Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo [1, 2-a] pyridine symbiotic prototypes RB Lacerda, CKF de Lima, LL da Silva, NC Romeiro, ALP Miranda, ... Bioorganic & medicinal chemistry 17 (1), 74-84, 2009 | 234 | 2009 |
Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates NC Romeiro, G Aguirre, P Hernández, M González, H Cerecetto, I Aldana, ... Bioorganic & medicinal chemistry 17 (2), 641-652, 2009 | 151 | 2009 |
Design, Synthesis, and Pharmacological Evaluation of N-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally … AE Kümmerle, M Schmitt, SVS Cardozo, C Lugnier, P Villa, AB Lopes, ... Journal of medicinal chemistry 55 (17), 7525-7545, 2012 | 119 | 2012 |
Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease LFN Lemes, G de Andrade Ramos, AS De Oliveira, FMR Da Silva, ... European Journal of Medicinal Chemistry 108, 687-700, 2016 | 99 | 2016 |
2-Acetylpyridine thiosemicarbazones: cytotoxic activity in nanomolar doses against malignant gliomas JA Lessa, IC Mendes, PRO da Silva, MA Soares, RG dos Santos, ... European journal of medicinal chemistry 45 (12), 5671-5677, 2010 | 95 | 2010 |
Studies toward the structural optimization of new brazilizone-related trypanocidal 1, 3, 4-thiadiazole-2-arylhydrazone derivatives SA Carvalho, FAS Lopes, K Salomão, NC Romeiro, SMSV Wardell, ... Bioorganic & medicinal chemistry 16 (1), 413-421, 2008 | 61 | 2008 |
Novel 6-methanesulfonamide-3, 4-methylenedioxyphenyl-N-acylhydrazones: Orally effective anti-inflammatory drug candidates JLM Tributino, CD Duarte, RS Corrêa, AC Doriguetto, J Ellena, ... Bioorganic & medicinal chemistry 17 (3), 1125-1131, 2009 | 57 | 2009 |
CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (−)-spectaline NG Castro, RS Costa, LSB Pimentel, A Danuello, NC Romeiro, ... European Journal of Pharmacology 580 (3), 339-349, 2008 | 57 | 2008 |
Design, synthesis and pharmacological evaluation of HIV-1 reverse transcriptase inhibition of new indolin-2-ones N Boechat, WB Kover, V Bongertz, MM Bastos, NC Romeiro, ... Medicinal Chemistry 3 (6), 533-542, 2007 | 52 | 2007 |
Multi-target natural products as alternatives against oxidative stress in Chronic Obstructive Pulmonary Disease (COPD) PB Gonçalves, NC Romeiro European journal of medicinal chemistry 163, 911-931, 2019 | 49 | 2019 |
The effects of Roundup® in embryo development and energy metabolism of the zebrafish (Danio rerio) OS Panetto, HF Gomes, DSF Gomes, E Campos, NC Romeiro, EP Costa, ... Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology …, 2019 | 47 | 2019 |
In Vitro Anti-HMPV Activity of Meroditerpenoids from Marine Alga Stypopodium zonale (Dictyotales) G Mendes, AR Soares, L Sigiliano, F Machado, C Kaiser, N Romeiro, ... Molecules 16 (10), 8437-8450, 2011 | 43 | 2011 |
Construction of 4D-QSAR models for use in the design of novel p38-MAPK inhibitors NC Romeiro, MG Albuquerque, RB de Alencastro, M Ravi, AJ Hopfinger Journal of computer-aided molecular design 19, 385-400, 2005 | 42 | 2005 |
Design, synthesis, and biological evaluation of new 3-hydroxy-2-oxo-3-trifluoromethylindole as potential HIV-1 reverse transcriptase inhibitors N Boechat, WB Kover, MM Bastos, NC Romeiro, ASC Silva, FC Santos, ... Medicinal Chemistry Research 15, 492-510, 2007 | 38 | 2007 |
Structure-based design and biological profile of (E)-N-(4-Nitrobenzylidene)-2-naphthohydrazide, a novel small molecule inhibitor of IκB kinase-β CM Avila, AB Lopes, AS Gonçalves, LL da Silva, NC Romeiro, ... European journal of medicinal chemistry 46 (4), 1245-1253, 2011 | 32 | 2011 |
Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action JCS Costa, JS Neves, MVN de Souza, RA Siqueira, NC Romeiro, ... Bioorganic & medicinal chemistry letters 18 (3), 1162-1166, 2008 | 26 | 2008 |
Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer’s disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition … DC Santos, RR Henriques, MAAL Junior, AB Farias, ... Bioorganic & Medicinal Chemistry 28 (10), 115470, 2020 | 24 | 2020 |
Docking, synthesis and anti-diabetic activity of novel sulfonylhydrazone derivatives designed as PPAR-gamma agonists G Zapata-Sudo, L M Lima, S L Pereira, M M Trachez, F P da Costa, ... Current topics in medicinal chemistry 12 (19), 2037-2048, 2012 | 23 | 2012 |
Synthesis, pharmacological evaluation and docking studies of new sulindac analogues NC Romeiro, RDF Leite, LM Lima, SVS Cardozo, ALP de Miranda, ... European journal of medicinal chemistry 44 (5), 1959-1971, 2009 | 23 | 2009 |
Design, synthesis and activity against Trypanosoma cruzi of azaheterocyclic analogs of megazol AS Carvalho, RFS Menna-Barreto, NC Romeiro, SL De Castro, N Boechat Medicinal Chemistry 3 (5), 460-465, 2007 | 23 | 2007 |