关注
Bryan Ngo
Bryan Ngo
Altos Labs (Previously, Weill Cornell Medicine, Memorial Sloan Kettering, Rockefeller University)
在 Med.cornell.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
Chromosomal instability drives metastasis through a cytosolic DNA response
SF Bakhoum, B Ngo, AM Laughney, JA Cavallo, CJ Murphy, P Ly, P Shah, ...
Nature 553 (7689), 467-472, 2018
12322018
Targeting cancer vulnerabilities with high-dose vitamin C
B Ngo, JM Van Riper, LC Cantley, J Yun
Nature Reviews Cancer 19 (5), 271-282, 2019
3472019
Limited environmental serine and glycine confer brain metastasis sensitivity to PHGDH inhibition
B Ngo, E Kim, V Osorio-Vasquez, S Doll, S Bustraan, RJ Liang, A Luengo, ...
Cancer discovery 10 (9), 1352-1373, 2020
1762020
Targeting tumor suppressor networks for cancer therapeutics
X Emily Guo, B Ngo, A Sandaldjian Modrek, WH Lee
Current drug targets 15 (1), 2-16, 2014
1232014
Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution
S Venkatesan, M Angelova, C Puttick, H Zhai, DR Caswell, WT Lu, ...
Cancer discovery 11 (10), 2456-2473, 2021
902021
Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint
R Wei, B Ngo, G Wu, WH Lee
Molecular biology of the cell 22 (19), 3584-3594, 2011
842011
Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism
CM Hu, J Zhu, XE Guo, W Chen, XL Qiu, B Ngo, R Chien, YV Wang, ...
Oncogene 34 (10), 1220-1230, 2015
532015
Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly
CY Tsai, B Ngo, A Tapadia, PH Hsu, G Wu, WH Lee
Journal of Biological Chemistry 286 (34), 30097-30106, 2011
442011
Oncologic impact of micrometastases or isolated tumor cells in sentinel lymph nodes of patients with endometrial cancer: a meta-analysis
NR Gómez-Hidalgo, PT Ramirez, B Ngo, S Pérez-Hoyos, N Coreas, ...
Clinical and Translational Oncology 22, 1272-1279, 2020
372020
Hec1 contributes to mitotic centrosomal microtubule growth for proper spindle assembly through interaction with Hice1
G Wu, R Wei, E Cheng, B Ngo, WH Lee
Molecular biology of the cell 20 (22), 4686-4695, 2009
212009
GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase
RJ Liang, S Taylor, N Nahiyaan, J Song, CJ Murphy, E Dantas, S Cheng, ...
Cancer & Metabolism 9, 1-13, 2021
192021
LKB1-dependent regulation of TPI1 creates a divergent metabolic liability between human and mouse lung adenocarcinoma
BD Stein, JR Ferrarone, EE Gardner, JW Chang, D Wu, PE Hollstein, ...
Cancer discovery 13 (4), 1002-1025, 2023
62023
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation
M Rogava, TJ Aprati, WY Chi, JC Melms, C Hug, SH Davis, EM Earlie, ...
Nature Cancer, 1-15, 2024
32024
Complementary interhelical interactions between three buried Glu-Lys pairs within three heptad repeats are essential for Hec1-Nuf2 heterodimerization and mitotic progression
B Ngo, CM Hu, XE Guo, B Ngo, R Wei, J Zhu, WH Lee
Journal of Biological Chemistry 288 (48), 34403-34413, 2013
32013
Non-conserved metabolic regulation by LKB1 distinguishes human and mouse lung adenocarcinoma
BD Stein, JR Ferrarone, EE Gardner, JW Chang, D Wu, Q Chen, ...
bioRxiv, 2021.10. 01.462764, 2021
12021
Targeting chromosomal instability and downstream cytosolic dna signaling for cancer treatment
LC Cantley, B Ngo, SF Bakhoum
US Patent App. 18/299,558, 2024
2024
Targeting chromosomal instability and downstream cytosolic DNA signaling for cancer treatment
LC Cantley, B Ngo, SF Bakhoum
US Patent 11,821,042, 2023
2023
A genetic-metabolic circuit of liver-specific metastatic organotropism
M Rogava, TJ Aprati, WY Chen, J Melms, C Hug, AD Amin, B Ngo, M Lee, ...
Cancer Research 83 (7_Supplement), 3514-3514, 2023
2023
Protein State‐Dependent Chemical Biology
KA Scott, TL Zhang, SY Xi, B Ngo, EV Vinogradova
Israel Journal of Chemistry 63 (3-4), e202200101, 2023
2023
A genetic-metabolic axis of metastatic liver organotropism
M Rogava, JC Melms, S Davis, C Hug, B Ngo, MJ Lee, P Ho, AD Amin, ...
Cancer Research 82 (12_Supplement), 981-981, 2022
2022
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