| Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial W Hueber, BE Sands, S Lewitzky, M Vandemeulebroecke, W Reinisch, ... Gut 61 (12), 1693-1700, 2012 | 1619 | 2012 |
| Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis W Hueber, DD Patel, T Dryja, AM Wright, I Koroleva, G Bruin, C Antoni, ... Science translational medicine 2 (52), 52ra72-52ra72, 2010 | 1105 | 2010 |
| Integrated capillary electrophoresis on flexible silicone microdevices: analysis of DNA restriction fragments and detection of single DNA molecules on microchips CS Effenhauser, GJM Bruin, A Paulus, M Ehrat Analytical Chemistry 69 (17), 3451-3457, 1997 | 1017 | 1997 |
| Recent developments in electrokinetically driven analysis on microfabricated devices GJM Bruin ELECTROPHORESIS: An International Journal 21 (18), 3931-3951, 2000 | 476 | 2000 |
| Integrated chip‐based capillary electrophoresis CS Effenhauser, GJM Bruin, A Paulus Electrophoresis 18 (12‐13), 2203-2213, 1997 | 388 | 1997 |
| Capillary zone electrophoretic separations of proteins in polyethylene glycol-modified capillaries GJM Bruin, JP Chang, RH Kuhlman, K Zegers, JC Kraak, H Poppe Journal of Chromatography A 471, 429-436, 1989 | 351 | 1989 |
| β-Defensin 2 is a responsive biomarker of IL-17A–driven skin pathology in patients with psoriasis F Kolbinger, C Loesche, MA Valentin, X Jiang, Y Cheng, P Jarvis, ... Journal of Allergy and Clinical Immunology 139 (3), 923-932. e8, 2017 | 238 | 2017 |
| Secukinumab in Crohn’s Disease Study Group. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn’s disease: unexpected results of a randomised … W Hueber, BE Sands, S Lewitzky, M Vandemeulebroecke, W Reinisch, ... Gut 61 (12), 1693-1700, 2012 | 192 | 2012 |
| Performance of carbohydrate-modified fused-silica capillaries for the separation of proteins by zone electrophoresis GJM Bruin, R Huisden, JC Kraak, H Poppe Journal of Chromatography A 480, 339-349, 1989 | 169 | 1989 |
| Electrically driven open-tubular liquid chromatography GJM Bruin, PPH Tock, JC Kraak, H Poppe Journal of Chromatography A 517, 557-572, 1990 | 126 | 1990 |
| Theoretical and experimental aspects of indirect detection in capillary electrophoresis GJM Bruin, AC van Asten, X Xu, H Poppe Journal of Chromatography A 608 (1-2), 97-107, 1992 | 119 | 1992 |
| Pharmacokinetics, metabolism, and disposition of deferasirox in β-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state F Waldmeier, GJ Bruin, U Glaenzel, K Hazell, R Sechaud, S Warrington, ... Drug Metabolism and Disposition 38 (5), 808-816, 2010 | 109 | 2010 |
| Optimization and evaluation of the performance of arrangements for UV detection in high-resolution separations using fused-silica capillaries GJM Bruin, G Stegeman, AC Van Asten, X Xu, JC Kraak, H Poppe Journal of Chromatography A 559 (1-2), 163-181, 1991 | 108 | 1991 |
| Fritless capillary electrochromatography M Mayer, E Rapp, C Marck, GJM Bruin ELECTROPHORESIS: An International Journal 20 (1), 43-49, 1999 | 101 | 1999 |
| Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats GJM Bruin, T Faller, H Wiegand, A Schweitzer, H Nick, J Schneider, ... Drug metabolism and disposition 36 (12), 2523-2538, 2008 | 92 | 2008 |
| Hologram-based refractive index detector for capillary electrophoresis: separation of metal ions B Krattiger, GJM Bruin, AE Bruno Analytical Chemistry 66 (1), 1-8, 1994 | 84 | 1994 |
| Secukinumab, a fully human anti‐interleukin‐17A monoclonal antibody, exhibits minimal immunogenicity in patients with moderate‐to‐severe plaque psoriasis K Reich, A Blauvelt, A Armstrong, RG Langley, T Fox, J Huang, ... British Journal of Dermatology 176 (3), 752-758, 2017 | 83 | 2017 |
| Population pharmacokinetic modeling of secukinumab in patients with moderate to severe psoriasis G Bruin, C Loesche, J Nyirady, O Sander The Journal of Clinical Pharmacology 57 (7), 876-885, 2017 | 70 | 2017 |
| Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion. C Dragatin, F Polus, M Bodenlenz, C Calonder, B Aigner, KI Tiffner, ... Experimental dermatology 25 (2), 2016 | 54 | 2016 |
| ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans MR John, L Widler, R Gamse, T Buhl, K Seuwen, W Breitenstein, ... Bone 49 (2), 233-241, 2011 | 47 | 2011 |
