| Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin Y Saitoh, H Suzuki, K Tani, K Nishikawa, K Irie, Y Ogura, A Tamura, ... Science 347 (6223), 775-778, 2015 | 216 | 2015 |
| Crystal structures of the gastric proton pump K Abe, K Irie, H Nakanishi, H Suzuki, Y Fujiyoshi Nature 556 (7700), 214-218, 2018 | 107 | 2018 |
| Control of Spontaneous Ca2+ Transients Is Critical for Neuronal Maturation in the Developing Neocortex Y Bando, K Irie, T Shimomura, H Umeshima, Y Kushida, M Kengaku, ... Cerebral Cortex 26 (1), 106-117, 2016 | 89 | 2016 |
| Comparative study of the gating motif and C-type inactivation in prokaryotic voltage-gated sodium channels K Irie, K Kitagawa, H Nagura, T Imai, T Shimomura, Y Fujiyoshi Journal of biological chemistry 285 (6), 3685-3694, 2010 | 82 | 2010 |
| Two alternative conformations of a voltage-gated sodium channel CJ Tsai, K Tani, K Irie, Y Hiroaki, T Shimomura, DG McMillan, GM Cook, ... Journal of molecular biology 425 (22), 4074-4088, 2013 | 70 | 2013 |
| Morphologic determinant of tight junctions revealed by claudin-3 structures S Nakamura, K Irie, H Tanaka, K Nishikawa, H Suzuki, Y Saitoh, ... Nature communications 10 (1), 816, 2019 | 64 | 2019 |
| Crystal structure of a human plasma membrane phospholipid flippase H Nakanishi, K Irie, K Segawa, K Hasegawa, Y Fujiyoshi, S Nagata, ... Journal of Biological Chemistry 295 (30), 10180-10194, 2020 | 49 | 2020 |
| Development of novel AKR1C3 inhibitors as new potential treatment for castration-resistant prostate cancer S Endo, H Oguri, J Segawa, M Kawai, D Hu, S Xia, T Okada, K Irie, S Fujii, ... Journal of medicinal chemistry 63 (18), 10396-10411, 2020 | 36 | 2020 |
| Crystal structure of the Homer 1 family conserved region reveals the interaction between the EVH1 domain and own proline-rich motif K Irie, T Nakatsu, K Mitsuoka, A Miyazawa, K Sobue, Y Hiroaki, T Doi, ... Journal of molecular biology 318 (4), 1117-1126, 2002 | 35 | 2002 |
| The C-terminal helical bundle of the tetrameric prokaryotic sodium channel accelerates the inactivation rate K Irie, T Shimomura, Y Fujiyoshi Nature communications 3 (1), 793, 2012 | 33 | 2012 |
| A native prokaryotic voltage-dependent calcium channel with a novel selectivity filter sequence T Shimomura, Y Yonekawa, H Nagura, M Tateyama, Y Fujiyoshi, K Irie Elife 9, e52828, 2020 | 28 | 2020 |
| A single K+-binding site in the crystal structure of the gastric proton pump K Yamamoto, V Dubey, K Irie, H Nakanishi, H Khandelia, Y Fujiyoshi, ... Elife 8, e47701, 2019 | 22 | 2019 |
| Arrangement and mobility of the voltage sensor domain in prokaryotic voltage-gated sodium channels T Shimomura, K Irie, H Nagura, T Imai, Y Fujiyoshi Journal of biological chemistry 286 (9), 7409-7417, 2011 | 19 | 2011 |
| Optimized expression and purification of NavAb provide the structural insight into the voltage dependence K Irie, Y Haga, T Shimomura, Y Fujiyoshi FEBS letters 592 (2), 274-283, 2018 | 18 | 2018 |
| Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations K Abe, K Yamamoto, K Irie, T Nishizawa, A Oshima Nature Communications 12 (1), 5709, 2021 | 7 | 2021 |
| Molecular determinants of prokaryotic voltage‐gated sodium channels for recognition of local anesthetics T Shimomura, K Irie, Y Fujiyoshi The FEBS Journal 283 (15), 2881-2895, 2016 | 7 | 2016 |
| Evidence for lateral mobility of voltage sensors in prokaryotic voltage-gated sodium channels H Nagura, K Irie, T Imai, T Shimomura, T Hige, Y Fujiyoshi Biochemical and biophysical research communications 399 (3), 341-346, 2010 | 7 | 2010 |
| Recognition mechanism of a novel gabapentinoid drug, mirogabalin, for recombinant human α2δ1, a voltage-gated calcium channel subunit D Kozai, N Numoto, K Nishikawa, A Kamegawa, S Kawasaki, Y Hiroaki, ... Journal of Molecular Biology 435 (10), 168049, 2023 | 5 | 2023 |
| The insights into calcium ion selectivity provided by ancestral prokaryotic ion channels K Irie Biophysics and Physicobiology 18, 274-283, 2021 | 4 | 2021 |
| Enhancement of the thermostability of mouse claudin-3 on complex formation with the carboxyl-terminal region of Clostridium perfringens enterotoxin improves crystal quality S Nakamura, Y Fujiyoshi, K Irie Acta Crystallographica Section F: Structural Biology Communications 74 (3 …, 2018 | 4 | 2018 |
