| Biomarkers in lung cancer screening: achievements, promises, and challenges LM Seijo, N Peled, D Ajona, M Boeri, JK Field, G Sozzi, R Pio, JJ Zulueta, ... Journal of Thoracic Oncology 14 (3), 343-357, 2019 | 426 | 2019 |
| Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis M Garayoa, A Martínez, S Lee, R Pío, WG An, L Neckers, J Trepel, ... Molecular endocrinology 14 (6), 848-862, 2000 | 343 | 2000 |
| Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners R Pıo, A Martı́nez, EJ Unsworth, JA Kowalak, JA Bengoechea, PF Zipfel, ... Journal of Biological Chemistry 276 (15), 12292-12300, 2001 | 339 | 2001 |
| Alternative splicing: an emerging topic in molecular and clinical oncology MJ Pajares, T Ezponda, R Catena, A Calvo, R Pio, LM Montuenga The lancet oncology 8 (4), 349-357, 2007 | 326 | 2007 |
| Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression L Corrales, D Ajona, S Rafail, JJ Lasarte, JI Riezu-Boj, JD Lambris, ... The Journal of Immunology 189 (9), 4674-4683, 2012 | 297 | 2012 |
| Frequent BRG1/SMARCA4–inactivating mutations in human lung cancer cell lines PP Medina, OA Romero, T Kohno, LM Montuenga, R Pio, J Yokota, ... Human mutation 29 (5), 617-622, 2008 | 289 | 2008 |
| The role of complement in tumor growth R Pio, L Corrales, JD Lambris Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging …, 2014 | 239 | 2014 |
| Altered patterns of expression of members of the heterogeneous nuclear ribonucleoprotein (hnRNP) family in lung cancer I Pino, R Pıo, G Toledo, N Zabalegui, S Vicent, N Rey, MD Lozano, ... Lung cancer 41 (2), 131-143, 2003 | 238 | 2003 |
| A combined PD-1/C5a blockade synergistically protects against lung cancer growth and metastasis D Ajona, S Ortiz-Espinosa, H Moreno, T Lozano, MJ Pajares, J Agorreta, ... Cancer discovery 7 (7), 694-703, 2017 | 189 | 2017 |
| Complementing the cancer-immunity cycle R Pio, D Ajona, S Ortiz-Espinosa, A Mantovani, JD Lambris Frontiers in immunology 10, 774, 2019 | 176 | 2019 |
| The effects of adrenomedullin overexpression in breast tumor cells A Martínez, M Vos, L Guédez, G Kaur, Z Chen, M Garayoa, R Pío, ... Journal of the National Cancer Institute 94 (16), 1226-1237, 2002 | 161 | 2002 |
| A gene‐alteration profile of human lung cancer cell lines R Blanco, R Iwakawa, M Tang, T Kohno, B Angulo, R Pio, LM Montuenga, ... Human mutation 30 (8), 1199-1206, 2009 | 157 | 2009 |
| Investigation of complement activation product c4d as a diagnostic and prognostic biomarker for lung cancer D Ajona, MJ Pajares, L Corrales, JL Perez-Gracia, J Agorreta, MD Lozano, ... Journal of the National Cancer Institute 105 (18), 1385-1393, 2013 | 147 | 2013 |
| Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene J Carretero, PP Medina, R Pio, LM Montuenga, M Sanchez-Cespedes Oncogene 23 (22), 4037-4040, 2004 | 145 | 2004 |
| Innate immune mediators in cancer: between defense and resistance P Berraondo, L Minute, D Ajona, L Corrales, I Melero, R Pio Immunological Reviews 274 (1), 290-306, 2016 | 144 | 2016 |
| Complement inhibition in cancer therapy R Pio, D Ajona, JD Lambris Seminars in immunology 25 (1), 54-64, 2013 | 144 | 2013 |
| Expression of complement factor H by lung cancer cells: effects on the activation of the alternative pathway of complement D Ajona, Z Castano, M Garayoa, E Zudaire, MJ Pajares, A Martinez, ... Cancer Research 64 (17), 6310-6318, 2004 | 140 | 2004 |
| Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16, activation of the DNA damage response pathway D Blanco, S Vicent, MF Fraga, I Fernandez-Garcia, J Freire, A Lujambio, ... Neoplasia 9 (10), 840-IN12, 2007 | 137 | 2007 |
| A novel epigenetic signature for early diagnosis in lung cancer A Diaz-Lagares, J Mendez-Gonzalez, D Hervas, M Saigi, MJ Pajares, ... Clinical Cancer Research 22 (13), 3361-3371, 2016 | 132 | 2016 |
| Improving selection criteria for lung cancer screening. The potential role of emphysema P Sanchez-Salcedo, DO Wilson, JP de-Torres, JL Weissfeld, J Berto, ... American journal of respiratory and critical care medicine 191 (8), 924-931, 2015 | 128 | 2015 |
