| Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging K Young, E Eudy, R Bell, MA Loberg, T Stearns, D Sharma, L Velten, ... Cell stem cell 28 (8), 1473-1482. e7, 2021 | 114 | 2021 |
| Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis MA Loberg, RK Bell, LO Goodwin, E Eudy, LA Miles, JM SanMiguel, ... Leukemia 33 (7), 1635-1649, 2019 | 101 | 2019 |
| Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging K Young, S Borikar, R Bell, L Kuffler, V Philip, JJ Trowbridge Journal of Experimental Medicine 213 (11), 2259-2267, 2016 | 92 | 2016 |
| BMP9 regulates endoglin-dependent chemokine responses in endothelial cells K Young, B Conley, D Romero, E Tweedie, C O'Neill, I Pinz, L Brogan, ... Blood, The Journal of the American Society of Hematology 120 (20), 4263-4273, 2012 | 88 | 2012 |
| Endoglin regulates cancer–stromal cell interactions in prostate tumors D Romero, C O'Neill, A Terzic, L Contois, K Young, BA Conley, ... Cancer research 71 (10), 3482-3493, 2011 | 77 | 2011 |
| Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells J George, A Uyar, K Young, L Kuffler, K Waldron-Francis, E Marquez, ... Nature communications 7 (1), 12166, 2016 | 61 | 2016 |
| Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis JM SanMiguel, K Young, JJ Trowbridge Experimental hematology 91, 1-9, 2020 | 47 | 2020 |
| BMP9 crosstalk with the hippo pathway regulates endothelial cell matricellular and chemokine responses K Young, E Tweedie, B Conley, J Ames, ML FitzSimons, P Brooks, L Liaw, ... PloS one 10 (4), e0122892, 2015 | 46 | 2015 |
| Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis JM SanMiguel, E Eudy, MA Loberg, KA Young, JJ Mistry, KD Mujica, ... Cancer discovery 12 (12), 2763-2773, 2022 | 40 | 2022 |
| Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation ES Khokhar, S Borikar, E Eudy, T Stearns, K Young, JJ Trowbridge Experimental hematology 82, 43-52. e4, 2020 | 25 | 2020 |
| Cell-extrinsic stressors from the aging bone marrow (BM) microenvironment promote Dnmt3a-mutant clonal hematopoiesis JM SanMiguel, M Loberg, S Heuer, T Stearns, K Young, J Trowbridge Blood 134, 5, 2019 | 13 | 2019 |
| Endoglin is required in Pax3-derived cells for embryonic blood vessel formation K Young, LT Krebs, E Tweedie, B Conley, M Mancini, HM Arthur, L Liaw, ... Developmental biology 409 (1), 95-105, 2016 | 7 | 2016 |
| Heritable genetic background alters survival and phenotype of Mll-AF9-induced leukemias K Young, MA Loberg, E Eudy, LS Schwartz, KD Mujica, JJ Trowbridge Experimental hematology 89, 61-67. e3, 2020 | 6 | 2020 |
| Hematopoietic stem and progenitor cell aging is initiated at middle age through decline in local insulin-like growth factor 1 (IGF1) K Young, E Eudy, R Bell, M Loberg, T Stearns, L Velten, S Haas, ... BioRxiv, 2020.07. 11.198846, 2020 | 3 | 2020 |
| Decline in Insulin-like Growth Factor-1 (IGF1) from Aged Mesenchymal Stromal Cells Is a Targetable Mechanism to Rescue Hematopoietic Stem Cell Aging K Young, E Eudy, M Loberg, R Bell, J Trowbridge Blood 134, 526, 2019 | 3 | 2019 |
| Transcriptional and functional consequences of oncostatin M signaling on young Dnmt3a-mutant hematopoietic stem cells LS Schwartz, KA Young, TM Stearns, N Boyer, KD Mujica, JJ Trowbridge Experimental hematology 130, 104131, 2024 | 2 | 2024 |
| Metformin reduces the clonal fitness of Dnmt3aR878H hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state M Hosseini, V Voisin, A Chegini, A Varesi, S Cathelin, DM Ayyathan, ... Research Square, 2024 | 1 | 2024 |
| Oncostatin M is a Master Regulator of an Inflammatory Network in Dnmt3a-Mutant Hematopoietic Stem Cells LS Schwartz, KA Young, TM Stearns, N Boyer, KD Mujica, JJ Trowbridge bioRxiv, 2023.07. 12.548764, 2023 | 1 | 2023 |
| Bone Marrow Stromal Cell Senescence Induced By Dnmt3a-Mutant Hematopoietic Stem and Progenitor Cells Accelerates Clonal Hematopoiesis and Progression to Leukemia JJ Mistry, KA Young, JJ Trowbridge Blood 140 (Supplement 1), 1265-1265, 2022 | 1 | 2022 |
| The Middle-Aged Bone Marrow Microenvironment Drives Hematopoietic Stem Cell Aging through Altered Production of Insulin-like Growth Factor-1 (IGF1) K Young, M Loberg, E Eudy, R Bell, JJ Trowbridge Blood 132, 5091, 2018 | 1 | 2018 |
