Pembrolizumab versus ipilimumab in advanced melanoma C Robert, J Schachter, GV Long, A Arance, JJ Grob, L Mortier, A Daud, ... New England Journal of Medicine 372 (26), 2521-2532, 2015 | 5897 | 2015 |
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial A Hauschild, JJ Grob, LV Demidov, T Jouary, R Gutzmer, M Millward, ... The Lancet 380 (9839), 358-365, 2012 | 3507 | 2012 |
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma EM Van Allen, D Miao, B Schilling, SA Shukla, C Blank, L Zimmer, ... Science 350 (6257), 207-211, 2015 | 2738 | 2015 |
Adjuvant pembrolizumab versus placebo in resected stage III melanoma AMM Eggermont, CU Blank, M Mandala, GV Long, V Atkinson, S Dalle, ... New England Journal of Medicine 378 (19), 1789-1801, 2018 | 1783 | 2018 |
Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial A Ribas, I Puzanov, R Dummer, D Schadendorf, O Hamid, C Robert, ... The lancet oncology 16 (8), 908-918, 2015 | 1768 | 2015 |
B cells and tertiary lymphoid structures promote immunotherapy response BA Helmink, SM Reddy, J Gao, S Zhang, R Basar, R Thakur, K Yizhak, ... Nature 577 (7791), 549-555, 2020 | 1735 | 2020 |
The human tumor microbiome is composed of tumor type–specific intracellular bacteria D Nejman, I Livyatan, G Fuks, N Gavert, Y Zwang, LT Geller, ... Science 368 (6494), 973-980, 2020 | 1377 | 2020 |
LDHA-associated lactic acid production blunts tumor immunosurveillance by T and NK cells A Brand, K Singer, GE Koehl, M Kolitzus, G Schoenhammer, A Thiel, ... Cell metabolism 24 (5), 657-671, 2016 | 1367 | 2016 |
Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006) J Schachter, A Ribas, GV Long, A Arance, JJ Grob, L Mortier, A Daud, ... The Lancet 390 (10105), 1853-1862, 2017 | 1294 | 2017 |
Defining ‘T cell exhaustion’ CU Blank, WN Haining, W Held, PG Hogan, A Kallies, E Lugli, RC Lynn, ... Nature Reviews Immunology 19 (11), 665-674, 2019 | 1103 | 2019 |
Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study C Robert, A Ribas, J Schachter, A Arance, JJ Grob, L Mortier, A Daud, ... The Lancet Oncology 20 (9), 1239-1251, 2019 | 1036 | 2019 |
PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells C Blank, I Brown, AC Peterson, M Spiotto, Y Iwai, T Honjo, TF Gajewski Cancer research 64 (3), 1140-1145, 2004 | 1028 | 2004 |
Reversible and adaptive resistance to BRAF (V600E) inhibition in melanoma C Sun, L Wang, S Huang, GJJE Heynen, A Prahallad, C Robert, ... Nature 508 (7494), 118-122, 2014 | 887 | 2014 |
Dysfunctional CD8 T cells form a proliferative, dynamically regulated compartment within human melanoma H Li, AM van der Leun, I Yofe, Y Lubling, D Gelbard-Solodkin, ... Cell 176 (4), 775-789. e18, 2019 | 869 | 2019 |
Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy C Blank, TF Gajewski, A Mackensen Cancer Immunology, Immunotherapy 54, 307-314, 2005 | 820 | 2005 |
The “cancer immunogram” CU Blank, JB Haanen, A Ribas, TN Schumacher Science 352 (6286), 658-660, 2016 | 791 | 2016 |
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study PA Ascierto, D Schadendorf, C Berking, SS Agarwala, CML van Herpen, ... The lancet oncology 14 (3), 249-256, 2013 | 758 | 2013 |
Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma CU Blank, EA Rozeman, LF Fanchi, K Sikorska, B van de Wiel, ... Nature medicine 24 (11), 1655-1661, 2018 | 744 | 2018 |
Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial L Voorwerk, M Slagter, HM Horlings, K Sikorska, KK van de Vijver, ... Nature medicine 25 (6), 920-928, 2019 | 724 | 2019 |
Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma D Liu, B Schilling, D Liu, A Sucker, E Livingstone, L Jerby-Arnon, ... Nature medicine 25 (12), 1916-1927, 2019 | 662 | 2019 |