HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia J Kim, I Tchernyshyov, GL Semenza, CV Dang Cell metabolism 3 (3), 177-185, 2006 | 4277 | 2006 |
Cancer's molecular sweet tooth and the Warburg effect J Kim, CV Dang Cancer research 66 (18), 8927-8930, 2006 | 1536 | 2006 |
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells R Fukuda, H Zhang, J Kim, L Shimoda, CV Dang, GL Semenza Cell 129 (1), 111-122, 2007 | 1460 | 2007 |
Multifaceted roles of glycolytic enzymes J Kim, CV Dang Trends in biochemical sciences 30 (3), 142-150, 2005 | 828 | 2005 |
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1 J Kim, P Gao, YC Liu, GL Semenza, CV Dang Molecular and cellular biology, 2007 | 753 | 2007 |
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis F Li, Y Wang, KI Zeller, JJ Potter, DR Wonsey, KA O'Donnell, J Kim, ... Molecular and cellular biology, 2005 | 735 | 2005 |
The interplay between MYC and HIF in cancer CV Dang, J Kim, P Gao, J Yustein Nature Reviews Cancer 8 (1), 51-56, 2008 | 723 | 2008 |
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis N Takeda, EL O'Dea, A Doedens, J Kim, A Weidemann, C Stockmann, ... Genes & development 24 (5), 491-501, 2010 | 687 | 2010 |
Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity YS Lee, J Kim, O Osborne, R Sasik, S Schenk, A Chen, H Chung, ... Cell 157 (6), 1339-1352, 2014 | 578 | 2014 |
MUC1 and HIF-1alpha signaling crosstalk induces anabolic glucose metabolism to impart gemcitabine resistance to pancreatic cancer SK Shukla, V Purohit, K Mehla, V Gunda, NV Chaika, E Vernucci, RJ King, ... Cancer cell 32 (1), 71-87. e7, 2017 | 490 | 2017 |
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression J Chou, JH Lin, A Brenot, J Kim, S Provot, Z Werb Nature cell biology 15 (2), 201-213, 2013 | 428 | 2013 |
Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays J Kim, KI Zeller, Y Wang, AG Jegga, BJ Aronow, KA O'Donnell, CV Dang Molecular and cellular biology 24 (13), 5923-5936, 2004 | 417 | 2004 |
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity H Semba, N Takeda, T Isagawa, Y Sugiura, K Honda, M Wake, ... Nature communications 7 (1), 11635, 2016 | 301 | 2016 |
Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis KA O'Donnell, D Yu, KI Zeller, J Kim, F Racke, A Thomas-Tikhonenko, ... Molecular and cellular biology 26 (6), 2373-2386, 2006 | 287 | 2006 |
Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1 RJ Ruthenborg, JJ Ban, A Wazir, N Takeda, J Kim Molecules and cells 37 (9), 637-643, 2014 | 235 | 2014 |
Effects of hypoxia on tumor metabolism J Kim, P Gao, CV Dang Cancer and Metastasis Reviews 26, 291-298, 2007 | 198 | 2007 |
Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart R Mao, X Wang, EL Spitznagel, LP Frelin, JC Ting, H Ding, J Kim, ... Genome biology 6, 1-20, 2005 | 196 | 2005 |
GATA-3 and the regulation of the mammary luminal cell fate H Kouros-Mehr, J Kim, SK Bechis, Z Werb Current opinion in cell biology 20 (2), 164-170, 2008 | 185 | 2008 |
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition J Goodwin, ML Neugent, SY Lee, JH Choe, H Choi, DMR Jenkins, ... Nature communications 8 (1), 15503, 2017 | 160 | 2017 |
NQO1 inhibits proteasome-mediated degradation of HIF-1α ET Oh, J Kim, JM Kim, SJ Kim, JS Lee, SS Hong, J Goodwin, ... Nature communications 7 (1), 13593, 2016 | 153 | 2016 |