Cancer-associated IDH1 mutations produce 2-hydroxyglutarate L Dang, DW White, S Gross, BD Bennett, MA Bittinger, EM Driggers, ... Nature 462 (7274), 739-744, 2009 | 4631 | 2009 |
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2-hydroxyglutarate PS Ward, J Patel, DR Wise, O Abdel-Wahab, BD Bennett, HA Coller, ... Cancer cell 17 (3), 225-234, 2010 | 2300 | 2010 |
Autophagy and metabolism JD Rabinowitz, E White Science 330 (6009), 1344-1348, 2010 | 2223 | 2010 |
Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli BD Bennett, EH Kimball, M Gao, R Osterhout, SJ Van Dien, ... Nature chemical biology 5 (8), 593-599, 2009 | 2002 | 2009 |
One-carbon metabolism in health and disease GS Ducker, JD Rabinowitz Cell metabolism 25 (1), 27-42, 2017 | 1627 | 2017 |
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells C Commisso, SM Davidson, RG Soydaner-Azeloglu, SJ Parker, ... Nature 497 (7451), 633-637, 2013 | 1602 | 2013 |
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis JY Guo, HY Chen, R Mathew, J Fan, AM Strohecker, G Karsli-Uzunbas, ... Genes & development 25 (5), 460-470, 2011 | 1450 | 2011 |
Glucose feeds the TCA cycle via circulating lactate S Hui, JM Ghergurovich, RJ Morscher, C Jang, X Teng, W Lu, LA Esparza, ... Nature 551 (7678), 115-118, 2017 | 1338 | 2017 |
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway A Stincone, A Prigione, T Cramer, MMC Wamelink, K Campbell, ... Biological Reviews 90 (3), 927-963, 2015 | 1263 | 2015 |
Quantitative flux analysis reveals folate-dependent NADPH production J Fan, J Ye, JJ Kamphorst, T Shlomi, CB Thompson, JD Rabinowitz Nature 510 (7504), 298-302, 2014 | 1057 | 2014 |
Mitochondria and cancer WX Zong, JD Rabinowitz, E White Molecular cell 61 (5), 667-676, 2016 | 1055 | 2016 |
Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein JJ Kamphorst, M Nofal, C Commisso, SR Hackett, W Lu, E Grabocka, ... Cancer research 75 (3), 544-553, 2015 | 792 | 2015 |
Evidence for an alternative glycolytic pathway in rapidly proliferating cells MG Vander Heiden, JW Locasale, KD Swanson, H Sharfi, GJ Heffron, ... Science 329 (5998), 1492-1499, 2010 | 739 | 2010 |
Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry SU Bajad, W Lu, EH Kimball, J Yuan, C Peterson, JD Rabinowitz Journal of chromatography A 1125 (1), 76-88, 2006 | 715 | 2006 |
Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy J Munger, BD Bennett, A Parikh, XJ Feng, J McArdle, HA Rabitz, T Shenk, ... Nature biotechnology 26 (10), 1179-1186, 2008 | 711 | 2008 |
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids JJ Kamphorst, JR Cross, J Fan, E De Stanchina, R Mathew, EP White, ... Proceedings of the National Academy of Sciences 110 (22), 8882-8887, 2013 | 691 | 2013 |
Metabolomics and isotope tracing C Jang, L Chen, JD Rabinowitz Cell 173 (4), 822-837, 2018 | 689 | 2018 |
Metabolomic analysis and visualization engine for LC− MS data E Melamud, L Vastag, JD Rabinowitz Analytical chemistry 82 (23), 9818-9826, 2010 | 651 | 2010 |
A roadmap for interpreting 13C metabolite labeling patterns from cells JM Buescher, MR Antoniewicz, LG Boros, SC Burgess, H Brunengraber, ... Current opinion in biotechnology 34, 189-201, 2015 | 619 | 2015 |
Analytical strategies for LC–MS-based targeted metabolomics W Lu, BD Bennett, JD Rabinowitz Journal of chromatography B 871 (2), 236-242, 2008 | 610 | 2008 |