Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease Nature 29 (375), 754-760, 1995 | 5530* | 1995 |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj, R Sims, ... Nature genetics 45 (12), 1452-1458, 2013 | 4404 | 2013 |
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease JC Lambert, S Heath, G Even, D Campion, K Sleegers, M Hiltunen, ... Nature genetics 41 (10), 1094-1099, 2009 | 2797 | 2009 |
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene EI Rogaev, R Sherrington, EA Rogaeva, G Levesque, M Ikeda, Y Liang, ... Nature 376 (6543), 775-778, 1995 | 2712 | 1995 |
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ... Nature genetics 51 (3), 414-430, 2019 | 2249 | 2019 |
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease P Hollingworth, D Harold, R Sims, A Gerrish, JC Lambert, ... Nature genetics 43 (5), 429-435, 2011 | 2187 | 2011 |
The genetic defect causing familial Alzheimer's disease maps on chromosome 21 PH St George-Hyslop, RE Tanzi, RJ Polinsky, JL Haines, L Nee, ... Science 235 (4791), 885-890, 1987 | 1633 | 1987 |
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease E Rogaeva, Y Meng, JH Lee, Y Gu, T Kawarai, F Zou, T Katayama, ... Nature genetics 39 (2), 168-177, 2007 | 1406 | 2007 |
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing G Yu, M Nishimura, S Arawaka, D Levitan, L Zhang, A Tandon, YQ Song, ... Nature 407 (6800), 48-54, 2000 | 1288 | 2000 |
Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders PH Lee, V Anttila, H Won, YCA Feng, J Rosenthal, Z Zhu, EM Tucker-Drob, ... Cell 179 (7), 1469-1482. e11, 2019 | 1059 | 2019 |
Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years MP Amato, G Ponziani, G Siracusa, S Sorbi Archives of neurology 58 (10), 1602-1606, 2001 | 973 | 2001 |
New insights into the genetic etiology of Alzheimer’s disease and related dementias C Bellenguez, F Küçükali, IE Jansen, L Kleineidam, S Moreno-Grau, ... Nature genetics 54 (4), 412-436, 2022 | 972 | 2022 |
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease R Sims, SJ Van Der Lee, AC Naj, C Bellenguez, N Badarinarayan, ... Nature genetics 49 (9), 1373-1384, 2017 | 920 | 2017 |
Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias L Mosconi, WH Tsui, K Herholz, A Pupi, A Drzezga, G Lucignani, ... Journal of nuclear medicine 49 (3), 390-398, 2008 | 859 | 2008 |
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa HJ Watson, Z Yilmaz, LM Thornton, C Hübel, JRI Coleman, HA Gaspar, ... Nature genetics 51 (8), 1207-1214, 2019 | 826 | 2019 |
EFNS guidelines for the diagnosis and management of Alzheimer’s disease J Hort, JT O’Brien, G Gainotti, T Pirttila, BO Popescu, I Rektorová, S Sorbi, ... European Journal of Neurology 17 (10), 1236-1248, 2010 | 783 | 2010 |
APOE and Alzheimer disease: a major gene with semi-dominant inheritance E Genin, D Hannequin, D Wallon, K Sleegers, M Hiltunen, O Combarros, ... Molecular psychiatry 16 (9), 903-907, 2011 | 773 | 2011 |
Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14 P St George-Hyslop, J Haines, EI Rogaev, M Mortilla, G Vaula, ... Nature genetics 2 (4), 330-334, 1992 | 653 | 1992 |
Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis JD Rohrer, JM Nicholas, DM Cash, J Van Swieten, E Dopper, L Jiskoot, ... The Lancet Neurology 14 (3), 253-262, 2015 | 560 | 2015 |
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder PH St George-Hyslop, JL Haines, LA Farrer, R Polinsky, CV Broeckhoven, ... Nature 347 (6289), 194-197, 1990 | 512 | 1990 |