Distinct immune cell populations define response to anti-PD-1 monotherapy and anti-PD-1/anti-CTLA-4 combined therapy TN Gide, C Quek, AM Menzies, AT Tasker, P Shang, J Holst, J Madore, ... Cancer cell 35 (2), 238-255. e6, 2019 | 662 | 2019 |
ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer M Van Geldermalsen, Q Wang, R Nagarajah, AD Marshall, A Thoeng, ... Oncogene 35 (24), 3201-3208, 2016 | 555 | 2016 |
Orchestrated intron retention regulates normal granulocyte differentiation JJL Wong, W Ritchie, OA Ebner, M Selbach, JWH Wong, Y Huang, D Gao, ... Cell 154 (3), 583-595, 2013 | 475 | 2013 |
Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration S Balaban, RF Shearer, LS Lee, M van Geldermalsen, M Schreuder, ... Cancer & metabolism 5, 1-14, 2017 | 357 | 2017 |
Targeting ASCT2‐mediated glutamine uptake blocks prostate cancer growth and tumour development Q Wang, RA Hardie, AJ Hoy, M Van Geldermalsen, D Gao, L Fazli, ... The Journal of pathology 236 (3), 278-289, 2015 | 352 | 2015 |
Generation of T-cell receptor retrogenic mice J Holst, AL Szymczak-Workman, KM Vignali, AR Burton, CJ Workman, ... Nature protocols 1 (1), 406-417, 2006 | 321 | 2006 |
L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia Q Wang, J Holst American journal of cancer research 5 (4), 1281, 2015 | 310 | 2015 |
Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells J Holst, S Watson, MS Lord, SS Eamegdool, DV Bax, LB Nivison-Smith, ... Nature biotechnology 28 (10), 1123-1128, 2010 | 306 | 2010 |
General nature of the STAT3-activated anti-inflammatory response KC El Kasmi, J Holst, M Coffre, L Mielke, A De Pauw, N Lhocine, ... The Journal of Immunology 177 (11), 7880-7888, 2006 | 268 | 2006 |
Targeting glutamine transport to suppress melanoma cell growth Q Wang, KA Beaumont, NJ Otte, J Font, CG Bailey, M van Geldermalsen, ... International journal of cancer 135 (5), 1060-1071, 2014 | 239 | 2014 |
Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development Q Wang, J Tiffen, CG Bailey, ML Lehman, W Ritchie, L Fazli, C Metierre, ... Journal of the National Cancer Institute 105 (19), 1463-1473, 2013 | 220 | 2013 |
Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans RJ Taft, C Simons, S Nahkuri, H Oey, DJ Korbie, TR Mercer, J Holst, ... Nature structural & molecular biology 17 (8), 1030-1034, 2010 | 200 | 2010 |
Rapid analysis of T-cell selection in vivo using T cell–receptor retrogenic mice J Holst, KM Vignali, AR Burton, DAA Vignali Nature methods 3 (3), 191-197, 2006 | 192 | 2006 |
Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression Q Wang, CG Bailey, C Ng, J Tiffen, A Thoeng, V Minhas, ML Lehman, ... Cancer research 71 (24), 7525-7536, 2011 | 190 | 2011 |
Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity J Holst, H Wang, KD Eder, CJ Workman, KL Boyd, Z Baquet, H Singh, ... Nature immunology 9 (6), 658-666, 2008 | 173 | 2008 |
Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia S Flamant, W Ritchie, J Guilhot, J Holst, ML Bonnet, JC Chomel, F Guilhot, ... Haematologica 95 (8), 1325, 2010 | 143 | 2010 |
Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo JC Tiffen, CG Bailey, C Ng, JEJ Rasko, J Holst Molecular cancer 9, 1-8, 2010 | 127 | 2010 |
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis ZD Nassar, CY Mah, J Dehairs, IJG Burvenich, S Irani, MM Centenera, ... Elife 9, e54166, 2020 | 122 | 2020 |
Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment JJL Wong, D Gao, TV Nguyen, CT Kwok, M van Geldermalsen, ... Nature communications 8 (1), 15134, 2017 | 112 | 2017 |
p27Kip1 signaling: Transcriptional and post-translational regulation SST Hnit, C Xie, M Yao, J Holst, A Bensoussan, P De Souza, Z Li, Q Dong The international journal of biochemistry & cell biology 68, 9-14, 2015 | 111 | 2015 |