| Plasma viscosity regulates capillary perfusion during extreme hemodilution in hamster skinfold model AG Tsai, B Friesenecker, M McCarthy, H Sakai, M Intaglietta American Journal of Physiology-Heart and Circulatory Physiology 275 (6 …, 1998 | 294 | 1998 |
| Molecular dimensions of Hb-based O2 carriers determine constriction of resistance arteries and hypertension H Sakai, H Hara, M Yuasa, AG Tsai, S Takeoka, E Tsuchida, M Intaglietta American Journal of Physiology-Heart and Circulatory Physiology 279 (3 …, 2000 | 262 | 2000 |
| Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis F Ma, Y Ebihara, K Umeda, H Sakai, S Hanada, H Zhang, Y Zaike, ... Proceedings of the National Academy of Sciences 105 (35), 13087-13092, 2008 | 245 | 2008 |
| Artificial oxygen carriers, hemoglobin vesicles and albumin− hemes, based on bioconjugate chemistry E Tsuchida, K Sou, A Nakagawa, H Sakai, T Komatsu, K Kobayashi Bioconjugate chemistry 20 (8), 1419-1440, 2009 | 186 | 2009 |
| Surface modification of hemoglobin vesicles with poly (ethylene glycol) and effects on aggregation, viscosity, and blood flow during 90 exchange transfusion in anesthetized rats H Sakai, S Takeoka, SI Park, T Kose, H Nishide, Y Izumi, A Yoshizu, ... Bioconjugate chemistry 8 (1), 23-30, 1997 | 180 | 1997 |
| Poly (ethylene glycol)-conjugation and deoxygenation enable long-term preservation of hemoglobin-vesicles as oxygen carriers in a liquid state H Sakai, K Tomiyama, K Sou, S Takeoka, E Tsuchida Bioconjugate chemistry 11 (3), 425-432, 2000 | 170 | 2000 |
| Ex vivo large-scale generation of human red blood cells from cord blood CD34+ cells by co-culturing with macrophages A Fujimi, T Matsunaga, M Kobune, Y Kawano, T Nagaya, I Tanaka, ... International journal of hematology 87, 339-350, 2008 | 157 | 2008 |
| A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors A Niwa, T Heike, K Umeda, K Oshima, I Kato, H Sakai, H Suemori, ... PloS one 6 (7), e22261, 2011 | 154 | 2011 |
| Hemoglobin-vesicles suspended in recombinant human serum albumin for resuscitation from hemorrhagic shock in anesthetized rats H Sakai, Y Masada, H Horinouchi, M Yamamoto, E Ikeda, S Takeoka, ... Critical care medicine 32 (2), 539-545, 2004 | 135 | 2004 |
| Physical properties of hemoglobin vesicles as red cell substitutes H Sakai, K Hamada, S Takeoka, H Nishide, E Tsuchida Biotechnology progress 12 (1), 119-125, 1996 | 135 | 1996 |
| Hemoglobin-vesicles as oxygen carriers: influence on phagocytic activity and histopathological changes in reticuloendothelial system H Sakai, H Horinouchi, K Tomiyama, E Ikeda, S Takeoka, K Kobayashi, ... The American journal of pathology 159 (3), 1079-1088, 2001 | 133 | 2001 |
| Review of hemoglobin‐vesicles as artificial oxygen carriers H Sakai, K Sou, H Horinouchi, K Kobayashi, E Tsuchida Artificial organs 33 (2), 139-145, 2009 | 128 | 2009 |
| Microvascular responses to hemodilution with Hb vesicles as red blood cell substitutes: influence of O2 affinity H Sakai, AG Tsai, RJ Rohlfs, H Hara, S Takeoka, E Tsuchida, M Intaglietta American Journal of Physiology-Heart and Circulatory Physiology 276 (2 …, 1999 | 126 | 1999 |
| Haemoglobin‐vesicles as artificial oxygen carriers: present situation and future visions H Sakai, K Sou, H Horinouchi, K Kobayashi, E Tsuchida Journal of internal medicine 263 (1), 4-15, 2008 | 114 | 2008 |
| Purification of concentrated hemoglobin using organic solvent and heat treatment H Sakai, S Takeoka, H Yokohama, Y Seino, H Nishide, E Tsuchida Protein expression and purification 4 (6), 563-569, 1993 | 113 | 1993 |
| Synthesis and physicochemical characterization of a series of hemoglobin-based oxygen carriers: objective comparison between cellular and acellular types H Sakai, M Yuasa, H Onuma, S Takeoka, E Tsuchida Bioconjugate Chemistry 11 (1), 56-64, 2000 | 108 | 2000 |
| Encapsulation of concentrated hemoglobin solution in phospholipid vesicles retards the reaction with NO, but not CO, by intracellular diffusion barrier H Sakai, A Sato, K Masuda, S Takeoka, E Tsuchida Journal of Biological Chemistry 283 (3), 1508-1517, 2008 | 100 | 2008 |
| Systemic and microvascular responses to hemorrhagic shock and resuscitation with Hb vesicles H Sakai, S Takeoka, R Wettstein, AG Tsai, M Intaglietta, E Tsuchida American Journal of Physiology-Heart and Circulatory Physiology 283 (3 …, 2002 | 95 | 2002 |
| Characteristics of bovine hemoglobin as a potential source of hemoglobin-vesicles for an artificial oxygen carrier H Sakai, Y Masada, S Takeoka, E Tsuchida The journal of biochemistry 131 (4), 611-617, 2002 | 91 | 2002 |
| Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model H Sakai, H Horinouchi, Y Masada, S Takeoka, E Ikeda, M Takaori, ... Biomaterials 25 (18), 4317-4325, 2004 | 87 | 2004 |
