Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition JL Leight, MA Wozniak, S Chen, ML Lynch, CS Chen Molecular biology of the cell 23 (5), 781-791, 2012 | 502 | 2012 |
Negative normal stress in semiflexible biopolymer gels PA Janmey, ME McCormick, S Rammensee, JL Leight, PC Georges, ... Nature materials 6 (1), 48-51, 2007 | 466 | 2007 |
Development of a cellularly degradable PEG hydrogel to promote articular cartilage extracellular matrix deposition BV Sridhar, JL Brock, JS Silver, JL Leight, MA Randolph, KS Anseth Advanced healthcare materials 4 (5), 702-713, 2015 | 208 | 2015 |
Filamin A–β1 integrin complex tunes epithelial cell response to matrix tension S Gehler, M Baldassarre, Y Lad, JL Leight, MA Wozniak, KM Riching, ... Molecular biology of the cell 20 (14), 3224-3238, 2009 | 148 | 2009 |
Extracellular matrix remodeling and stiffening modulate tumor phenotype and treatment response JL Leight, AP Drain, VM Weaver Annual Review of Cancer Biology 1 (1), 313-334, 2017 | 135 | 2017 |
Demystifying the effects of a three‐dimensional microenvironment in tissue morphogenesis KR Johnson, JL Leight, VM Weaver Methods in cell biology 83, 547-583, 2007 | 118 | 2007 |
Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate JL Leight, DL Alge, AJ Maier, KS Anseth Biomaterials 34 (30), 7344-7352, 2013 | 96 | 2013 |
Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness EY Tokuda, JL Leight, KS Anseth Biomaterials 35 (14), 4310-4318, 2014 | 72 | 2014 |
Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition JL Leight, EY Tokuda, CE Jones, AJ Lin, KS Anseth Proceedings of the National Academy of Sciences 112 (17), 5366-5371, 2015 | 70 | 2015 |
Stromal PTEN regulates extracellular matrix organization in the mammary gland CE Jones, AM Hammer, YJ Cho, GM Sizemore, E Cukierman, LD Yee, ... Neoplasia 21 (1), 132-145, 2019 | 48 | 2019 |
Synthesis of microgel sensors for spatial and temporal monitoring of protease activity DS Shin, EY Tokuda, JL Leight, CE Miksch, TE Brown, KS Anseth ACS biomaterials science & engineering 4 (2), 378-387, 2018 | 44 | 2018 |
Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer AP Drain, N Zahir, JJ Northey, H Zhang, PJ Huang, O Maller, JN Lakins, ... Journal of Experimental Medicine 218 (5), e20191360, 2021 | 42 | 2021 |
MDM2 Derived from Dedifferentiated Liposarcoma Extracellular Vesicles Induces MMP2 Production from Preadipocytes L Casadei, F Calore, DA Braggio, A Zewdu, AA Deshmukh, P Fadda, ... Cancer research 79 (19), 4911-4922, 2019 | 34 | 2019 |
Matrix-metalloproteinase expression and gelatinase activity in the avian retina and their influence on Müller glia proliferation WA Campbell IV, A Deshmukh, S Blum, L Todd, N Mendonca, J Weist, ... Experimental neurology 320, 112984, 2019 | 26 | 2019 |
In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness C Wormsbaecher, AR Hindman, A Avendano, M Cortes-Medina, ... Breast Cancer Research 22, 1-12, 2020 | 19 | 2020 |
Manipulation of 3D cluster size and geometry by release from 2D micropatterns JL Leight, WF Liu, RR Chaturvedi, S Chen, MT Yang, S Raghavan, ... Cellular and molecular bioengineering 5, 299-306, 2012 | 18 | 2012 |
Myoferlin regulates epithelial cancer cell plasticity and migration through autocrine TGF-β1 signaling VR Barnhouse, JL Weist, VC Shukla, SN Ghadiali, DA Kniss, JL Leight Oncotarget 9 (27), 19209, 2018 | 16 | 2018 |
Detection of proteolytic activity by covalent tethering of fluorogenic substrates in zymogram gels AA Deshmukh, JL Weist, JL Leight BioTechniques 64 (5), 203-210, 2018 | 15 | 2018 |
Cellular mechanics of primary human cervical fibroblasts: influence of progesterone and a pro-inflammatory cytokine V Shukla, V Barnhouse, WE Ackerman, TL Summerfield, HM Powell, ... Annals of Biomedical Engineering 46, 197-207, 2018 | 13 | 2018 |
Tissue engineering: development of a cellularly degradable PEG hydrogel to promote articular cartilage extracellular matrix deposition (Adv. Healthcare Mater. 5/2015) BV Sridhar, JL Brock, JS Silver, JL Leight, MA Randolph, KS Anseth Advanced healthcare materials 4 (5), 635-635, 2015 | 12 | 2015 |