 | 2015 |
| Targeting amyloid aggregation: an overview of strategies and mechanisms S Giorgetti, C Greco, P Tortora, FA Aprile International journal of molecular sciences 19 (9), 2677, 2018 | 140 | 2018 |
| Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbjörner, ... Journal of molecular biology 425 (14), 2397-2411, 2013 | 127 | 2013 |
| Microfluidic diffusion analysis of the sizes and interactions of proteins under native solution conditions P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, ... ACS nano 10 (1), 333-341, 2016 | 123 | 2016 |
| Third generation antibody discovery methods: in silico rational design P Sormanni, FA Aprile, M Vendruscolo Chemical Society Reviews 47 (24), 9137-9157, 2018 | 118 | 2018 |
| Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ... ACS chemical biology 13 (8), 2308-2319, 2018 | 108 | 2018 |
| Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, ... Science advances 6 (45), eabb5924, 2020 | 107 | 2020 |
| The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation FA Aprile, E Källstig, G Limorenko, M Vendruscolo, D Ron, C Hansen Scientific reports 7 (1), 9039, 2017 | 92 | 2017 |
| Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain FA Aprile, A Dhulesia, F Stengel, C Roodveldt, JLP Benesch, P Tortora, ... PLoS One 8 (6), e67961, 2013 | 91 | 2013 |
| Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, ... Acta neuropathologica communications 7, 1-13, 2019 | 87 | 2019 |
| Rational design of a conformation-specific antibody for the quantification of Aβ oligomers FA Aprile, P Sormanni, M Podpolny, S Chhangur, LM Needham, ... Proceedings of the National Academy of Sciences 117 (24), 13509-13518, 2020 | 75 | 2020 |
| Methods of probing the interactions between small molecules and disordered proteins GT Heller, FA Aprile, M Vendruscolo Cellular and Molecular Life Sciences 74, 3225-3243, 2017 | 65 | 2017 |
| Sequence specificity in the entropy-driven binding of a small molecule and a disordered peptide GT Heller, FA Aprile, M Bonomi, C Camilloni, A De Simone, ... Journal of molecular biology 429 (18), 2772-2779, 2017 | 64 | 2017 |
| Inhibition of α-synuclein fibril elongation by Hsp70 is governed by a kinetic binding competition between α-synuclein species FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, ... Biochemistry 56 (9), 1177-1180, 2017 | 60 | 2017 |
