Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network MJ McConnell, JV Moran, A Abyzov, S Akbarian, T Bae, I Cortes-Ciriano, ... Science 356 (6336), eaal1641, 2017 | 252 | 2017 |
Mesenchymal stem cell transplantation promotes neurogenesis and ameliorates autism related behaviors in BTBR mice H Segal‐Gavish, G Karvat, N Barak, R Barzilay, J Ganz, L Edry, I Aharony, ... Autism Research 9 (1), 17-32, 2016 | 95 | 2016 |
Landmarks of human embryonic development inscribed in somatic mutations S Bizzotto, Y Dou, J Ganz, RN Doan, M Kwon, CL Bohrson, SN Kim, ... Science 371 (6535), 1249-1253, 2021 | 82 | 2021 |
Cell replacement therapy for Parkinson’s disease: how close are we to the clinic? J Ganz, N Lev, E Melamed, D Offen Expert review of neurotherapeutics 11 (9), 1325-1339, 2011 | 48 | 2011 |
A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models J Ganz, T Shacham, M Kramer, M Shenkman, H Eiger, N Weinberg, ... Scientific reports 10 (1), 6875, 2020 | 47 | 2020 |
Astrocyte-like cells derived from human oral mucosa stem cells provide neuroprotection in vitro and in vivo J Ganz, I Arie, T Ben-Zur, M Dadon-Nachum, S Pour, S Araidy, S Pitaru, ... Stem cells translational medicine 3 (3), 375-386, 2014 | 43 | 2014 |
Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements LJ Luquette, MB Miller, Z Zhou, CL Bohrson, Y Zhao, H Jin, D Gulhan, ... Nature genetics 54 (10), 1564-1571, 2022 | 42 | 2022 |
Comprehensive identification of somatic nucleotide variants in human brain tissue Y Wang, T Bae, J Thorpe, MA Sherman, AG Jones, S Cho, K Daily, Y Dou, ... Genome biology 22, 1-32, 2021 | 37 | 2021 |
Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability T Bae, L Fasching, Y Wang, JH Shin, M Suvakov, Y Jang, S Norton, ... Science 377 (6605), 511-517, 2022 | 36 | 2022 |
Harnessing neurogenesis for the possible treatment of Parkinson's disease O Lamm, J Ganz, E Melamed, D Offen Journal of Comparative Neurology 522 (12), 2817-2830, 2014 | 36 | 2014 |
Implantation of 3D constructs embedded with oral mucosa-derived cells induces functional recovery in rats with complete spinal cord transection J Ganz, E Shor, S Guo, A Sheinin, I Arie, I Michaelevski, S Pitaru, D Offen, ... Frontiers in Neuroscience 11, 589, 2017 | 33 | 2017 |
Rates and patterns of clonal oncogenic mutations in the normal human brain J Ganz, EA Maury, B Becerra, S Bizzotto, RN Doan, CJ Kenny, T Shin, ... Cancer discovery 12 (1), 172-185, 2022 | 28 | 2022 |
Dopaminergic-like neurons derived from oral mucosa stem cells by developmental cues improve symptoms in the hemi-parkinsonian rat model J Ganz, I Arie, S Buch, TB Zur, Y Barhum, S Pour, S Araidy, S Pitaru, ... PLoS One 9 (6), e100445, 2014 | 26 | 2014 |
MIPP-Seq: ultra-sensitive rapid detection and validation of low-frequency mosaic mutations RN Doan, MB Miller, SN Kim, RE Rodin, J Ganz, S Bizzotto, KS Morillo, ... BMC Medical Genomics 14, 1-13, 2021 | 18 | 2021 |
Mesenchymal stem cells protect from sub-chronic phencyclidine insult in vivo and counteract changes in astrocyte gene expression in vitro R Barzilay, J Ganz, O Sadan, T Ben-Zur, Z Bren, N Hinden, M Taler, N Lev, ... European Neuropsychopharmacology 23 (9), 1115-1123, 2013 | 17 | 2013 |
Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions EA Maury, MA Sherman, G Genovese, TG Gilgenast, T Kamath, SJ Burris, ... Cell genomics 3 (8), 2023 | 9 | 2023 |
Cell lineage analysis with somatic mutations reveals late divergence of neuronal cell types and cortical areas in human cerebral cortex SN Kim, VV Viswanadham, RN Doan, Y Dou, S Bizzotto, S Khoshkhoo, ... bioRxiv, 2023 | 5 | 2023 |
Stem cell-derived neural cells for cell therapy in neurological disorders S Pitaru, J Ganz, D Offen, E Melamed US Patent 9,717,761, 2017 | 5 | 2017 |
Contrasting patterns of somatic mutations in neurons and glia reveal differential predisposition to disease in the aging human brain J Ganz, LJ Luquette, S Bizzotto, CL Bohrson, H Jin, MB Miller, Z Zhou, ... bioRxiv, 2023 | 4 | 2023 |
Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia AY Huang, Z Zhou, M Talukdar, MB Miller, B Chhouk, L Enyenihi, I Rosen, ... bioRxiv, 2024 | 1 | 2024 |