Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation H Huang, H Weng, W Sun, X Qin, H Shi, H Wu, BS Zhao, A Mesquita, ... Nature cell biology 20 (3), 285-295, 2018 | 2040 | 2018 |
R-2HG exhibits anti-tumor activity by targeting FTO/m6A/MYC/CEBPA signaling R Su, L Dong, C Li, S Nachtergaele, M Wunderlich, Y Qing, X Deng, ... Cell 172 (1), 90-105. e23, 2018 | 884 | 2018 |
METTL14 inhibits hematopoietic stem/progenitor differentiation and promotes leukemogenesis via mRNA m6A modification H Weng, H Huang, H Wu, X Qin, BS Zhao, L Dong, H Shi, J Skibbe, ... Cell stem cell 22 (2), 191-205. e9, 2018 | 832 | 2018 |
RNA N6-methyladenosine modification in cancers: current status and perspectives X Deng, R Su, H Weng, H Huang, Z Li, J Chen Cell research 28 (5), 507-517, 2018 | 612 | 2018 |
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally H Huang, H Weng, K Zhou, T Wu, BS Zhao, M Sun, Z Chen, X Deng, ... Nature 567 (7748), 414-419, 2019 | 512 | 2019 |
Targeting FTO suppresses cancer stem cell maintenance and immune evasion R Su, L Dong, Y Li, M Gao, L Han, M Wunderlich, X Deng, H Li, Y Huang, ... Cancer cell 38 (1), 79-96. e11, 2020 | 473 | 2020 |
RNA demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia C Shen, Y Sheng, AC Zhu, S Robinson, X Jiang, L Dong, H Chen, R Su, ... Cell stem cell 27 (1), 64-80. e9, 2020 | 279 | 2020 |
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis Y Qing, L Dong, L Gao, C Li, Y Li, L Han, E Prince, B Tan, X Deng, ... Molecular cell 81 (5), 922-939. e9, 2021 | 202 | 2021 |
Role of N6-methyladenosine modification in cancer X Deng, R Su, X Feng, M Wei, J Chen Current opinion in genetics & development 48, 1-7, 2018 | 197 | 2018 |
METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis R Su, L Dong, Y Li, M Gao, PC He, W Liu, J Wei, Z Zhao, L Gao, L Han, ... Nature cell biology 24 (2), 205-216, 2022 | 173 | 2022 |
Critical enzymatic functions of FTO in obesity and cancer X Deng, R Su, S Stanford, J Chen Frontiers in endocrinology 9, 396, 2018 | 120 | 2018 |
Cancer precision medicine: from cancer screening to drug selection and personalized immunotherapy X Deng, Y Nakamura Trends in pharmacological sciences 38 (1), 15-24, 2017 | 92 | 2017 |
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia H Weng, F Huang, Z Yu, Z Chen, E Prince, Y Kang, K Zhou, W Li, J Hu, ... Cancer Cell 40 (12), 1566-1582. e10, 2022 | 91 | 2022 |
FTO in cancer: functions, molecular mechanisms, and therapeutic implications Y Li, R Su, X Deng, Y Chen, J Chen Trends in cancer 8 (7), 598-614, 2022 | 86 | 2022 |
RNA modifications in cancer: functions, mechanisms, and therapeutic implications H Huang, H Weng, X Deng, J Chen Annual Review of Cancer Biology 4, 221-240, 2020 | 72 | 2020 |
The roles and implications of RNA m6A modification in cancer X Deng, Y Qing, D Horne, H Huang, J Chen Nature Reviews Clinical Oncology 20 (8), 507-526, 2023 | 65 | 2023 |
Impact of temperature exposure on stability of drugs in a real-world out-of-hospital setting S De Winter, P Vanbrabant, NTT Vi, X Deng, I Spriet, A Van Schepdael, ... Annals of emergency medicine 62 (4), 380-387. e1, 2013 | 60 | 2013 |
Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC C Li, L Dong, R Su, Y Bi, Y Qing, X Deng, Y Zhou, C Hu, M Yu, H Huang, ... haematologica 105 (1), 148, 2020 | 50 | 2020 |
Hypoxia‐inducible factor‐2α directly promotes BCRP expression and mediates the resistance of ovarian cancer stem cells to adriamycin M He, H Wu, Q Jiang, Y Liu, L Han, Y Yan, B Wei, F Liu, X Deng, H Chen, ... Molecular oncology 13 (2), 403-421, 2019 | 47 | 2019 |
Effects of SMYD 2‐mediated EML 4‐ALK methylation on the signaling pathway and growth in non‐small‐cell lung cancer cells R Wang, X Deng, Y Yoshioka, T Vougiouklakis, JH Park, T Suzuki, ... Cancer Science 108 (6), 1203-1209, 2017 | 47 | 2017 |