Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery H Lee, AKR Lytton-Jean, Y Chen, KT Love, AI Park, ED Karagiannis, ... Nature nanotechnology 7 (6), 389-393, 2012 | 1211 | 2012 |
Lipid-like materials for low-dose, in vivo gene silencing KT Love, KP Mahon, CG Levins, KA Whitehead, W Querbes, JR Dorkin, ... Proceedings of the National Academy of Sciences 107 (5), 1864-1869, 2010 | 1093 | 2010 |
Therapeutic siRNA silencing in inflammatory monocytes in mice F Leuschner, P Dutta, R Gorbatov, TI Novobrantseva, JS Donahoe, ... Nature biotechnology 29 (11), 1005-1010, 2011 | 874 | 2011 |
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling G Sahay, W Querbes, C Alabi, A Eltoukhy, S Sarkar, C Zurenko, ... Nature biotechnology 31 (7), 653-658, 2013 | 849 | 2013 |
Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation D Chen, KT Love, Y Chen, AA Eltoukhy, C Kastrup, G Sahay, A Jeon, ... Journal of the American Chemical Society 134 (16), 6948-6951, 2012 | 517 | 2012 |
Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates Y Dong, KT Love, JR Dorkin, S Sirirungruang, Y Zhang, D Chen, ... Proceedings of the National Academy of Sciences 111 (11), 3955-3960, 2014 | 506 | 2014 |
Gold, poly (β-amino ester) nanoparticles for small interfering RNA delivery JS Lee, JJ Green, KT Love, J Sunshine, R Langer, DG Anderson Nano letters 9 (6), 2402-2406, 2009 | 346 | 2009 |
BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition R Haq, S Yokoyama, EB Hawryluk, GB Jönsson, DT Frederick, K McHenry, ... Proceedings of the National Academy of Sciences 110 (11), 4321-4326, 2013 | 277 | 2013 |
Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery DJ Siegwart, KA Whitehead, L Nuhn, G Sahay, H Cheng, S Jiang, M Ma, ... Proceedings of the National Academy of Sciences 108 (32), 12996-13001, 2011 | 267 | 2011 |
Lipidoid-coated iron oxide nanoparticles for efficient DNA and siRNA delivery S Jiang, AA Eltoukhy, KT Love, R Langer, DG Anderson Nano letters 13 (3), 1059-1064, 2013 | 266 | 2013 |
Aminoalcohol lipidoids and uses thereof KP Mahon, KT Love, CG Levins, KA Whitehead, RS Langer, DG Anderson US Patent 8,450,298, 2013 | 204 | 2013 |
Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery CA Alabi, KT Love, G Sahay, H Yin, KM Luly, R Langer, DG Anderson Proceedings of the National Academy of Sciences 110 (32), 12881-12886, 2013 | 182 | 2013 |
Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis YH Huang, Y Bao, W Peng, M Goldberg, K Love, DA Bumcrot, G Cole, ... Proceedings of the National Academy of Sciences 106 (9), 3426-3430, 2009 | 175 | 2009 |
Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system F DeRosa, B Guild, S Karve, L Smith, K Love, JR Dorkin, KJ Kauffman, ... Gene therapy 23 (10), 699-707, 2016 | 165 | 2016 |
Aminoalcohol lipidoids and uses thereof KP Mahon, KT Love, CG Levins, KA Whitehead, RS Langer, DG Anderson US Patent 8,969,353, 2015 | 145 | 2015 |
Systemic RNAi-mediated gene silencing in nonhuman primate and rodent myeloid cells TI Novobrantseva, A Borodovsky, J Wong, B Klebanov, M Zafari, K Yucius, ... Molecular Therapy-Nucleic Acids 1, 2012 | 139 | 2012 |
Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery DN Nguyen, KP Mahon, G Chikh, P Kim, H Chung, AP Vicari, KT Love, ... Proceedings of the National Academy of Sciences 109 (14), E797-E803, 2012 | 127 | 2012 |
Amino acid-, peptide-and polypeptide-lipids, isomers, compositions, and uses thereof Y Dong, KT Love, RS Langer, DG Anderson, D Chen, Y Chen, AJ Vegas, ... US Patent 9,512,073, 2016 | 118 | 2016 |
Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery KP Mahon, KT Love, KA Whitehead, J Qin, A Akinc, E Leshchiner, ... Bioconjugate chemistry 21 (8), 1448-1454, 2010 | 96 | 2010 |
Synergistic silencing: combinations of lipid-like materials for efficacious siRNA delivery KA Whitehead, G Sahay, GZ Li, KT Love, CA Alabi, M Ma, C Zurenko, ... Molecular Therapy 19 (9), 1688-1694, 2011 | 81 | 2011 |