| Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 … XL Du, D Edelstein, L Rossetti, IG Fantus, H Goldberg, F Ziyadeh, J Wu, ... Proceedings of the National Academy of Sciences 97 (22), 12222-12226, 2000 | 1500 | 2000 |
| Metformin is an AMP kinase–dependent growth inhibitor for breast cancer cells M Zakikhani, R Dowling, IG Fantus, N Sonenberg, M Pollak Cancer research 66 (21), 10269-10273, 2006 | 1328 | 2006 |
| Metformin inhibits mammalian target of rapamycin–dependent translation initiation in breast cancer cells RJO Dowling, M Zakikhani, IG Fantus, M Pollak, N Sonenberg Cancer research 67 (22), 10804-10812, 2007 | 1129 | 2007 |
| Oral antihyperglycemic therapy for type 2 diabetes mellitus AYY Cheng, IG Fantus Cmaj 172 (2), 213-226, 2005 | 793 | 2005 |
| The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species Y Lin, AH Berg, P Iyengar, TKT Lam, A Giacca, TP Combs, MW Rajala, ... Journal of biological chemistry 280 (6), 4617-4626, 2005 | 683 | 2005 |
| Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. BI Posner, R Faure, JW Burgess, AP Bevan, D Lachance, G Zhang-Sun, ... Journal of Biological Chemistry 269 (6), 4596-4604, 1994 | 661 | 1994 |
| Mechanisms of the free fatty acid-induced increase in hepatic glucose production TKT Lam, A Carpentier, GF Lewis, G van de Werve, IG Fantus, A Giacca American Journal of Physiology-Endocrinology and Metabolism 284 (5), E863-E873, 2003 | 411 | 2003 |
| Insulin and related factors in premenopausal breast cancer risk ME Del Giudice, IG Fantus, S Ezzat, G McKeown-Eyssen, D Page, ... Breast cancer research and treatment 47, 111-120, 1998 | 386 | 1998 |
| Circulating tumor necrosis factor-α concentrations in a native Canadian population with high rates of type 2 diabetes mellitus B Zinman, AJG Hanley, SB Harris, J Kwan, IG Fantus The journal of clinical endocrinology & metabolism 84 (1), 272-278, 1999 | 380 | 1999 |
| Pervanadate [peroxide (s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase IG Fantus, S Kadota, G Deragon, B Foster, BI Posner Biochemistry 28 (22), 8864-8871, 1989 | 377 | 1989 |
| Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes W Shao, Z Yu, Y Chiang, Y Yang, T Chai, W Foltz, H Lu, IG Fantus, T Jin PloS one 7 (1), e28784, 2012 | 340 | 2012 |
| N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress CA Haber, TKT Lam, Z Yu, N Gupta, T Goh, E Bogdanovic, A Giacca, ... American Journal of Physiology-Endocrinology and Metabolism 285 (4), E744-E753, 2003 | 337 | 2003 |
| Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus S Koren, IG Fantus Best practice & research Clinical endocrinology & metabolism 21 (4), 621-640, 2007 | 311 | 2007 |
| Insulin-lowering effects of metformin in women with early breast cancer PJ Goodwin, KI Pritchard, M Ennis, M Clemons, M Graham, IG Fantus Clinical breast cancer 8 (6), 501-505, 2008 | 306 | 2008 |
| Glomerular structure and function require paracrine, not autocrine, VEGF–VEGFR-2 signaling K Sison, V Eremina, H Baelde, W Min, M Hirashima, IG Fantus, ... Journal of the American Society of Nephrology 21 (10), 1691-1701, 2010 | 303 | 2010 |
| Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a … C Taghibiglou, F Rashid-Kolvear, SC Van Iderstine, H Le-Tien, IG Fantus, ... Journal of Biological Chemistry 277 (1), 793-803, 2002 | 295 | 2002 |
| Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-δ TKT Lam, H Yoshii, CA Haber, E Bogdanovic, L Lam, IG Fantus, A Giacca American Journal of Physiology-Endocrinology and Metabolism 283 (4), E682-E691, 2002 | 279 | 2002 |
| Free fatty acid–induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo AI Oprescu, G Bikopoulos, A Naassan, EM Allister, C Tang, E Park, ... Diabetes 56 (12), 2927-2937, 2007 | 275 | 2007 |
| Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of β-catenin T Jin, IG Fantus, J Sun Cellular signalling 20 (10), 1697-1704, 2008 | 272 | 2008 |
| Peroxide (s) of vanadium: a novel and potent insulin-mimetic agent which activates the insulin receptor kinase S Kadota, IG Fantus, G Deragon, HJ Guyda, B Hersh, BI Posner Biochemical and biophysical research communications 147 (1), 259-266, 1987 | 223 | 1987 |
