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Sebastian Gergel
Sebastian Gergel
Lead Research Scientist at EnginZyme
在 enginzyme.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Asymmetric enzymatic hydration of unactivated, aliphatic alkenes
RM Demming, SC Hammer, BM Nestl, S Gergel, S Fademrecht, J Pleiss, ...
Angewandte Chemie 131 (1), 179-183, 2019
622019
Biocatalytic access to piperazines from diamines and dicarbonyls
N Borlinghaus, S Gergel, BM Nestl
ACS Catalysis 8 (4), 3727-3732, 2018
422018
Enzymatic control over reactive intermediates enables direct oxidation of alkenes to carbonyls by a P450 iron-oxo species
J Soler, S Gergel, C Klaus, SC Hammer, M Garcia-Borràs
Journal of the American Chemical Society 144 (35), 15954-15968, 2022
372022
Substrate Profiling of Anion Methyltransferases for Promiscuous Synthesis of S‐Adenosylmethionine Analogs from Haloalkanes
KH Schülke, F Ospina, K Hörnschemeyer, S Gergel, SC Hammer
ChemBioChem 23 (4), e202100632, 2022
272022
Engineered cytochrome P450 for direct arylalkene-to-ketone oxidation via highly reactive carbocation intermediates
S Gergel, J Soler, A Klein, KH Schülke, B Hauer, M Garcia-Borràs, ...
Nature Catalysis 6 (7), 606-617, 2023
202023
Methylation of unactivated alkenes with engineered methyltransferases to generate non‐natural terpenoids
B Aberle, D Kowalczyk, S Massini, AN Egler‐Kemmerer, S Gergel, ...
Angewandte Chemie International Edition 62 (26), e202301601, 2023
112023
Directed evolution of a ketone synthase for efficient and highly selective functionalization of internal alkenes by accessing reactive carbocation intermediates
S Gergel, J Soler, A Klein, K Schülke, B Hauer, M Garcia-Borràs, ...
62022
Molecular Basis for Chemoselectivity Control in Oxidations of Internal Aryl‐Alkenes Catalyzed by Laboratory Evolved P450s
J Soler, S Gergel, SC Hammer, M Garcia‐Borràs
ChemBioChem 25 (10), e202400066, 2024
12024
Molecular Basis for Chemoselectivity Control in Oxidations of Internal Aryl-Alkenes Catalyzed by Laboratory Evolved P450s
J Soler i Parpal, S Gergel, SC Hammer, M Garcia Borràs
ChemBioChem, 2024, vol. 25, núm. 10, p. e202400066, 2024
2024
Cover Picture: Methylation of Unactivated Alkenes with Engineered Methyltransferases To Generate Non‐natural Terpenoids (Angew. Chem. Int. Ed. 26/2023)
B Aberle, D Kowalczyk, S Massini, AN Egler‐Kemmerer, S Gergel, ...
Angewandte Chemie International Edition 62 (26), e202306111, 2023
2023
Methylierung nicht‐aktivierter Alkene mit modifizierten Methyltransferasen zur Diversifizierung von Terpenoiden
B Aberle, D Kowalczyk, S Massini, AN Egler‐Kemmerer, S Gergel, ...
Angewandte Chemie 135 (26), e202301601, 2023
2023
Gerichtete Evolution und mechanistische Studien von carbonylselektiven Alken-Oxygenasen und deren Anwendung in der asymmetrischen Synthese
S Gergel
Dissertation, Bielefeld, Universität Bielefeld, 2021, 2021
2021
3.5 Preparation of Imine Reductases at 15 L Scale and Their Application in Asymmetric Piperazine Synthesis
N Borlinghaus, S Gergel, BM Nestl, F Thol, H Penders
Applied Biocatalysis: The Chemist's Enzyme Toolbox, 156, 2020
2020
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