High-level resistance of Staphylococcus aureus to β-lactam antibiotics mediated by penicillin-binding protein 4 (PBP4) SM Hamilton, JAN Alexander, EJ Choo, L Basuino, TM da Costa, ... Antimicrobial agents and chemotherapy 61 (6), 10.1128/aac. 02727-16, 2017 | 81 | 2017 |
Structural and kinetic characterization of diazabicyclooctanes as dual inhibitors of both serine-β-lactamases and penicillin-binding proteins AM King, DT King, S French, E Brouillette, A Asli, JAN Alexander, ... ACS chemical biology 11 (4), 864-868, 2016 | 65 | 2016 |
Structural and kinetic analysis of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureus JAN Alexander, SS Chatterjee, SM Hamilton, LD Eltis, HF Chambers, ... Journal of Biological Chemistry, 2018 | 58 | 2018 |
Recognition of peptidoglycan fragments by the transpeptidase PBP4 from Staphylococcus aureus R Maya-Martinez, JA Alexander, C Otten, I Ayala, D Vollmer, C Bougault, ... Frontiers in microbiology, 2019 | 34 | 2019 |
PBP4 activity and its overexpression are necessary for PBP4-mediated high-level β-lactam resistance L Basuino, A Jousselin, JAN Alexander, NCJ Strynadka, MG Pinho, ... Journal of Antimicrobial Chemotherapy 73 (5), 1177-1180, 2018 | 26 | 2018 |
Derivation of a continuous myogenic cell culture from an embryo of common killifish, Fundulus heteroclitus SJ Gignac, NTK Vo, MS Mikhaeil, JAN Alexander, DL MacLatchy, ... Comparative Biochemistry and Physiology Part A: Molecular & Integrative …, 2014 | 25 | 2014 |
Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus JAN Alexander, LJ Worrall, J Hu, M Vuckovic, N Satishkumar, R Poon, ... Nature 613 (7943), 375-382, 2023 | 17 | 2023 |
Emerging structural insights into C-type glycosyltransferases JAN Alexander, KP Locher Current Opinion in Structural Biology 79, 102547, 2023 | 14 | 2023 |
Structural insight into the Staphylococcus aureus ATP-driven exporter of virulent peptide toxins N Zeytuni, SW Dickey, J Hu, HT Chou, LJ Worrall, JAN Alexander, ... Science advances 6 (40), eabb8219, 2020 | 14 | 2020 |
Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus JAN Alexander, M Radaeva, DT King, HF Chambers, A Cherkasov, ... Journal of Biological Chemistry 295 (32), 10870-10884, 2020 | 11 | 2020 |
PBP4-mediated β-lactam resistance among clinical strains of Staphylococcus aureus N Satishkumar, JAN Alexander, R Poon, E Buggeln, MA Argudín, ... Journal of Antimicrobial Chemotherapy 76 (9), 2268-2272, 2021 | 6 | 2021 |
Development of a continuous cell line from larval Atlantic cod (Gadus morhua) and its use in the study of the microsporidian, Loma morhua MJ MacLeod, NTK Vo, MS Mikhaeil, SR Monaghan, JAN Alexander, ... Journal of fish diseases 41 (9), 1359-1372, 2018 | 3 | 2018 |
Synthesis and characterisation of fluorescent substrates for eukaryotic protein N-glycosylation MM de Capitani, AS Ramírez, L Rossi, JAN Alexander, S De Lorenzo, ... Tetrahedron 136, 133361, 2023 | 1 | 2023 |
Understanding Staphylococcus aureus β-lactam resistance: a structural investigation JAN Alexander University of British Columbia, 2020 | | 2020 |