| Suppression of cancer relapse and metastasis by inhibiting cancer stemness Y Li, HA Rogoff, S Keates, Y Gao, S Murikipudi, K Mikule, D Leggett, W Li, ... Proceedings of the National Academy of Sciences 112 (6), 1839-1844, 2015 | 506 | 2015 |
| Centrosome control of the cell cycle S Doxsey, W Zimmerman, K Mikule Trends in cell biology 15 (6), 303-311, 2005 | 376 | 2005 |
| Loss of centrosome integrity induces p38—p53—p21-dependent G1—S arrest K Mikule, B Delaval, P Kaldis, A Jurcyzk, P Hergert, S Doxsey Nature cell biology 9 (2), 160-170, 2007 | 358 | 2007 |
| Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1 J Wu, K Mikule, W Wang, N Su, P Petteruti, F Gharahdaghi, E Code, X Zhu, ... ACS chemical biology 8 (10), 2201-2208, 2013 | 171 | 2013 |
| A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor models K Sun, K Mikule, Z Wang, G Poon, A Vaidyanathan, G Smith, ZY Zhang, ... Oncotarget 9 (98), 37080, 2018 | 152 | 2018 |
| Synthetic lethality of PARP inhibitors in combination with MYC blockade is independent of BRCA status in triple-negative breast cancer JPW Carey, C Karakas, T Bui, X Chen, S Vijayaraghavan, Y Zhao, J Wang, ... Cancer research 78 (3), 742-757, 2018 | 125 | 2018 |
| Growth cone collapse induced by semaphorin 3A requires 12/15-lipoxygenase K Mikule, JC Gatlin, BA de la Houssaye, KH Pfenninger Journal of Neuroscience 22 (12), 4932-4941, 2002 | 96 | 2002 |
| Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering JW Johannes, L Almeida, K Daly, AD Ferguson, SE Grosskurth, H Guan, ... Bioorganic & medicinal chemistry letters 25 (24), 5743-5747, 2015 | 62 | 2015 |
| Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening B Yang, ML Lamb, T Zhang, EJ Hennessy, G Grewal, L Sha, ... Journal of medicinal chemistry 57 (23), 9958-9970, 2014 | 49 | 2014 |
| Thrombin-induced growth cone collapse: involvement of phospholipase A2 and eicosanoid generation BA de la Houssaye, K Mikule, D Nikolic, KH Pfenninger Journal of Neuroscience 19 (24), 10843-10855, 1999 | 45 | 1999 |
| Pharmacological inhibition of PARP6 triggers multipolar spindle formation and elicits therapeutic effects in breast cancer Z Wang, SE Grosskurth, T Cheung, P Petteruti, J Zhang, X Wang, W Wang, ... Cancer research 78 (23), 6691-6702, 2018 | 43 | 2018 |
| Eicosanoid Activation of Protein Kinase C ϵ: INVOLVEMENT IN GROWTH CONE REPELLENT SIGNALING K Mikule, S Sunpaweravong, JC Gatlin, KH Pfenninger Journal of Biological Chemistry 278 (23), 21168-21177, 2003 | 41 | 2003 |
| Selective induction of necrotic cell death in cancer cells by β-lapachone through activation of DNA damage response pathway X Sun, Y Li, W Li, B Zhang, AJ Wang, J Sun, K Mikule, Z Jiang, CJ Li Cell Cycle 5 (17), 2029-2035, 2006 | 40 | 2006 |
| SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent S Helmke, K Lohse, K Mikule, MR Wood, KH Pfenninger Journal of cell science 111 (16), 2465-2475, 1998 | 33 | 1998 |
| Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts Á Póti, K Berta, Y Xiao, O Pipek, GT Klus, T Ried, I Csabai, K Wilcoxen, ... British Journal of Cancer 119 (11), 1392-1400, 2018 | 23 | 2018 |
| The IKK inhibitor BMS-345541 affects multiple mitotic cell cycle transitions H Blazkova, C Von Schubert, K Mikule, R Schwab, N Angliker, ... Cell Cycle 6 (20), 2531-2540, 2007 | 22 | 2007 |
| Discovery of IACS-9779 and IACS-70465 as potent inhibitors targeting indoleamine 2, 3-dioxygenase 1 (IDO1) apoenzyme MM Hamilton, F Mseeh, TJ McAfoos, PG Leonard, NJ Reyna, AL Harris, ... Journal of Medicinal Chemistry 64 (15), 11302-11329, 2021 | 21 | 2021 |
| Discovery of IACS-9439, a potent, exquisitely selective, and orally bioavailable inhibitor of CSF1R B Czako, JR Marszalek, JP Burke, P Mandal, PG Leonard, JB Cross, ... Journal of medicinal chemistry 63 (17), 9888-9911, 2020 | 17 | 2020 |
| Thrombin Causes Pseudopod Detachment via a Pathway Involving Cytosolic Phospholipase A2 and 12/15- Lipoxygenase Products S Ross, B Essary, BA de la Houssaye, Z Pan, K Mikule, O Mubarak, ... | 15 | 2000 |
| Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering C Gu, ML Lamb, JW Johannes, MA Sylvester, MS Eisman, RA Harrison, ... Bioorganic & Medicinal Chemistry Letters 26 (19), 4775-4780, 2016 | 7 | 2016 |
