The role of AMPK activation for cardioprotection in doxorubicin-induced cardiotoxicity KN Timm, DJ Tyler Cardiovascular drugs and therapy 34 (2), 255-269, 2020 | 140 | 2020 |
Fatty acids prevent hypoxia-inducible factor-1α signaling through decreased succinate in diabetes MS Dodd, ML Sousa Fialho, CN Montes Aparicio, M Kerr, KN Timm, ... JACC: Basic to Translational Science 3 (4), 485-498, 2018 | 70 | 2018 |
Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse I Marco‐Rius, MCD Tayler, MI Kettunen, TJ Larkin, KN Timm, EM Serrao, ... NMR in Biomedicine 26 (12), 1696-1704, 2013 | 63 | 2013 |
Neutrophils incite and macrophages avert electrical storm after myocardial infarction J Grune, AJM Lewis, M Yamazoe, M Hulsmans, D Rohde, L Xiao, ... Nature cardiovascular research 1 (7), 649-664, 2022 | 50 | 2022 |
Hyperpolarized [U‐2H, U‐13C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells KN Timm, J Hartl, MA Keller, DE Hu, MI Kettunen, TB Rodrigues, M Ralser, ... Magnetic Resonance in Medicine 74 (6), 1543-1547, 2015 | 46 | 2015 |
Assessing oxidative stress in tumors by measuring the rate of hyperpolarized [1-13C] dehydroascorbic acid reduction using 13C magnetic resonance spectroscopy KN Timm, DE Hu, M Williams, AJ Wright, MI Kettunen, BWC Kennedy, ... Journal of Biological Chemistry 292 (5), 1737-1748, 2017 | 43 | 2017 |
Detection of transgene expression using hyperpolarized 13C urea and diffusion‐weighted magnetic resonance spectroscopy PS Patrick, MI Kettunen, SS Tee, TB Rodrigues, E Serrao, KN Timm, ... Magnetic resonance in medicine 73 (4), 1401-1406, 2015 | 37 | 2015 |
Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI KN Timm, C Perera, V Ball, JA Henry, JJ Miller, M Kerr, JA West, ... Communications biology 3 (1), 692, 2020 | 34 | 2020 |
Cancer therapy-induced cardiotoxicity—a metabolic perspective on pathogenesis, diagnosis and therapy A Choksey, KN Timm International Journal of Molecular Sciences 23 (1), 441, 2021 | 32 | 2021 |
Imaging tumor metabolism to assess disease progression and treatment response KN Timm, BWC Kennedy, KM Brindle Clinical Cancer Research 22 (21), 5196-5203, 2016 | 22 | 2016 |
13C magnetic resonance spectroscopic imaging of hyperpolarized [1‐13C, U‐2H5] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in … P Dzien, MI Kettunen, I Marco‐Rius, EM Serrao, TB Rodrigues, TJ Larkin, ... Magnetic Resonance in Medicine 73 (5), 1733-1740, 2015 | 21 | 2015 |
Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol M Kerr, JJ Miller, D Thapa, S Stiewe, KN Timm, CNM Aparicio, I Scott, ... JCI insight 5 (17), 2020 | 20 | 2020 |
Cardiac applications of hyperpolarised magnetic resonance KN Timm, JJ Miller, JA Henry, DJ Tyler Progress in nuclear magnetic resonance spectroscopy 106, 66-87, 2018 | 19 | 2018 |
Metabolic effects of doxorubicin on the rat liver assessed with hyperpolarized MRI and metabolomics KN Timm, V Ball, JJ Miller, D Savic, JA West, JL Griffin, DJ Tyler Frontiers in Physiology 12, 782745, 2022 | 13 | 2022 |
Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR I Marco-Rius, AJ Wright, D Hu, D Savic, JJ Miller, KN Timm, D Tyler, ... Magnetic Resonance Materials in Physics, Biology and Medicine 34, 49-56, 2021 | 12 | 2021 |
Hyperpolarized magnetic resonance shows that the anti‐ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post‐ischemic … D Savic, V Ball, L Holzner, D Hauton, KN Timm, MK Curtis, LC Heather, ... NMR in Biomedicine 34 (4), e4471, 2021 | 11 | 2021 |
L-Carnitine stimulates in vivo carbohydrate metabolism in the type 1 diabetic heart as demonstrated by hyperpolarized MRI D Savic, V Ball, MK Curtis, ML Sousa Fialho, KN Timm, D Hauton, J West, ... Metabolites 11 (3), 191, 2021 | 9 | 2021 |
Mechanisms of trastuzumab induced cardiotoxicity–is exercise a potential treatment? H Eaton, KN Timm Cardio-Oncology 9 (1), 22, 2023 | 8 | 2023 |
13C magnetic resonance spectroscopy measurements with hyperpolarized [1‐13C] pyruvate can be used to detect the expression of transgenic pyruvate … P Dzien, SS Tee, MI Kettunen, SK Lyons, TJ Larkin, KN Timm, DE Hu, ... Magnetic resonance in medicine 76 (2), 391-401, 2016 | 7 | 2016 |
Rapid,‐insensitive, dual‐band quasi‐adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux JJ Miller, L Valkovič, M Kerr, KN Timm, WD Watson, JYC Lau, A Tyler, ... Magnetic resonance in medicine 85 (6), 2978-2991, 2021 | 6 | 2021 |