| The nuclear receptor superfamily: A structural perspective ER Weikum, X Liu, EA Ortlund Protein Science 27 (11), 1876-1892, 2018 | 434 | 2018 |
| Characterization of a linked Jumonji domain of the KDM5/JARID1 family of histone H3 lysine 4 demethylases JR Horton, A Engstrom, EL Zoeller, X Liu, JR Shanks, X Zhang, MA Johns, ... Journal of Biological Chemistry 291 (6), 2631-2646, 2016 | 110 | 2016 |
| Structural basis for KDM5A histone lysine demethylase inhibition by diverse compounds JR Horton, X Liu, M Gale, L Wu, JR Shanks, X Zhang, PJ Webber, ... Cell chemical biology 23 (7), 769-781, 2016 | 97 | 2016 |
| Emerging themes in PDZ domain signaling: structure, function, and inhibition X Liu, EJ Fuentes International review of cell and molecular biology 343, 129-218, 2019 | 67 | 2019 |
| The Tiam1 PDZ domain couples to Syndecan1 and promotes cell–matrix adhesion TR Shepherd, SM Klaus, X Liu, S Ramaswamy, KA DeMali, EJ Fuentes Journal of molecular biology 398 (5), 730-746, 2010 | 67 | 2010 |
| Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment X Liu, Y Wang, JS Gutierrez, JM Damsker, K Nagaraju, EP Hoffman, ... Proceedings of the National Academy of Sciences 117 (39), 24285-24293, 2020 | 50 | 2020 |
| ZNF830 mediates cancer chemoresistance through promoting homologous-recombination repair G Chen, J Chen, Y Qiao, Y Shi, W Liu, Q Zeng, H Xie, X Shi, Y Sun, X Liu, ... Nucleic acids research 46 (3), 1266-1279, 2018 | 46 | 2018 |
| The structure of the Tiam1 PDZ domain/phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics X Liu, TR Shepherd, AM Murray, Z Xu, EJ Fuentes Structure 21 (3), 342-354, 2013 | 46 | 2013 |
| Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation F Frank, X Liu, EA Ortlund Proceedings of the National Academy of Sciences 118 (30), e2024685118, 2021 | 39 | 2021 |
| Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests F Frank, MM Keen, A Rao, L Bassit, X Liu, HB Bowers, AB Patel, ML Cato, ... Cell 185 (19), 3603-3616. e13, 2022 | 34 | 2022 |
| Structure-based engineering of irreversible inhibitors against histone lysine demethylase KDM5A JR Horton, CB Woodcock, Q Chen, X Liu, X Zhang, J Shanks, G Rai, ... Journal of medicinal chemistry 61 (23), 10588-10601, 2018 | 33 | 2018 |
| First high-resolution crystal structures of the glucocorticoid receptor ligand-binding domain–peroxisome proliferator-activated γ coactivator 1-α complex with endogenous and … X Liu, Y Wang, EA Ortlund Molecular Pharmacology 96 (4), 408-417, 2019 | 31 | 2019 |
| Distinct roles for conformational dynamics in protein-ligand interactions X Liu, DC Speckhard, TR Shepherd, YJ Sun, SR Hengel, L Yu, CA Fowler, ... Structure 24 (12), 2053-2066, 2016 | 30 | 2016 |
| Structural insights into glucocorticoid receptor function F Frank, EA Ortlund, X Liu Biochemical Society Transactions 49 (5), 2333-2343, 2021 | 23 | 2021 |
| Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling NE Bruno, JC Nwachukwu, S Srinivasan, CC Nettles, T Izard, Z Jin, ... Nature Chemical Biology 17 (3), 307-316, 2021 | 14 | 2021 |
| Insights into the action of inhibitor enantiomers against histone lysine demethylase 5A JR Horton, X Liu, L Wu, K Zhang, J Shanks, X Zhang, G Rai, BT Mott, ... Journal of medicinal chemistry 61 (7), 3193-3208, 2018 | 13 | 2018 |
| SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks P Kapoor-Vazirani, SK Rath, X Liu, Z Shu, NE Bowen, Y Chen, ... Nature communications 13 (1), 6707, 2022 | 12 | 2022 |
| Proline-rich acidic protein 1 (PRAP1) protects the gastrointestinal epithelium from irradiation-induced apoptosis AA Wolfarth, X Liu, TM Darby, DJ Boyer, JB Spizman, JA Owens, ... Cellular and Molecular Gastroenterology and Hepatology 10 (4), 713-727, 2020 | 11 | 2020 |
| Conformational dynamics and cooperativity drive the specificity of a protein-ligand interaction X Liu, LC Golden, JA Lopez, TR Shepherd, L Yu, EJ Fuentes Biophysical journal 116 (12), 2314-2330, 2019 | 11 | 2019 |
| A phospholipid mimetic targeting LRH-1 ameliorates colitis SG Mays, EH D’Agostino, AR Flynn, X Huang, G Wang, X Liu, EJ Millings, ... Cell Chemical Biology 29 (7), 1174-1186. e7, 2022 | 9 | 2022 |
