Two distinct classes of cochaperones compete for the EEVD motif in heat shock protein 70 to tune its chaperone activities OT Johnson, CM Nadel, EC Carroll, T Arhar, JE Gestwicki Journal of Biological Chemistry 298 (3), 2022 | 18 | 2022 |
High-throughput chemical probing of full-length protein–protein interactions JM Song, A Menon, DC Mitchell, OT Johnson, AL Garner ACS combinatorial science 19 (12), 763-769, 2017 | 16 | 2017 |
Multivalent protein–protein interactions are pivotal regulators of eukaryotic Hsp70 complexes OT Johnson, JE Gestwicki Cell Stress and Chaperones 27 (4), 397-415, 2022 | 12 | 2022 |
Analogs of the heat shock protein 70 inhibitor MKT-077 suppress medullary thyroid carcinoma cells SK Hong, D Starenki, OT Johnson, JE Gestwicki, JI Park International journal of molecular sciences 23 (3), 1063, 2022 | 9 | 2022 |
Conformationally responsive dyes enable protein-adaptive differential scanning fluorimetry T Wu, CY Joshua, A Suresh, ZJ Gale-Day, MG Alteen, AS Woo, Z Millbern, ... bioRxiv, 2023 | 8 | 2023 |
A conditionally fluorescent peptide reporter of secondary structure modulation OT Johnson, T Kaur, AL Garner ChemBioChem 20 (1), 40-45, 2019 | 5 | 2019 |
Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models P Xu, JC Yang, S Ning, B Chen, C Nip, Q Wei, L Liu, OT Johnson, AC Gao, ... Pharmacological research 189, 106692, 2023 | 3 | 2023 |
Chemical validation of a druggable site on Hsp27/HSPB1 using in silico solvent mapping and biophysical methods LN Makley, OT Johnson, P Ghanakota, JN Rauch, D Osborn, TS Wu, ... Bioorganic & medicinal chemistry 34, 115990, 2021 | 2 | 2021 |
Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer FJ Echtenkamp, R Ishida, GM Rivera-Marquez, M Maisiak, OT Johnson, ... PNAS nexus 2 (4), pgad115, 2023 | 1 | 2023 |
Two distinct classes of co-chaperones compete for the EEVD motif in heat shock protein 70 (Hsp70) to tune its activity OT Johnson, CM Nadel, EC Carroll, T Arhar, JE Gestwicki bioRxiv, 2021.10. 18.464838, 2021 | 1 | 2021 |
Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes T Wu, JC Yu, A Suresh, ZJ Gale-Day, MG Alteen, AS Woo, Z Millbern, ... Nature Biotechnology, 1-8, 2024 | | 2024 |
A missense mutation in the Hspa8 gene encoding heat shock cognate protein 70 causes neuroaxonal dystrophy in rats M Tanaka, R Fujikawa, T Sekiguchi, J Hernandez, OT Johnson, D Tanaka, ... Frontiers in Neuroscience 18, 1263724, 2024 | | 2024 |
Track: Protein and Ligand-A New Marriage Between an Old Couple Discovering Chemical Tools to Target DnaJB6 in Polyglutamine Diseases O Johnson, S Tripathi, K Herbert, H Carlson, J Gestwicki PROTEIN SCIENCE 32, 2023 | | 2023 |
Adaptation of Chemical Biology Approaches for Dissecting Disordered Protein Dynamics O Johnson | | 2018 |
An Omni-Directional Gage for Measuring the Dynamic Pressure Behind a Shock Front WO Ewing, OT Johnson | | 1962 |