| Discovery of bioactive molecules from CuAAC click-chemistry-based combinatorial libraries X Wang, B Huang, X Liu, P Zhan Drug Discovery Today 21 (1), 118-132, 2016 | 185 | 2016 |
| Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved … D Kang, Z Fang, Z Li, B Huang, H Zhang, X Lu, H Xu, Z Zhou, X Ding, ... Journal of medicinal chemistry 59 (17), 7991-8007, 2016 | 121 | 2016 |
| Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency … D Kang, Z Fang, B Huang, X Lu, H Zhang, H Xu, Z Huo, Z Zhou, Z Yu, ... Journal of medicinal chemistry 60 (10), 4424-4443, 2017 | 96 | 2017 |
| Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: Optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and … B Huang, C Li, W Chen, T Liu, M Yu, L Fu, Y Sun, H Liu, E De Clercq, ... European journal of medicinal chemistry 92, 754-765, 2015 | 96 | 2015 |
| Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1, 4-disubstituted 1, 2, 3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and … Y Tian, Z Liu, J Liu, B Huang, D Kang, H Zhang, E De Clercq, ... European journal of medicinal chemistry 151, 339-350, 2018 | 86 | 2018 |
| Inhibitors of influenza virus polymerase acidic (PA) endonuclease: contemporary developments and perspectives H Ju, J Zhang, B Huang, D Kang, B Huang, X Liu, P Zhan Journal of Medicinal Chemistry 60 (9), 3533-3551, 2017 | 84 | 2017 |
| Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against … B Huang, W Chen, T Zhao, Z Li, X Jiang, T Ginex, D Vílchez, FJ Luque, ... Journal of medicinal chemistry 62 (4), 2083-2098, 2019 | 71 | 2019 |
| Design, synthesis and biological evaluation of tacrine-1, 2, 3-triazole derivatives as potent cholinesterase inhibitors G Wu, Y Gao, D Kang, B Huang, Z Huo, H Liu, V Poongavanam, P Zhan, ... MedChemComm 9 (1), 149-159, 2018 | 65 | 2018 |
| Optimization of N-substituted oseltamivir derivatives as potent inhibitors of group-1 and-2 influenza A neuraminidases, including a drug-resistant variant J Zhang, V Poongavanam, D Kang, C Bertagnin, H Lu, X Kong, H Ju, X Lu, ... Journal of Medicinal Chemistry 61 (14), 6379-6397, 2018 | 54 | 2018 |
| First discovery of novel 3-hydroxy-quinazoline-2, 4 (1H, 3H)-diones as specific anti-vaccinia and adenovirus agents via ‘privileged scaffold’refining approach D Kang, H Zhang, Z Zhou, B Huang, L Naesens, P Zhan, X Liu Bioorganic & Medicinal Chemistry Letters 26 (21), 5182-5186, 2016 | 48 | 2016 |
| Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene [3, 2-d] pyrimidine derivatives as potent HIV-1 NNRTIs D Kang, D Feng, T Ginex, J Zou, F Wei, T Zhao, B Huang, Y Sun, S Desta, ... Acta Pharmaceutica Sinica B 10 (5), 878-894, 2020 | 47 | 2020 |
| Medicinal chemistry insights in the discovery of novel LSD1 inhibitors X Wang, B Huang, T Suzuki, X Liu, P Zhan Epigenomics 7 (8), 1379-1396, 2015 | 45 | 2015 |
| Discovery of non-peptide small molecular CXCR4 antagonists as anti-HIV agents: Recent advances and future opportunities H Zhang, D Kang, B Huang, N Liu, F Zhao, P Zhan, X Liu European journal of medicinal chemistry 114, 65-78, 2016 | 44 | 2016 |
| Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: Design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines B Huang, X Liang, C Li, W Chen, T Liu, X Li, Y Sun, L Fu, H Liu, ... European journal of medicinal chemistry 93, 330-337, 2015 | 44 | 2015 |
| Teaching an old dog new tricks: Drug discovery by repositioning natural products and their derivatives B Huang, Y Zhang Drug discovery today 27 (7), 1936-1944, 2022 | 43 | 2022 |
| Design of bivalent ligands targeting putative GPCR dimers B Huang, CMS Onge, H Ma, Y Zhang Drug Discovery Today 26 (1), 189-199, 2021 | 41 | 2021 |
| Discovery of small molecular inhibitors targeting HIV-1 gp120–CD4 interaction drived from BMS-378806 T Liu, B Huang, P Zhan, E De Clercq, X Liu European Journal of Medicinal Chemistry 86, 481-490, 2014 | 39 | 2014 |
| Further exploring solvent-exposed tolerant regions of allosteric binding pocket for novel HIV-1 NNRTIs discovery D Kang, Z Wang, H Zhang, G Wu, T Zhao, Z Zhou, Z Huo, B Huang, ... ACS medicinal chemistry letters 9 (4), 370-375, 2018 | 34 | 2018 |
| Structural optimization of pyridine-type DAPY derivatives to exploit the tolerant regions of the NNRTI binding pocket W Chen, P Zhan, D Daelemans, J Yang, B Huang, E De Clercq, ... European Journal of Medicinal Chemistry 121, 352-363, 2016 | 31 | 2016 |
| Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket J Yang, W Chen, D Kang, X Lu, X Li, Z Liu, B Huang, D Daelemans, ... European Journal of Medicinal Chemistry 109, 294-304, 2016 | 30 | 2016 |
