Drug target miRNAs: chances and challenges MF Schmidt Trends in biotechnology 32 (11), 578-585, 2014 | 156 | 2014 |
Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease L Zhu, S George, MF Schmidt, SI Al-Gharabli, J Rademann, R Hilgenfeld Antiviral research 92 (2), 204-212, 2011 | 135 | 2011 |
Sensitized detection of inhibitory fragments and iterative development of non‐peptidic protease inhibitors by dynamic ligation screening MF Schmidt, A Isidro‐Llobet, M Lisurek, A El‐Dahshan, J Tan, ... Angewandte Chemie International Edition 47 (17), 3275-3278, 2008 | 87 | 2008 |
An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS‐CoV Mpro) inhibitors SI Al‐Gharabli, STA Shah, S Weik, MF Schmidt, JR Mesters, D Kuhn, ... ChemBioChem 7 (7), 1048-1055, 2006 | 77 | 2006 |
Dynamic template-assisted strategies in fragment-based drug discovery MF Schmidt, J Rademann Trends in biotechnology 27 (9), 512-521, 2009 | 68 | 2009 |
Design, synthesis, and qualitative structure–activity evaluations of novel β-Secretase inhibitors as potential Alzheimer’s drug leads TH Al-Tel, MH Semreen, RA Al-Qawasmeh, MF Schmidt, R El-Awadi, ... Journal of medicinal chemistry 54 (24), 8373-8385, 2011 | 60 | 2011 |
Selective identification of cooperatively binding fragments in a high‐throughput ligation assay enables development of a picomolar caspase‐3 inhibitor MF Schmidt, A El‐Dahshan, S Keller, J Rademann Angewandte Chemie International Edition 48 (34), 6346-6349, 2009 | 55 | 2009 |
Rational design and synthesis of potent dibenzazepine motifs as β-secretase inhibitors TH Al-Tel, RA Al-Qawasmeh, MF Schmidt, A Al-Aboudi, SN Rao, SS Sabri, ... Journal of medicinal chemistry 52 (20), 6484-6488, 2009 | 46 | 2009 |
MicroRNA-specific argonaute 2 protein inhibitors MF Schmidt, O Korb, C Abell ACS chemical biology 8 (10), 2122-2126, 2013 | 43 | 2013 |
Dynamic Substrate Enhancement for the Identification of Specific, Second‐Site‐Binding Fragments Targeting a Set of Protein Tyrosine Phosphatases MF Schmidt, MR Groves, J Rademann ChemBioChem 12 (17), 2640-2646, 2011 | 34 | 2011 |
miRNA targeting drugs: the next blockbusters? MF Schmidt Drug Target miRNA: Methods and Protocols, 3-22, 2017 | 28 | 2017 |
Sensibilisierte Detektion inhibitorischer Fragmente und iterative Entwicklung nicht‐peptidischer Proteaseinhibitoren durch dynamisches Ligationsscreening MF Schmidt, A Isidro‐Llobet, M Lisurek, A El‐Dahshan, J Tan, ... Angewandte Chemie 120 (17), 3319-3323, 2008 | 28 | 2008 |
Selektive Detektion kooperativ bindender Fragmente in einem Hochdurchsatz-Ligationsassay zur Entwicklung eines pikomolaren Caspase-3-Inhibitors MF Schmidt, A El-Dahshan, S Keller, J Rademann Angew. Chem 121, 6464-6467, 2009 | 20 | 2009 |
Discovery of Schaeffer's acid analogues as lead structures of mycobacterium tuberculosis type II dehydroquinase using a rational drug design approach. MF Schmidt, O Korb, NI Howard, MV Dias, TL Blundell, C Abell ChemMedChem 8 (1), 54-58, 2012 | 17 | 2012 |
Design and Structural Analysis of Aromatic Inhibitors of Type II Dehydroquinase from Mycobacterium tuberculosis NI Howard, MVB Dias, F Peyrot, L Chen, MF Schmidt, TL Blundell, C Abell ChemMedChem 10 (1), 116-133, 2015 | 13 | 2015 |
Interaction-based feature selection algorithm outperforms polygenic risk score in predicting Parkinson’s disease status JL Cope, HA Baukmann, JE Klinger, CNJ Ravarani, EP Böttinger, ... Frontiers in genetics 12, 744557, 2021 | 7 | 2021 |
Critically ill COVID-19 status associated trait genetics reveals CDK6 inhibitors as potential treatment J Klinger, C Ravarani, C Bannard, M Lamparter, A Schwinges, J Cope, ... | 3 | 2021 |
Neutrophils cause critical illness in COVID-19 and reveal CDK6 inhibitors as potential treatment HA Baukmann, JL Cope, CNJ Ravarani, C Bannard, MRJ Lamparter, ... MedRxiv, 2021.05. 18.21256584, 2021 | 2 | 2021 |
CHEMISCHE BIOLOGIE: und wirkstoffentwicklung MF Schmidt Springer Spektrum, 2020 | 2 | 2020 |
Drug Target miRNA: methods and protocols MF Schmidt Humana Press, 2017 | 2 | 2017 |