| Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors GD Demetri, M Von Mehren, CD Blanke, AD Van den Abbeele, ... New England Journal of Medicine 347 (7), 472-480, 2002 | 5500 | 2002 |
| Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer KP Olive, MA Jacobetz, CJ Davidson, A Gopinathan, D McIntyre, ... Science 324 (5933), 1457-1461, 2009 | 3537 | 2009 |
| Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse SR Hingorani, EF Petricoin, A Maitra, V Rajapakse, C King, MA Jacobetz, ... Cancer cell 4 (6), 437-450, 2003 | 2801 | 2003 |
| Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor H Joensuu, PJ Roberts, M Sarlomo-Rikala, LC Andersson, ... New England Journal of Medicine 344 (14), 1052-1056, 2001 | 2731 | 2001 |
| Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice SR Hingorani, L Wang, AS Multani, C Combs, TB Deramaudt, RH Hruban, ... Cancer cell 7 (5), 469-483, 2005 | 2713 | 2005 |
| A framework for advancing our understanding of cancer-associated fibroblasts E Sahai, I Astsaturov, E Cukierman, DG DeNardo, M Egeblad, RM Evans, ... Nature Reviews Cancer 20 (3), 174-186, 2020 | 2571 | 2020 |
| Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis GM DeNicola, FA Karreth, TJ Humpton, A Gopinathan, C Wei, K Frese, ... Nature 475 (7354), 106-109, 2011 | 2292 | 2011 |
| Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes AV Biankin, N Waddell, KS Kassahn, MC Gingras, LB Muthuswamy, ... Nature 491 (7424), 399-405, 2012 | 2201 | 2012 |
| Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras EL Jackson, N Willis, K Mercer, RT Bronson, D Crowley, R Montoya, ... Genes & development 15 (24), 3243-3248, 2001 | 2170 | 2001 |
| Restoration of p53 function leads to tumour regression in vivo A Ventura, DG Kirsch, ME McLaughlin, DA Tuveson, J Grimm, L Lintault, ... Nature 445 (7128), 661-665, 2007 | 2125 | 2007 |
| Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer D Öhlund, A Handly-Santana, G Biffi, E Elyada, AS Almeida, ... Journal of Experimental Medicine 214 (3), 579-596, 2017 | 1988 | 2017 |
| Organoid models of human and mouse ductal pancreatic cancer SF Boj, CI Hwang, LA Baker, IIC Chio, DD Engle, V Corbo, M Jager, ... Cell 160 (1), 324-338, 2015 | 1948 | 2015 |
| Pancreatic cancer J Kleeff, M Korc, M Apte, C La Vecchia, CD Johnson, AV Biankin, ... Nature reviews Disease primers 2 (1), 1-22, 2016 | 1890 | 2016 |
| Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer C Feig, JO Jones, M Kraman, RJB Wells, A Deonarine, DS Chan, ... Proceedings of the National Academy of Sciences 110 (50), 20212-20217, 2013 | 1829 | 2013 |
| Transcriptional regulation by Nrf2 C Tonelli, IIC Chio, DA Tuveson Antioxidants & redox signaling 29 (17), 1727-1745, 2018 | 1722 | 2018 |
| Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome KP Olive, DA Tuveson, ZC Ruhe, B Yin, NA Willis, RT Bronson, D Crowley, ... Cell 119 (6), 847-860, 2004 | 1490 | 2004 |
| The pancreas cancer microenvironment C Feig, A Gopinathan, A Neesse, DS Chan, N Cook, DA Tuveson Clinical cancer research 18 (16), 4266-4276, 2012 | 1405 | 2012 |
| Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma I Varela, P Tarpey, K Raine, D Huang, CK Ong, P Stephens, H Davies, ... Nature 469 (7331), 539-542, 2011 | 1401 | 2011 |
| Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts E Elyada, M Bolisetty, P Laise, WF Flynn, ET Courtois, RA Burkhart, ... Cancer discovery 9 (8), 1102-1123, 2019 | 1381 | 2019 |
| Somatic activation of the K-ras oncogene causes early onset lung cancer in mice L Johnson, K Mercer, D Greenbaum, RT Bronson, D Crowley, ... Nature 410 (6832), 1111-1116, 2001 | 1354 | 2001 |
