Common activation mechanism of class A GPCRs Q Zhou, D Yang, M Wu, Y Guo, W Guo, L Zhong, X Cai, A Dai, W Jang, ... Elife 8, e50279, 2019 | 416 | 2019 |
G protein-coupled receptors: structure-and function-based drug discovery D Yang, Q Zhou, V Labroska, S Qin, S Darbalaei, Y Wu, E Yuliantie, L Xie, ... Signal transduction and targeted therapy 6 (1), 7, 2021 | 357 | 2021 |
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators G Song, D Yang, Y Wang, C De Graaf, Q Zhou, S Jiang, K Liu, X Cai, ... Nature 546 (7657), 312-315, 2017 | 227 | 2017 |
Structural basis for apelin control of the human apelin receptor Y Ma, Y Yue, Y Ma, Q Zhang, Q Zhou, Y Song, Y Shen, X Li, X Ma, C Li, ... Structure 25 (6), 858-866. e4, 2017 | 137 | 2017 |
Molecular recognition of morphine and fentanyl by the human μ-opioid receptor Y Zhuang, Y Wang, B He, X He, XE Zhou, S Guo, Q Rao, J Yang, J Liu, ... Cell 185 (23), 4361-4375. e19, 2022 | 106 | 2022 |
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors F Zhao, Q Zhou, Z Cong, K Hang, X Zou, C Zhang, Y Chen, A Dai, A Liang, ... Nature communications 13 (1), 1057, 2022 | 74 | 2022 |
Structural basis for activation of the growth hormone-releasing hormone receptor F Zhou, H Zhang, Z Cong, LH Zhao, Q Zhou, C Mao, X Cheng, DD Shen, ... Nature communications 11 (1), 5205, 2020 | 53 | 2020 |
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor Z Cong, LN Chen, H Ma, Q Zhou, X Zou, C Ye, A Dai, Q Liu, W Huang, ... Nature communications 12 (1), 3763, 2021 | 49 | 2021 |
A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor W Sun, LN Chen, Q Zhou, LH Zhao, D Yang, H Zhang, Z Cong, DD Shen, ... Cell Research 30 (12), 1098-1108, 2020 | 49 | 2020 |
Structural perspective of class B1 GPCR signaling Z Cong, YL Liang, Q Zhou, S Darbalaei, F Zhao, W Feng, L Zhao, HE Xu, ... Trends in Pharmacological Sciences 43 (4), 321-334, 2022 | 43 | 2022 |
Structural basis of the diversity of adrenergic receptors L Qu, Q Zhou, Y Xu, Y Guo, X Chen, D Yao, GW Han, ZJ Liu, RC Stevens, ... Cell Reports 29 (10), 2929-2935. e4, 2019 | 40 | 2019 |
A general chemiluminescence strategy for measuring aptamer–target binding and target concentration S Li, D Chen, Q Zhou, W Wang, L Gao, J Jiang, H Liang, Y Liu, G Liang, ... Analytical chemistry 86 (11), 5559-5566, 2014 | 37 | 2014 |
GPCR allosteric modulator discovery Y Wu, J Tong, K Ding, Q Zhou, S Zhao Protein allostery in drug discovery, 225-251, 2019 | 36 | 2019 |
Molecular basis of ligand recognition and activation of human V2 vasopressin receptor F Zhou, C Ye, X Ma, W Yin, TI Croll, Q Zhou, X He, X Zhang, D Yang, ... Cell research 31 (8), 929-931, 2021 | 35 | 2021 |
High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening S Qin, M Meng, D Yang, W Bai, Y Lu, Y Peng, G Song, Y Wu, Q Zhou, ... Chemical science 9 (12), 3192-3199, 2018 | 35 | 2018 |
Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor F Zhao, C Zhang, Q Zhou, K Hang, X Zou, Y Chen, F Wu, Q Rao, A Dai, ... Elife 10, e68719, 2021 | 32 | 2021 |
Structures of the human cholecystokinin receptors bound to agonists and antagonists X Zhang, C He, M Wang, Q Zhou, D Yang, Y Zhu, W Feng, H Zhang, A Dai, ... Nature Chemical Biology 17 (12), 1230-1237, 2021 | 30 | 2021 |
Apj+ vessels drive tumor growth and represent a tractable therapeutic target H Zhao, X Tian, L He, Y Li, W Pu, Q Liu, J Tang, J Wu, X Cheng, Y Liu, ... Cell reports 25 (5), 1241-1254. e5, 2018 | 30 | 2018 |
Searching the sequence space for potent aptamers using SELEX in silico Q Zhou, X Xia, Z Luo, H Liang, E Shakhnovich Journal of chemical theory and computation 11 (12), 5939-5946, 2015 | 30 | 2015 |
Cryo-EM structures of PI3Kα reveal conformational changes during inhibition and activation X Liu, S Yang, JR Hart, Y Xu, X Zou, H Zhang, Q Zhou, T Xia, Y Zhang, ... Proceedings of the National Academy of Sciences 118 (45), e2109327118, 2021 | 24 | 2021 |