| The extremely conserved C-terminal region of Reelin is not necessary for secretion but is required for efficient activation of downstream signaling Y Nakano, T Kohno, T Hibi, S Kohno, A Baba, K Mikoshiba, K Nakajima, ... Journal of Biological Chemistry 282 (28), 20544-20552, 2007 | 99 | 2007 |
| Mechanism and significance of specific proteolytic cleavage of Reelin S Kohno, T Kohno, Y Nakano, K Suzuki, M Ishii, H Tagami, A Baba, ... Biochemical and biophysical research communications 380 (1), 93-97, 2009 | 80 | 2009 |
| Cleavage within Reelin repeat 3 regulates the duration and range of the signaling activity of Reelin protein M Koie, K Okumura, A Hisanaga, T Kamei, K Sasaki, M Deng, A Baba, ... Journal of Biological Chemistry 289 (18), 12922-12930, 2014 | 78 | 2014 |
| Importance of Reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis T Kohno, T Honda, K Kubo, Y Nakano, A Tsuchiya, T Murakami, H Banno, ... Journal of Neuroscience 35 (11), 4776-4787, 2015 | 77 | 2015 |
| Secreted metalloproteinase ADAMTS-3 inactivates Reelin H Ogino, A Hisanaga, T Kohno, Y Kondo, K Okumura, T Kamei, T Sato, ... Journal of Neuroscience 37 (12), 3181-3191, 2017 | 68 | 2017 |
| A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an isoform-dependent manner A Hisanaga, S Morishita, K Suzuki, K Sasaki, M Koie, T Kohno, M Hattori FEBS letters 586 (19), 3349-3353, 2012 | 67 | 2012 |
| Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage Y Sato, D Kobayashi, T Kohno, Y Kidani, J Prox, C Becker-Pauly, ... The journal of biochemistry 159 (3), 305-312, 2016 | 51 | 2016 |
| Functional importance of covalent homodimer of reelin protein linked via its central region N Yasui, Y Kitago, A Beppu, T Kohno, S Morishita, H Gomi, M Nagae, ... Journal of Biological Chemistry 286 (40), 35247-35256, 2011 | 46 | 2011 |
| Mice that lack the C-terminal region of Reelin exhibit behavioral abnormalities related to neuropsychiatric disorders K Sakai, H Shoji, T Kohno, T Miyakawa, M Hattori Scientific reports 6 (1), 28636, 2016 | 44 | 2016 |
| Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia A Sobue, I Kushima, T Nagai, W Shan, T Kohno, B Aleksic, Y Aoyama, ... Scientific reports 8 (1), 13046, 2018 | 42 | 2018 |
| Reelin supplementation into the hippocampus rescues abnormal behavior in a mouse model of neurodevelopmental disorders D Ibi, G Nakasai, N Koide, M Sawahata, T Kohno, R Takaba, T Nagai, ... Frontiers in cellular neuroscience 14, 285, 2020 | 34 | 2020 |
| CUB and Sushi multiple domains 3 regulates dendrite development T Mizukami, T Kohno, M Hattori Neuroscience research 110, 11-17, 2016 | 31 | 2016 |
| A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum Y Yamakage, M Kato, A Hongo, H Ogino, K Ishii, T Ishizuka, T Kamei, ... Molecular and Cellular Neuroscience 100, 103401, 2019 | 30 | 2019 |
| C‐terminal region‐dependent change of antibody‐binding to the Eighth Reelin repeat reflects the signaling activity of Reelin T Kohno, Y Nakano, N Kitoh, H Yagi, K Kato, A Baba, M Hattori Journal of neuroscience research 87 (14), 3043-3053, 2009 | 29 | 2009 |
| Regulation of Reelin functions by specific proteolytic processing in the brain M Hattori, T Kohno The journal of biochemistry 169 (5), 511-516, 2021 | 23 | 2021 |
| Reelin-Nrp1 interaction regulates neocortical dendrite development in a context-specific manner T Kohno, K Ishii, Y Hirota, T Honda, M Makino, T Kawasaki, K Nakajima, ... Journal of Neuroscience 40 (43), 8248-8261, 2020 | 22 | 2020 |
| Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice E Okugawa, H Ogino, T Shigenobu, Y Yamakage, H Tsuiji, H Oishi, ... Scientific reports 10 (1), 4471, 2020 | 21 | 2020 |
| Semaphorin 6A–Plexin A2/A4 Interactions with Radial Glia Regulate Migration Termination of Superficial Layer Cortical Neurons Y Hatanaka, T Kawasaki, T Abe, G Shioi, T Kohno, M Hattori, ... IScience 21, 359-374, 2019 | 21 | 2019 |
| Differential localization of sphingomyelin synthase isoforms in neurons regulates sphingomyelin cluster formation Y Kidani, K Ohshima, H Sakai, T Kohno, A Baba, M Hattori Biochemical and Biophysical Research Communications 417 (3), 1014-1017, 2012 | 19 | 2012 |
| Microinjection of Reelin into the mPFC prevents MK-801-induced recognition memory impairment in mice M Sawahata, H Asano, T Nagai, N Ito, T Kohno, T Nabeshima, M Hattori, ... Pharmacological Research 173, 105832, 2021 | 15 | 2021 |
