| Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space EK Makowski, PC Kinnunen, J Huang, L Wu, MD Smith, T Wang, ... Nature communications 13 (1), 3788, 2022 | 75 | 2022 |
| An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence CH Lee, TH Kang, O Godon, M Watanabe, G Delidakis, CM Gillis, ... Nature communications 10 (1), 5031, 2019 | 66 | 2019 |
| Discovery-stage identification of drug-like antibodies using emerging experimental and computational methods EK Makowski, L Wu, P Gupta, PM Tessier MAbs 13 (1), 1895540, 2021 | 35 | 2021 |
| Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis JM Zupancic, AA Desai, JS Schardt, G Pornnoppadol, EK Makowski, ... Cell Chemical Biology 28 (9), 1379-1388. e7, 2021 | 32 | 2021 |
| Engineered multivalent nanobodies potently and broadly neutralize SARS‐CoV‐2 variants JM Zupancic, JS Schardt, AA Desai, EK Makowski, MD Smith, ... Advanced therapeutics 4 (8), 2100099, 2021 | 32 | 2021 |
| Highly sensitive detection of antibody nonspecific interactions using flow cytometry EK Makowski, L Wu, AA Desai, PM Tessier MAbs 13 (1), 1951426, 2021 | 25 | 2021 |
| Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity AA Desai, MD Smith, Y Zhang, EK Makowski, JE Gerson, E Ionescu, ... Journal of Biological Chemistry 296, 2021 | 23 | 2021 |
| Ultradilute measurements of self-association for the identification of antibodies with favorable high-concentration solution properties CG Starr, EK Makowski, L Wu, B Berg, JS Kingsbury, YR Gokarn, ... Molecular Pharmaceutics 18 (7), 2744-2753, 2021 | 22 | 2021 |
| Antibodies with weakly basic isoelectric points minimize trade-offs between formulation and physiological colloidal properties P Gupta, EK Makowski, S Kumar, Y Zhang, JM Scheer, PM Tessier Molecular pharmaceutics 19 (3), 775-787, 2022 | 19 | 2022 |
| Mutational analysis of SARS-CoV-2 variants of concern reveals key tradeoffs between receptor affinity and antibody escape EK Makowski, JS Schardt, MD Smith, PM Tessier PLOS Computational Biology 18 (5), e1010160, 2022 | 16 | 2022 |
| Computational optimization of antibody humanness and stability by systematic energy-based ranking A Tennenhouse, L Khmelnitsky, R Khalaila, N Yeshaya, A Noronha, ... Nature biomedical engineering 8 (1), 30-44, 2024 | 13 | 2024 |
| Reduction of therapeutic antibody self-association using yeast-display selections and machine learning EK Makowski, H Chen, M Lambert, EM Bennett, NS Eschmann, Y Zhang, ... MAbs 14 (1), 2146629, 2022 | 12 | 2022 |
| Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening JS Schardt, G Pornnoppadol, AA Desai, KS Park, JM Zupancic, ... Scientific Reports 11 (1), 20738, 2021 | 12 | 2021 |
| Optimization of therapeutic antibodies for reduced self-association and non-specific binding via interpretable machine learning EK Makowski, T Wang, JM Zupancic, J Huang, L Wu, JS Schardt, ... Nature Biomedical Engineering 8 (1), 45-56, 2024 | 11 | 2024 |
| Simplifying complex antibody engineering using machine learning EK Makowski, HT Chen, PM Tessier Cell Systems 14 (8), 667-675, 2023 | 6 | 2023 |
| Improving antibody drug development using bionanotechnology EK Makowski, JS Schardt, PM Tessier Current opinion in biotechnology 74, 137-145, 2022 | 4 | 2022 |
| Directed evolution of conformation‐specific antibodies for sensitive detection of polypeptide aggregates in therapeutic drug formulations W Lou, SD Stimple, AA Desai, EK Makowski, S Kalyoncu, JE Mogensen, ... Biotechnology and Bioengineering 118 (2), 797-808, 2021 | 3 | 2021 |
| Position-Specific Enrichment Ratio Matrix scores predict antibody variant properties from deep sequencing data MD Smith, MA Case, EK Makowski, PM Tessier Bioinformatics 39 (9), btad446, 2023 | 2 | 2023 |
| Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates JM Zupancic, MD Smith, H Trzeciakiewicz, ME Skinner, SP Ferris, ... Frontiers in Immunology 14, 1164080, 2023 | 2 | 2023 |
| Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrils AA Desai, JM Zupancic, H Trzeciakiewicz, JE Gerson, KN DuBois, ... bioRxiv, 2023.07. 04.547698, 2023 | 2 | 2023 |
