Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid N Ijssennagger, AWF Janssen, A Milona, JMR Pittol, DAA Hollman, ... Journal of Hepatology 64 (5), 1158-1166, 2016 | 94 | 2016 |
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling MT Prentzell, U Rehbein, MC Sandoval, AS De Meulemeester, ... Cell 184 (3), 655-674. e27, 2021 | 93 | 2021 |
Splenic dendritic cell involvement in FXR-mediated amelioration of DSS colitis V Massafra, N Ijssennagger, M Plantinga, A Milona, JMR Pittol, M Boes, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1862 (2), 166-173, 2016 | 67 | 2016 |
Farnesoid X receptor activation promotes hepatic amino acid catabolism and ammonium clearance in mice V Massafra, A Milona, HR Vos, RJJ Ramos, J Gerrits, ECL Willemsen, ... Gastroenterology 152 (6), 1462-1476. e10, 2017 | 66 | 2017 |
FXR isoforms control different metabolic functions in liver cells via binding to specific DNA motifs JMR Pittol, A Milona, I Morris, ECL Willemsen, SW van der Veen, ... Gastroenterology 159 (5), 1853-1865. e10, 2020 | 62 | 2020 |
Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity M Abdellatif, V Trummer-Herbst, AM Heberle, A Humnig, T Pendl, ... Circulation 145 (25), 1853-1866, 2022 | 53 | 2022 |
Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors JM Ramos Pittol, A Oruba, G Mittler, S Saccani, D van Essen PLoS biology 16 (5), e2004526, 2018 | 40 | 2018 |
The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression ITGW Bijsmans, C Guercini, JM Ramos Pittol, W Omta, A Milona, ... Scientific reports 5 (1), 14086, 2015 | 31 | 2015 |
Steroidogenic control of liver metabolism through a nuclear receptor-network A Milona, V Massafra, H Vos, J Naik, N Artigas, HAB Paterson, ... Molecular metabolism 30, 221-229, 2019 | 17 | 2019 |
Ablation of liver Fxr results in an increased colonic mucus barrier in mice N Ijssennagger, KS van Rooijen, S Magnúsdóttir, JMR Pittol, ... JHEP Reports 3 (5), 100344, 2021 | 14 | 2021 |
The Pseudokinase TRIB3 negatively regulates the HER2 receptor pathway and is a biomarker of good prognosis in luminal breast cancer A Orea-Soufi, S Castillo-Lluva, N Salvador-Tormo, P Martín-Cabrera, ... Cancers 13 (21), 5307, 2021 | 13 | 2021 |
mTORC1 crosstalk with stress granules in aging and age-related diseases M Cadena Sandoval, AM Heberle, U Rehbein, C Barile, JM Ramos Pittol, ... Frontiers in aging 2, 761333, 2021 | 12 | 2021 |
Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation E Mocholi, L Russo, K Gopal, AG Ramstead, SM Hochrein, HR Vos, ... Cell Reports 42 (6), 2023 | 11 | 2023 |
Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology ITGW Bijsmans, A Milona, N Ijssennagger, ECL Willemsen, JMR Pittol, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (3), 687-700, 2017 | 10 | 2017 |
Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool D Passeri, A Carotti, JMR Pittol, G Ciaccioli, R Pellicciari, SWC van Mil, ... Medchemcomm 10 (8), 1412-1419, 2019 | 7 | 2019 |
PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation MS Madsen, MF Broekema, MR Madsen, A Koppen, A Borgman, C Gräwe, ... Nature Communications 13 (1), 7090, 2022 | 6 | 2022 |
Peroxynitrite is involved in the apoptotic death of cultured cerebellar granule neurons induced by staurosporine, but not by potassium deprivation M Olguín-Albuerne, JM Ramos-Pittol, A Coyoy, CP Martínez-Briseño, ... Neurochemical research 41, 316-327, 2016 | 6 | 2016 |
Rifaximin stimulates nitrogen detoxification by PXR‐independent mechanisms in human small intestinal organoids K de Wit, U Beuers, A Mukha, ECA Stigter, MC Gulersonmez, ... Liver International 43 (3), 649-659, 2023 | 5 | 2023 |
Robust synthesis of 2′-azido modified RNA from 2′-amino precursors by diazotransfer reaction S Moreno, JMR Pittol, M Hartl, R Micura Organic & Biomolecular Chemistry 20 (39), 7845-7850, 2022 | 5 | 2022 |
Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice JM Ramos-Pittol, I Fernandes-Freitas, A Milona, SM Manchishi, ... Nature Communications 14 (1), 3076, 2023 | 2 | 2023 |