| ERK signalling: a master regulator of cell behaviour, life and fate H Lavoie, J Gagnon, M Therrien Nature reviews Molecular cell biology 21 (10), 607-632, 2020 | 696 | 2020 |
| Regulation of RAF protein kinases in ERK signalling H Lavoie, M Therrien Nature reviews Molecular cell biology 16 (5), 281-298, 2015 | 676 | 2015 |
| A dimerization-dependent mechanism drives RAF catalytic activation T Rajakulendran, M Sahmi, M Lefrançois, F Sicheri, M Therrien Nature 461 (7263), 542-545, 2009 | 532 | 2009 |
| KSR, a novel protein kinase required for RAS signal transduction M Therrien, HC Chang, NM Solomon, FD Karim, DA Wassarman, ... Cell 83 (6), 879-888, 1995 | 508 | 1995 |
| Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene. T Lamonerie, JJ Tremblay, C Lanctôt, M Therrien, Y Gauthier, J Drouin Genes & development 10 (10), 1284-1295, 1996 | 487 | 1996 |
| KSR modulates signal propagation within the MAPK cascade. M Therrien, NR Michaud, GM Rubin, DK Morrison Genes & development 10 (21), 2684-2695, 1996 | 347 | 1996 |
| A Screen for Genes That Function Downstream of Ras1 during Drosophila Eye Development FD Karim, HC Chang, M Therrien, DA Wassarman, T Laverty, GM Rubin Genetics 143 (1), 315-329, 1996 | 293 | 1996 |
| The Ras signaling pathway in Drosophila DA Wassarman, M Therrien, GM Rubin Current opinion in genetics & development 5 (1), 44-50, 1995 | 292 | 1995 |
| A comprehensive map of the mTOR signaling network E Caron, S Ghosh, Y Matsuoka, D Ashton‐Beaucage, M Therrien, ... Molecular systems biology 6 (1), 453, 2010 | 289 | 2010 |
| Inhibition of RAS function through targeting an allosteric regulatory site R Spencer-Smith, A Koide, Y Zhou, RR Eguchi, F Sha, P Gajwani, ... Nature chemical biology 13 (1), 62-68, 2017 | 279 | 2017 |
| Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression AM Cacace, NR Michaud, M Therrien, K Mathes, T Copeland, GM Rubin, ... Molecular and cellular biology 19 (1), 229-240, 1999 | 277 | 1999 |
| KSR is a scaffold required for activation of the ERK/MAPK module F Roy, G Laberge, M Douziech, D Ferland-McCollough, M Therrien Genes & development 16 (4), 427-438, 2002 | 275 | 2002 |
| KSR stimulates Raf-1 activity in a kinase-independent manner NR Michaud, M Therrien, A Cacace, LC Edsall, S Spiegel, GM Rubin, ... Proceedings of the National Academy of Sciences 94 (24), 12792-12796, 1997 | 237 | 1997 |
| CNK, a RAF-binding multidomain protein required for RAS signaling M Therrien, AM Wong, GM Rubin Cell 95 (3), 343-353, 1998 | 209 | 1998 |
| Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O N Mashtalir, S Daou, H Barbour, NN Sen, J Gagnon, I Hammond-Martel, ... Molecular cell 54 (3), 392-406, 2014 | 190 | 2014 |
| KSR and CNK: two scaffolds regulating RAS-mediated RAF activation A Claperon, M Therrien Oncogene 26 (22), 3143-3158, 2007 | 178 | 2007 |
| Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization H Lavoie, N Thevakumaran, G Gavory, JJ Li, A Padeganeh, S Guiral, ... Nature chemical biology 9 (7), 428-436, 2013 | 169 | 2013 |
| Cell-specific helix-loop-helix factor required for pituitary expression of the pro-opiomelanocortin gene M Therrien, J Drouin Molecular and Cellular Biology 13 (4), 2342-2353, 1993 | 162 | 1993 |
| Pituitary pro-opiomelanocortin gene expression requires synergistic interactions of several regulatory elements M Therrien, J Drouin Molecular and Cellular Biology, 1991 | 155 | 1991 |
| Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation N Thevakumaran, H Lavoie, DA Critton, A Tebben, A Marinier, F Sicheri, ... Nature structural & molecular biology 22 (1), 37-43, 2015 | 145 | 2015 |
