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Emerging paradigms in GPCR allostery: implications for drug discovery D Wootten, A Christopoulos, PM Sexton Nature reviews Drug discovery 12 (8), 630-644, 2013 | 514 | 2013 |
Phase-plate cryo-EM structure of a class B GPCR–G-protein complex YL Liang, M Khoshouei, M Radjainia, Y Zhang, A Glukhova, J Tarrasch, ... Nature 546 (7656), 118-123, 2017 | 487 | 2017 |
Lifting the lid on GPCRs: the role of extracellular loops M Wheatley, D Wootten, MT Conner, J Simms, R Kendrick, RT Logan, ... British journal of pharmacology 165 (6), 1688-1703, 2012 | 345 | 2012 |
Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment I Kufareva, M Rueda, V Katritch, RC Stevens, R Abagyan Structure 19 (8), 1108-1126, 2011 | 343 | 2011 |
Structure of the adenosine-bound human adenosine A1 receptor–Gi complex CJ Draper-Joyce, M Khoshouei, DM Thal, YL Liang, ATN Nguyen, ... Nature 558 (7711), 559-563, 2018 | 328 | 2018 |
Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes C De Graaf, D Donnelly, D Wootten, J Lau, PM Sexton, LJ Miller, JM Ahn, ... Pharmacological reviews 68 (4), 954-1013, 2016 | 321 | 2016 |
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex YL Liang, M Khoshouei, A Glukhova, SGB Furness, P Zhao, L Clydesdale, ... Nature 555 (7694), 121-125, 2018 | 302 | 2018 |
Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family BG protein-coupled receptor conformations D Wootten, J Simms, LJ Miller, A Christopoulos, PM Sexton Proceedings of the National Academy of Sciences 110 (13), 5211-5216, 2013 | 232 | 2013 |
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor YL Liang, M Khoshouei, G Deganutti, A Glukhova, C Koole, TS Peat, ... Nature 561 (7724), 492-497, 2018 | 231 | 2018 |
Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner … C Koole, D Wootten, J Simms, C Valant, R Sridhar, OL Woodman, ... Molecular pharmacology 78 (3), 456-465, 2010 | 231 | 2010 |
The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism D Wootten, CA Reynolds, KJ Smith, JC Mobarec, C Koole, EE Savage, ... Cell 165 (7), 1632-1643, 2016 | 145 | 2016 |
Activation of the GLP-1 receptor by a non-peptidic agonist P Zhao, YL Liang, MJ Belousoff, G Deganutti, MM Fletcher, FS Willard, ... Nature 577 (7790), 432-436, 2020 | 134 | 2020 |
Structural basis of Gs and Gi recognition by the human glucagon receptor A Qiao, S Han, X Li, Z Li, P Zhao, A Dai, R Chang, L Tai, Q Tan, X Chu, ... Science 367 (6484), 1346-1352, 2020 | 130 | 2020 |
Ligand-dependent modulation of G protein conformation alters drug efficacy SGB Furness, YL Liang, CJ Nowell, ML Halls, PJ Wookey, E Dal Maso, ... Cell 167 (3), 739-749. e11, 2016 | 129 | 2016 |
Differential GLP-1R binding and activation by peptide and non-peptide agonists X Zhang, MJ Belousoff, P Zhao, AJ Kooistra, TT Truong, SY Ang, ... Molecular Cell 80 (3), 485-500. e7, 2020 | 126 | 2020 |
Rules of engagement: GPCRs and G proteins A Glukhova, CJ Draper-Joyce, RK Sunahara, A Christopoulos, D Wootten, ... ACS pharmacology & translational science 1 (2), 73-83, 2018 | 111 | 2018 |
Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia CJ Draper-Joyce, R Bhola, J Wang, A Bhattarai, ATN Nguyen, ... Nature 597 (7877), 571-576, 2021 | 104 | 2021 |
Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands D Wootten, EE Savage, FS Willard, AB Bueno, KW Sloop, A Christopoulos, ... Molecular pharmacology 83 (4), 822-834, 2013 | 104 | 2013 |
Allostery and biased agonism at class BG protein-coupled receptors D Wootten, LJ Miller, C Koole, A Christopoulos, PM Sexton Chemical reviews 117 (1), 111-138, 2017 | 103 | 2017 |