| High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities T Hart, M Chandrashekhar, M Aregger, Z Steinhart, KR Brown, ... Cell 163 (6), 1515-1526, 2015 | 1596 | 2015 |
| Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in older adults in England: test negative … JL Bernal, N Andrews, C Gower, C Robertson, J Stowe, E Tessier, ... bmj 373, 2021 | 1240 | 2021 |
| High-throughput mapping of a dynamic signaling network in mammalian cells M Barrios-Rodiles, KR Brown, B Ozdamar, R Bose, Z Liu, RS Donovan, ... Science 307 (5715), 1621-1625, 2005 | 882 | 2005 |
| Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality TE KING JR, MI Schwarz, K Brown, JA Tooze, TV Colby, JA Waldron Jr, ... American journal of respiratory and critical care medicine 164 (6), 1025-1032, 2001 | 819 | 2001 |
| Online predicted human interaction database KR Brown, I Jurisica Bioinformatics 21 (9), 2076-2082, 2005 | 755 | 2005 |
| Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens T Hart, AHY Tong, K Chan, J Van Leeuwen, A Seetharaman, M Aregger, ... G3: Genes, Genomes, Genetics 7 (8), 2719-2727, 2017 | 474 | 2017 |
| Functional genomic landscape of human breast cancer drivers, vulnerabilities, and resistance R Marcotte, A Sayad, KR Brown, F Sanchez-Garcia, J Reimand, M Haider, ... Cell 164 (1), 293-309, 2016 | 460 | 2016 |
| Unequal evolutionary conservation of human protein interactions in interologous networks KR Brown, I Jurisica Genome biology 8, 1-11, 2007 | 381 | 2007 |
| Essential gene profiles in breast, pancreatic, and ovarian cancer cells R Marcotte, KR Brown, F Suarez, A Sayad, K Karamboulas, ... Cancer discovery 2 (2), 172-189, 2012 | 377 | 2012 |
| Measuring error rates in genomic perturbation screens: gold standards for human functional genomics T Hart, KR Brown, F Sircoulomb, R Rottapel, J Moffat Molecular systems biology 10 (7), 733, 2014 | 373 | 2014 |
| Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors Z Steinhart, Z Pavlovic, M Chandrashekhar, T Hart, X Wang, X Zhang, ... Nature medicine 23 (1), 60-68, 2017 | 310 | 2017 |
| Colorectal cancer cells enter a diapause-like DTP state to survive chemotherapy SK Rehman, J Haynes, E Collignon, KR Brown, Y Wang, AML Nixon, ... Cell 184 (1), 226-242. e21, 2021 | 303 | 2021 |
| NAViGaTOR: network analysis, visualization and graphing Toronto KR Brown, D Otasek, M Ali, MJ McGuffin, W Xie, B Devani, IL Toch, ... Bioinformatics 25 (24), 3327-3329, 2009 | 290 | 2009 |
| Idiopathic interstitial pneumonia: do community and academic physicians agree on diagnosis? KR Flaherty, AC Andrei, TE King Jr, G Raghu, TV Colby, A Wells, ... American journal of respiratory and critical care medicine 175 (10), 1054-1060, 2007 | 290 | 2007 |
| Functional genomic landscape of cancer-intrinsic evasion of killing by T cells KA Lawson, CM Sousa, X Zhang, E Kim, R Akthar, JJ Caumanns, Y Yao, ... Nature 586 (7827), 120-126, 2020 | 282 | 2020 |
| Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6 Y Lissanu Deribe, P Wild, A Chandrashaker, J Curak, MHH Schmidt, ... Science signaling 2 (102), ra84-ra84, 2009 | 227 | 2009 |
| A proteome resource of ovarian cancer ascites: integrated proteomic and bioinformatic analyses to identify putative biomarkers L Gortzak-Uzan, A Ignatchenko, AI Evangelou, M Agochiya, KA Brown, ... Journal of proteome research 7 (01), 339-351, 2008 | 191 | 2008 |
| System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes W Zhang, KP Wu, MA Sartori, HB Kamadurai, A Ordureau, C Jiang, ... Molecular cell 62 (1), 121-136, 2016 | 177 | 2016 |
| Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform T Gonatopoulos-Pournatzis, M Aregger, KR Brown, S Farhangmehr, ... Nature biotechnology 38 (5), 638-648, 2020 | 112 | 2020 |
| A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities FJ Vizeacoumar, R Arnold, FS Vizeacoumar, M Chandrashekhar, ... Molecular systems biology 9 (1), 696, 2013 | 108 | 2013 |
Jason MoffatSenior Scientist & Program Head, Genetics & Genome Biology, Sickkids Hospital; Professor, UofT在 utoronto.ca 的电子邮件经过验证
