Selective expansion of high-or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. MA Alexander-Miller, GR Leggatt, JA Berzofsky Proceedings of the National Academy of Sciences 93 (9), 4102-4107, 1996 | 653 | 1996 |
Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity P Bhat, G Leggatt, N Waterhouse, IH Frazer Cell death & disease 8 (6), e2836-e2836, 2017 | 479 | 2017 |
Role of intratumoural heterogeneity in cancer drug resistance: molecular and clinical perspectives NA Saunders, F Simpson, EW Thompson, MM Hill, L Endo‐Munoz, ... EMBO molecular medicine 4 (8), 675-684, 2012 | 305 | 2012 |
Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL. MA Alexander-Miller, GR Leggatt, A Sarin, JA Berzofsky The Journal of experimental medicine 184 (2), 485-492, 1996 | 279 | 1996 |
Antigen-specific CD4+ T-cell help is required to activate a memory CD8+ T cell to a fully functional tumor killer cell FG Gao, V Khammanivong, WJ Liu, GR Leggatt, IH Frazer, GJP Fernando Cancer research 62 (22), 6438-6441, 2002 | 208 | 2002 |
Potential strategies utilised by papillomavirus to evade host immunity IH Frazer, R Thomas, J Zhou, GR Leggatt, L Dunn, N McMillan, RW Tindle, ... Immunological reviews 168 (1), 131-142, 1999 | 168 | 1999 |
RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin LN Putral, MJ Bywater, W Gu, NA Saunders, BG Gabrielli, GR Leggatt, ... Molecular pharmacology 68 (5), 1311-1319, 2005 | 162 | 2005 |
Inhibition of cervical cancer cell growth in vitro and in vivo with lentiviral-vector delivered short hairpin RNA targeting human papillomavirus E6 and E7 oncogenes W Gu, L Putral, K Hengst, K Minto, NA Saunders, G Leggatt, NAJ McMillan Cancer gene therapy 13 (11), 1023-1032, 2006 | 161 | 2006 |
The role of CXCR3 and its chemokine ligands in skin disease and cancer PT Kuo, Z Zeng, N Salim, S Mattarollo, JW Wells, GR Leggatt Frontiers in medicine 5, 271, 2018 | 157 | 2018 |
Prevention and treatment of papillomavirus-related cancers through immunization IH Frazer, GR Leggatt, SR Mattarollo Annual review of immunology 29 (1), 111-138, 2011 | 141 | 2011 |
Serological evaluation of the 12 kDa subunit of antigen B in Echinococcus granulosus cyst fluid by immunoblot analysis GR Leggatt, W Yang, DP McManus Transactions of the Royal Society of Tropical Medicine and Hygiene 86 (2 …, 1992 | 120 | 1992 |
Polynucleotide viral vaccines: codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacy WJ Liu, KN Zhao, FG Gao, GR Leggatt, GJP Fernando, IH Frazer Vaccine 20 (5-6), 862-869, 2001 | 114 | 2001 |
Regulation of immune responses to HPVinfection and during HPV‐directed immunotherapy P Bhat, SR Mattarollo, C Gosmann, IH Frazer, GR Leggatt Immunological reviews 239 (1), 85-98, 2011 | 98 | 2011 |
Papillomavirus virus-like particles for the delivery of multiple cytotoxic T cell epitopes WJ Liu, XS Liu, KN Zhao, GR Leggatt, IH Frazer Virology 273 (2), 374-382, 2000 | 96 | 2000 |
Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment T Kobayashi, PY Lam, H Jiang, K Bednarska, R Gloury, V Murigneux, ... Blood, The Journal of the American Society of Hematology 136 (26), 3004-3017, 2020 | 94 | 2020 |
Chimeric human papilloma virus–simian/human immunodeficiency virus virus-like-particle vaccines: immunogenicity and protective efficacy in macaques CJ Dale, XS Liu, R De Rose, DFJ Purcell, J Anderson, Y Xu, GR Leggatt, ... Virology 301 (1), 176-187, 2002 | 84 | 2002 |
Impaired antigen presentation and effectiveness of combined active/passive immunotherapy for epithelial tumors K Matsumoto, GR Leggatt, J Zhong, X Liu, RL de Kluyver, T Peters, ... Journal of the National Cancer Institute 96 (21), 1611-1619, 2004 | 79 | 2004 |
IL-10 mediates suppression of the CD8 T cell IFN-γ response to a novel viral epitope in a primed host XS Liu, Y Xu, L Hardy, V Khammanivong, W Zhao, GJP Fernando, ... The Journal of Immunology 171 (9), 4765-4772, 2003 | 72 | 2003 |
Tolerance or immunity to a tumor antigen expressed in somatic cells can be determined by systemic proinflammatory signals at the time of first antigen exposure IH Frazer, RD Kluyver, GR Leggatt, H Yang Guo, L Dunn, O White, ... The Journal of Immunology 167 (11), 6180-6187, 2001 | 69 | 2001 |
HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2-and CCL5-mediated recruitment of mast cells AS Bergot, N Ford, GR Leggatt, JW Wells, IH Frazer, MA Grimbaldeston PLoS pathogens 10 (10), e1004466, 2014 | 68 | 2014 |