Cytoplasmic chromatin triggers inflammation in senescence and cancer Z Dou, K Ghosh, MG Vizioli, J Zhu, P Sen, KJ Wangensteen, J Simithy, ... Nature 550 (7676), 402-406, 2017 | 1080 | 2017 |
Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease R Nativio, G Donahue, A Berson, Y Lan, A Amlie-Wolf, F Tuzer, JB Toledo, ... Nature neuroscience 21 (4), 497-505, 2018 | 301 | 2018 |
An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease R Nativio, Y Lan, G Donahue, S Sidoli, A Berson, AR Srinivasan, ... Nature genetics 52 (10), 1024-1035, 2020 | 250 | 2020 |
Using the RDP classifier to predict taxonomic novelty and reduce the search space for finding novel organisms Y Lan, Q Wang, JR Cole, GL Rosen PLoS one 7 (3), e32491, 2012 | 216 | 2012 |
Chromatin structure dynamics during the mitosis-to-G1 phase transition H Zhang, DJ Emerson, TG Gilgenast, KR Titus, Y Lan, P Huang, D Zhang, ... Nature 576 (7785), 158-162, 2019 | 184 | 2019 |
β-Hydroxybutyrate suppresses colorectal cancer O Dmitrieva-Posocco, AC Wong, P Lundgren, AM Golos, HC Descamps, ... Nature 605 (7908), 160-165, 2022 | 174 | 2022 |
Herbivorous turtle ants obtain essential nutrients from a conserved nitrogen-recycling gut microbiome Y Hu, JG Sanders, P Łukasik, CL D’Amelio, JS Millar, DR Vann, Y Lan, ... Nature communications 9 (1), 1-14, 2018 | 163 | 2018 |
Metazoan nuclear pores provide a scaffold for poised genes and mediate induced enhancer-promoter contacts P Pascual-Garcia, B Debo, JR Aleman, JA Talamas, Y Lan, NH Nguyen, ... Molecular cell 66 (1), 63-76. e6, 2017 | 136 | 2017 |
Histone acetyltransferase p300 induces de novo super-enhancers to drive cellular senescence P Sen, Y Lan, CY Li, S Sidoli, G Donahue, Z Dou, B Frederick, Q Chen, ... Molecular cell 73 (4), 684-698. e8, 2019 | 112 | 2019 |
Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes JM Luppino, DS Park, SC Nguyen, Y Lan, Z Xu, R Yunker, EF Joyce Nature genetics 52 (8), 840-848, 2020 | 101 | 2020 |
High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening RA Gier, KA Budinich, NH Evitt, Z Cao, ES Freilich, Q Chen, J Qi, Y Lan, ... Nature communications 11 (1), 3455, 2020 | 98 | 2020 |
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry J Kee, S Thudium, DM Renner, K Glastad, K Palozola, Z Zhang, Y Li, ... Nature 610 (7931), 381-388, 2022 | 92 | 2022 |
Marker genes that are less conserved in their sequences are useful for predicting genome-wide similarity levels between closely related prokaryotic strains Y Lan, G Rosen, R Hershberg Microbiome 4, 1-13, 2016 | 90 | 2016 |
The NIEHS TaRGET II Consortium and environmental epigenomics T Wang, EC Pehrsson, D Purushotham, D Li, X Zhuo, B Zhang, ... Nature biotechnology 36 (3), 225-227, 2018 | 88 | 2018 |
KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis E Lin-Shiao, Y Lan, M Coradin, A Anderson, G Donahue, CL Simpson, ... Genes & development 32 (2), 181-193, 2018 | 87 | 2018 |
Core components of the nuclear pore bind distinct states of chromatin and contribute to polycomb repression A Gozalo, A Duke, Y Lan, P Pascual-Garcia, JA Talamas, SC Nguyen, ... Molecular Cell 77 (1), 67-81. e7, 2020 | 77 | 2020 |
ZNF410 uniquely activates the NuRD component CHD4 to silence fetal hemoglobin expression X Lan, R Ren, R Feng, LC Ly, Y Lan, Z Zhang, N Aboreden, K Qin, ... Molecular cell 81 (2), 239-254. e8, 2021 | 63 | 2021 |
Distinct properties and functions of CTCF revealed by a rapidly inducible degron system J Luan, G Xiang, PA Gómez-García, JM Tome, Z Zhang, MW Vermunt, ... Cell reports 34 (8), 2021 | 61 | 2021 |
LSD1 inhibition promotes epithelial differentiation through derepression of fate-determining transcription factors S Egolf, Y Aubert, M Doepner, A Anderson, A Maldonado-Lopez, ... Cell reports 28 (8), 1981-1992. e7, 2019 | 61 | 2019 |
Selecting age-related functional characteristics in the human gut microbiome Y Lan, A Kriete, GL Rosen Microbiome 1, 1-12, 2013 | 61 | 2013 |