| Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia AE Tron, MA Belmonte, A Adam, BM Aquila, LH Boise, E Chiarparin, ... Nature communications 9 (1), 5341, 2018 | 451 | 2018 |
| Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain G Akçay, MA Belmonte, B Aquila, C Chuaqui, AW Hird, ML Lamb, ... Nature chemical biology 12 (11), 931-936, 2016 | 192 | 2016 |
| Structure based design of non-natural peptidic macrocyclic Mcl-1 inhibitors JW Johannes, S Bates, C Beigie, MA Belmonte, J Breen, S Cao, ... ACS medicinal chemistry letters 8 (2), 239-244, 2017 | 73 | 2017 |
| Development of frataxin gene expression measures for the evaluation of experimental treatments in Friedreich’s ataxia HL Plasterer, EC Deutsch, M Belmonte, E Egan, DR Lynch, JR Rusche PLoS One 8 (5), e63958, 2013 | 41 | 2013 |
| Abstract DDT01-02: AZD5991: A potent and selective macrocyclic inhibitor of Mcl-1 for treatment of hematologic cancers AW Hird, JP Secrist, A Adam, MA Belmonte, E Gangl, F Gibbons, ... Cancer Research 77 (13_Supplement), DDT01-02-DDT01-02, 2017 | 29 | 2017 |
| Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling NR Michaud, Y Wang, KA McEachern, JJ Jordan, AM Mazzola, ... Molecular cancer therapeutics 13 (2), 386-398, 2014 | 28 | 2014 |
| The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells S Kabir, J Cidado, C Andersen, C Dick, PC Lin, T Mitros, H Ma, SH Baik, ... Elife 8, e44288, 2019 | 24 | 2019 |
| Discovery and optimization of covalent Bcl-xL antagonists H Mukherjee, N Su, MA Belmonte, D Hargreaves, J Patel, S Tentarelli, ... Bioorganic & Medicinal Chemistry Letters 29 (23), 126682, 2019 | 16 | 2019 |
| Evaluation of Mcl-1 inhibitors in preclinical models of multiple myeloma MA Belmonte, A Adam, D Borrelli, D Bhavsar, C Bebernitz, A Hird, ... Blood 124 (21), 3428, 2014 | 9 | 2014 |
| Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Nat. Commun. 9, 5341 AE Tron, MA Belmonte, A Adam, BM Aquila, LH Boise, E Chiarparin, ... | 6 | 2018 |
| Multiscale Model Identifies Improved Schedule for Treatment of Acute Myeloid Leukemia In Vitro With the Mcl‐1 Inhibitor AZD5991 A Goliaei, HA Woods, AE Tron, MA Belmonte, JP Secrist, D Ferguson, ... CPT: Pharmacometrics & Systems Pharmacology 9 (10), 561-570, 2020 | 3 | 2020 |
| Macrocyclic mcl1 inhibitors for treating cancer A Hird, MA BELMONTE, Y Wenzhan, JP SECRIST, DW ROBBINS, ... | 1 | 2020 |
| Selective Mcl-1 inhibition by AZD5991 induces on-target cell death and achieves antitumor activity in multiple myeloma and acute myeloid leukemia AE Tron, MA Belmonte, S Criscione, EA Clark, E Gangl, FD Gibbons, ... Cancer Research 78 (13_Supplement), 302-302, 2018 | 1 | 2018 |
| Compostos, sais farmaceuticamente aceitáveis, forma sólida, composição farmacêutica e uso de composto A Hird, MA Belmonte, Y Wenzhan, JP Secrist, DW Robbins, SL Kazmirski, ... | | 2024 |
| Mcl-1 inhibitors and methods of use thereof A Hird, M Belmonte, Y Wenzhan, P Secrist, D Robbins, S Kazmirski, D Wu, ... US Patent 11,472,816, 2022 | | 2022 |
| Identification of the mechanism of action of CYT-0851, an inhibitor of monocarboxylate transporter (MCT) mediated lactate transport B Bradley, MA Belmonte, S Kansara, JL Blank, L Cryan, NM Reilly, ... European Journal of Cancer 174, S24-S25, 2022 | | 2022 |
| MCL-1 inhibitors and methods of use thereof A Hird, Y Wenzhan, D Robbins, S Kazmirski, D Wu, B Peng, J Johannes, ... US Patent 10,889,594, 2021 | | 2021 |
| Inhibidores de MCL1 macrocíclicos para tratar el cáncer A Hird, M Belmonte, W Yang, J Secrist, D Robbins, S Kazmirski, D Wu, ... ES Patent App. 17,720,720 T, 2020 | | 2020 |
| Makrociklički mcl1 inhibitori za tretman raka A Hird, MA Belmonte, W Yang, JP Secrist, DW Robbins, SL Kazmirski, ... | | 2020 |
| Inhibiteurs de mcl1 macrocycliques pour le traitement du cancer A Hird, M Belmonte, W Yang, J Secrist, D Robbins, S Kazmirski, D Wu, ... | | 2020 |
